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18 条记录 (耗时 0.008 秒)

    NUCLEOTIDE AND AMINO ACID SEQUENCES OF CANINE HERPESVIRUS gB, gC and gD AND USES THEREFOR
    5.
    发明公开
    NUCLEOTIDE AND AMINO ACID SEQUENCES OF CANINE HERPESVIRUS gB, gC and gD AND USES THEREFOR 失效
    HERPEVIREN GB，GC和GD DOG并且使用的核苷酸氨基酸序列

    公开(公告)号：EP0752888A4

    公开(公告)日：1997-05-21

    申请号：EP95915474

    申请日：1995-03-30

    申请人： VIROGENETICS CORP

    发明人： PAOLETTI ENZO ,  LIMBACH KEITH JEFFREY

    IPC分类号： C12N15/09 ,  A61K39/00 ,  A61K39/12 ,  A61K39/245 ,  A61P31/12 ,  A61P31/22 ,  C07H21/04 ,  C07K14/03 ,  C12N15/38 ,  C12P21/02 ,  A61K39/275 ,  A61K39/285 ,  C12N7/01

    CPC分类号： C07K14/005 ,  A61K39/00 ,  C12N2710/14143 ,  C12N2710/16722

    摘要： Disclosed and claimed are nucleotides for genes encoding the canine herpesvirus (CHV) gB, gC and gD homologues. These genes encode polypeptides of 879, 459 and 345 amino acids, respectively, which are also disclosed and claimed. The genes are useful as DNA probes or, for preparing PCR primers. The polypeptides are useful in antigenic, immunological or vaccine compositions. The nucleotides can be expressed in any suitable vector system, allowing for production of the polypeptides. Additionally, the vector system containing any or any combination of the nucleotides can be employed in an antigenic, immunological or vaccine composition, such as a poxvirus vector system, e.g., a CHV-vaccinia or avipox virus recombinant, as can the products from expression, i.e., the gB, gC and gD glycoproteins. Antibodies elicited by the glycoproteins or from expression of the vector containing the nucleotide (s) are also useful. Methods for making and using the composition are also disclosed and claimed. Also, specific canarypox-CHV gB, gC and gD recombinants vCP 320, vCP322 and vCP294 and methods for making and using them are also disclosed and claimed.

    MALARIA RECOMBINANT POXVIRUS VACCINE
    6.
    发明公开
    MALARIA RECOMBINANT POXVIRUS VACCINE 失效
    疟疾疫苗包含重组痘病毒

    公开(公告)号：EP0717636A4

    公开(公告)日：1997-05-21

    申请号：EP94919480

    申请日：1994-06-10

    申请人： VIROGENETICS CORP

    发明人： PAOLETTI ENZO ,  DE TAISNE CHARLES ,  TINE JOHN A

    IPC分类号： A61K38/00 ,  A61K39/00 ,  A61K39/015 ,  A61K39/275 ,  A61K39/285 ,  C07K14/445 ,  C12N7/01 ,  C12P21/02

    CPC分类号： C07K14/445 ,  A61K38/00 ,  A61K39/00

    摘要： What is described is a recombinant poxvirus, such as vaccinia or canarypox virus, containing foreign DNA from Plasmodium such as coding for at least one of CSP, PfSSP2, LSA-1, LSA-1-repeatless, MSA-1, SERA, AMA-1, Pfs25, MSA-1 N-terminal p83 and MSA-1 C-terminal gp42. What is also described is a vaccine containing the recombinant poxvirus for inducing an immunological response in a host animal inoculated with the vaccine. Preferred recombinants have attenuated virulence. In certain embodiments the vaccinia has deleted or disrupted the thymidine kinase gene, the hemorrhagic region, the A type inclusion body region, the host range gene region and, the large subunit, ribonucleotide reductase; and, contains coding sequences for CSP, PfSSP2, LSA-1-repeatless, MSA-1, SERA, AMA-1 and Pfs25. That embodiment is termed NYVAC-Pf7 and is a multicomponent, multistage vaccine since it codes for and expresses sporozoite proteins, liver stage proteins, blood stage proteins and, sexual stage proteins.