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公开(公告)号：EP4172173A1
公开(公告)日：2023-05-03
申请号：EP21833945.5
申请日：2021-06-27
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3.发明公开
公开(公告)号：EP4144762A1
公开(公告)日：2023-03-08
申请号：EP21797335.3
申请日：2021-04-27
申请人： Kaneka Corporation
摘要： A structure includes a water-insoluble fiber, and a low-molecular-weight antibody connected to the water-insoluble fiber. A method of producing a structure includes connecting a water-insoluble fiber and a low-molecular-weight antibody to each other.
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公开(公告)号：EP4031581A1
公开(公告)日：2022-07-27
申请号：EP20866701.4
申请日：2020-07-10
申请人： Apostle, Inc.
发明人： GE, Dongliang , WAN, Hao , ZHAO, Shuting , ZHANG, Bo , GUO, Xin
IPC分类号： C07K17/08 , C08F285/00 , G01N33/543
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5.发明公开
公开(公告)号：EP4025630A1
公开(公告)日：2022-07-13
申请号：EP20764392.5
申请日：2020-09-03
申请人： Université de Bordeaux , Institut Polytechnique de Bordeaux , Centre national de la recherche scientifique
IPC分类号： C08G83/00 , C08F283/06 , C07K17/08 , C08G69/10
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公开(公告)号：EP3599250A1
公开(公告)日：2020-01-29
申请号：EP18744269.4
申请日：2018-01-23
发明人： YU, Haoyang , WANG, Zhong , LI, Zhengcheng
IPC分类号： C07K17/08 , C07K16/46 , A61K39/44 , A61K47/59 , A61K47/60 , A61P35/00 , A61P37/02 , A61P29/00
摘要： The present invention relates to a multi-specific antibody conjugate (such as, a bispecific antibody conjugate), and a related composition, therapeutic method and use thereof. The antibody conjugate comprises a multispecific antibody, such as a bispecific antibody, conjugated to a nanomaterial. The antibody conjugate can be used to modulate an immune response, treat or prevent a disease or condition (e.g., a cancer, autoimmune disease, pathogen infection or inflammatory disease), etc..
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公开(公告)号：EP3572091A1
公开(公告)日：2019-11-27
申请号：EP19170008.7
申请日：2011-08-17
申请人： Ambrx, Inc.
发明人： KARYNOV, Vadim , KNUDSEN, Nick , HEWET, Amha , DE DIOS, Kristine , PINKSTAFF, Jason , SULLIVAN, Lorraine
IPC分类号： A61K38/22 , C07K14/64 , C07K17/08 , C07H21/04 , C07K1/04 , C12N1/19 , C12P21/02 , C12N1/21 , A61P9/00 , A61P9/10 , A61P31/00 , A61P17/02 , A61P25/28 , A61K47/60
摘要： Modified relaxin polypeptides and uses thereof are provided. In particular, modified relaxin polypeptide variants having substitutions with a non-naturally encoded amino acid in the A or B chain, especially residues 1, 5, 13, 18 and B chain residue 7. The non-natural amino acid is preferably a phenylalanine analog, especially para-acetyl-phenylalanine (pAcF or pAF). The relaxin variants are linked to compounds to improve their pharmacological properties, especially PEG having an average MW of between about 5 kDa and about 40 kDa , which is linked to the non-naturally encoded amino acid.
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公开(公告)号：EP2605789B1
公开(公告)日：2019-06-05
申请号：EP11818758.2
申请日：2011-08-17
申请人： Ambrx, Inc.
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公开(公告)号：EP2963055B1
公开(公告)日：2019-05-15
申请号：EP14757574.0
申请日：2014-02-26
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公开(公告)号：EP3287458A3
公开(公告)日：2018-04-11
申请号：EP17178305.3
申请日：2011-11-29
发明人： LIU, Jun O , WANG, Jingxin , GUO, Zufeng , LI, Wei , BHAT, Shridhar , DAS, Manisha
IPC分类号： C07D471/04 , C07D498/04 , C07D515/04 , C07D498/14 , A61K31/4353 , A61K31/436 , G01N33/566 , C07D515/14 , C07K17/08
CPC分类号： C07K7/645 , A61K31/4353 , A61K31/436 , C07D471/04 , C07D498/04 , C07D498/14 , C07D515/04 , C07D515/14 , C07K17/08 , G01N33/566
摘要： Provided are novel types of hybrid cyclic libraries of formula (I) that contain a known protein binding domain of a natural product. Also provided are synthetic methods to make such libraries and methods for the deconvolution of hits using partially split-pooled library compounds. Such methods are applicable for use with the entire human proteome to screen such libraries that bind and for the identification of hits.
摘要翻译： 提供了包含天然产物的已知蛋白质结合结构域的新型式（I）的杂合环状文库。 还提供了合成方法来制备这样的文库和用于使用部分分裂合并的文库化合物对命中进行解卷积的方法。 这样的方法适用于与整个人类蛋白质组一起使用来筛选结合这些文库并鉴定命中的文库。
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