公开(公告)号：JP2009257850A

公开(公告)日：2009-11-05

申请号：JP2008105229

申请日：2008-04-15

Applicant: Hitachi High-Technologies Corp ,  株式会社日立ハイテクノロジーズ

Inventor： YOKOSUKA TOSHIYUKI ,  YOSHINARI KIYOMI ,  KOBAYASHI KINYA

IPC: G01N27/62

Abstract: PROBLEM TO BE SOLVED: To provide a mass analyzing system capable of determining having high valence number is detected because the peak interval (1/valence number) of an isotope peak becomes narrow in the ion having the high valence number and it is difficult to determine the valence number in the present mass analyzing system.
SOLUTION: The mass analyzing system is characterized in that a plurality of the ion kinds of the same compounds having the same mass and different valence numbers are predetermined from a mass analyzing spectrum, the least common multiple is calculated within the range of tolerance predetermined with respect to the M/Z value of a plurality of the ion kinds, and the masses of a plurality of the compounds and the valence numbers of the respective ion kinds are estimated. As a result, the enhancement of data analyzing precision after the completion of analysis and the reduction of the load of a tester are expected. Further, by using a tandem mass analyzing method, the measurement of a sample containing a plurality of components in a mixed state or the avoidance of dublicate analysis to the same component different in valence number becomes possible.
COPYRIGHT: (C)2010,JPO&INPIT

Abstract translation: 要解决的问题：为了提供能够确定具有高价数的质量分析系统，因为同位素峰的峰值间隔（1 /价数）在具有高价数的离子中变窄，并且是 难以确定当前质量分析系统中的价数。 解决方案：质量分析系统的特征在于，从质量分析光谱预先确定具有相同质量和不同价数的相同化合物的多个离子种类，在公差范围内计算最小公倍数 相对于多个离子种类的M / Z值预先确定，并且估计多种化合物的质量和各种离子种类的价数。 因此，预期完成分析后的数据分析精度的提高和测试仪的负载的减少。 此外，通过使用串联质量分析方法，可以将含有混合状态的多个成分的样品的测量或者避免对价数不同的相同成分进行公开分析。 版权所有（C）2010，JPO＆INPIT

公开(公告)号：JP2008224636A

公开(公告)日：2008-09-25

申请号：JP2007067798

申请日：2007-03-16

Applicant: Hitachi High-Technologies Corp ,  株式会社日立ハイテクノロジーズ

Inventor： YOSHINARI KIYOMI ,  YOKOSUKA TOSHIYUKI ,  KOBAYASHI KINYA ,  HIRABAYASHI TSUDOI

IPC: G01N27/62

Abstract: PROBLEM TO BE SOLVED: To provide a system that executes the search of variation protein and metabolite, and the like, (marker) specific to an ill patient using MS, with high accuracy and high-throughput.
SOLUTION: The mass spectrometry system analyzes data, which has just been acquired, in real time, and compares the results of the data a plurality of samples, which has already been acquired and has previously statistically treated, in real time; and thereby, when it is determined that there is a possibility of variance component being present, next analysis content is optimized.
COPYRIGHT: (C)2008,JPO&INPIT

Abstract translation: 要解决的问题：以高精度和高通量提供使用MS对病人特异性的（变异蛋白质和代谢物）等的检索（标记）的检测系统。 解决方案：质谱系统实时分析刚刚获得的数据，并将已经获得并已经进行了统计处理的多个样本的数据实时比较; 因此，当确定存在方差分量的可能性时，优化下一个分析内容。 版权所有（C）2008，JPO＆INPIT

公开(公告)号：JP2008170346A

公开(公告)日：2008-07-24

申请号：JP2007004975

申请日：2007-01-12

Applicant: Hitachi High-Technologies Corp ,  株式会社日立ハイテクノロジーズ

Inventor： KOBAYASHI KINYA ,  YOKOSUKA TOSHIYUKI ,  YOSHINARI KIYOMI

IPC: G01N27/62

Abstract: PROBLEM TO BE SOLVED: To provide a mass analysis system, capable of analyzing trace amounts of components contained in a sample, without having to remeasure and extend the analysis time for ions per analysis case.
SOLUTION: In the tandem-type mass analyzing system, a database is searched, when the candidate of parent ions for MS
2 mass analysis is selected from among the peak ions of an MS
1 mass spectrum and the components that are not stored in the database or the component that are stored in the database but not identified in the arrangement of molecules with a predetermined number N or larger is selected as parent ions, and MS
2 mass analysis is performed, until a predetermined number N or larger of the rows of molecules are identified, with respect to the selected parent ions.
COPYRIGHT: (C)2008,JPO&INPIT

