摘要:
An ion trap such as an ion cyclotron resonance analyzer cell (trap) is described wherein the ion trap comprises a plurality of electrodes and comprising at least one integrated ion detector, preferably a position-sensitive and/or time-sensitive ion detector, wherein at least part of said ion detector is configured as an electrode of said ion trap. Methods of position-sensitive detection of ions in such ion trap are described as well.
摘要:
The presently disclosed subject matter provides methods for analyzing complex mixtures with ultra high resolution mass spectrometry. In particular, the presently disclosed subject matter provides methods for identifying and monitoring the presence of a compound within a complex mixture. In certain embodiments, the method includes providing a sample of the complex mixture; performing mass spectrometry on the sample of the complex mixture to obtain a mass spectrum; and identifying one or more peaks from the mass spectrum corresponding to the compound. In certain embodiments, the sample is obtained during production of the complex mixture, e.g., a pet food product. In certain embodiments, the sample is prepared by a single alcohol/water extraction step.
摘要:
A mass and velocity analyzer (48) has a cell (60) having four walls (62, 64, 66, 68) applied with time dependent RF potentials. The time dependent RF potentials create an RF field effectively rotating in the cell (60). The rotating RF field disperses an incident ion beam (46) accelerated into the cell (60) according to the mass-to-charge ratio and velocity distribution of ions (52) in the ion beam (46). The ions (52) of the ion beam (46) either collide with an ion detector (54) or deflect away from the ion detector (54), depending on the mass-to-charge ratio, RF amplitude and RF frequency.
摘要:
A method for improving the calibration of a Fourier transform ion cyclotron resonance mass spectrometer wherein the frequency spectrum of a sample has been measured and the frequency ( f ) and intensity ( I ) of at least three species having known mass to charge ( m / z ) ratios and one specie having an unknown ( m / z ) ratio have been identified. The method uses the known ( m / z ) ratios, frequencies, and intensities at least three species to calculate coefficients A, B, and C, wherein the mass to charge ratio of a least one of the three species ( m / z ) i is equal to A f i + B f i 2 + C · G ( I i ) f i Q wherein f i is the detected frequency of the specie, G( I i ) is a predetermined function of the intensity of the specie, and Q is a predetermined exponent. Using the calculated values for A, B, and C, the mass to charge ratio of the unknown specie ( m /z) ii is calculated as the sum of A f ii + B f ii 2 + C·G ( I ii ) f ii Q wherein f ii is the measured frequency of the unknown specie, and ( I ii ) is the measured intensity of the unknown specie.