Abstract translation: 要解决的问题：提供能够分析样品中包含的痕量成分的质量分析系统，而不必对每个分析情况的离子进行重新测量和延长分析时间。 解决方案：在串联型质量分析系统中，当从MS 2的峰离子中选择用于MS 2 质量分析的亲本离子的候选物时，搜索数据库。 1质谱，并且选择未存储在数据库中的组分或存储在数据库中但未在具有预定数目N或更大数量N的分子排列中识别的组分的组分作为母体离子， 进行SP> 2 质量分析，直到相对于所选择的母体离子识别预定数量N或更大的分子行。 版权所有（C）2008，JPO＆INPIT

公开(公告)号：JP2008008801A

公开(公告)日：2008-01-17

申请号：JP2006180625

申请日：2006-06-30

Applicant: Hitachi High-Technologies Corp ,  株式会社日立ハイテクノロジーズ

Inventor： YOSHINARI KIYOMI ,  KOBAYASHI KINYA ,  YOKOSUKA TOSHIYUKI ,  HIRABAYASHI TSUDOI ,  TERUI YASUSHI

IPC: G01N27/62 ,  H01J49/26

Abstract: PROBLEM TO BE SOLVED: To provide a mass analyzing system becoming possible to optimize an analyzing condition in the analyzing time of the structure of a substance serving as a measuring target and capable of acquiring analyzing data with less failure in a large data quantity.
SOLUTION: Just acquired data are analyzed in a real time to evaluate whether an analyzing condition is optimum depending on whether the acquired data quantity satisfies a prescribed value. In the case where the data quantity of mass spectrum data does not satisfy the prescribed value, the analyzing condition is optimized in a real time on the basis of an analyzing condition adjusting database.
COPYRIGHT: (C)2008,JPO&INPIT

Abstract translation: 要解决的问题：提供一种质量分析系统，可以在用作测量目标的物质的结构的分析时间内优化分析条件，并且能够以较大的数据量获取具有较少故障的分析数据 。 解决方案：实时分析刚刚获取的数据，以根据获取的数据量是否满足规定值来评估分析条件是否是最佳的。 在质谱数据的数据量不满足规定值的情况下，基于分析条件调整数据库，实时地优化分析条件。 版权所有（C）2008，JPO＆INPIT

公开(公告)号：JP2007256126A

公开(公告)日：2007-10-04

申请号：JP2006081899

申请日：2006-03-24

Applicant: Hitachi High-Technologies Corp ,  株式会社日立ハイテクノロジーズ

Inventor： KOBAYASHI KINYA ,  YOSHINARI KIYOMI ,  YOKOSUKA TOSHIYUKI ,  HIRABAYASHI TSUDOI

IPC: G01N27/62

CPC classification number: H01J49/02 ,  H01J49/0027

Abstract: PROBLEM TO BE SOLVED: To analyze a peptide ion derived from a protein different in total ion amount while already measured, as a tandem mass spectrometric target, and to quantitatively evaluate the peptide ion derived from the micro amount of protein difficult to be analyzed until now, when the protein or a peptide is analyzed by tandem mass spectrometry, or when a variable component between different kinds of samples is evaluated quantitatively. SOLUTION: In this system of the present invention, a derived peptide data measured in the first time is stored in an internal database, to be collated precisely with a measured data in the second time, a process for selecting an already measured peptide peak fluctuated in a relative amount, as the next tandem analysis target, is executed in a real time during the measurement, and the peptide not fluctuated in the relative amount is thereby avoided from being analyzed, so as to solve the problem hereinbefore. COPYRIGHT: (C)2008,JPO&INPIT

Abstract translation: 要解决的问题：为了分析来自于已经测量的总离子量不同的蛋白质的肽离子，作为串联质谱目标，并定量评价从微量的蛋白质衍生的肽离子难以 当通过串联质谱法分析蛋白质或肽时，或当定量评价不同种类的样品之间的可变成分时，分析。 解决方案：在本发明的该系统中，将第一次测定的衍生肽数据存储在内部数据库中，与第二次的测定数据精确对照，选择已经测定的肽的方法 由于下一个串联分析目标在测量期间以实时的方式执行，峰值波动相对量，从而避免肽不相对量的波动被分析，从而解决了上述问题。 版权所有（C）2008，JPO＆INPIT

公开(公告)号：JP2007046966A

公开(公告)日：2007-02-22

申请号：JP2005230234

申请日：2005-08-09

Applicant: Hitachi High-Technologies Corp ,  株式会社日立ハイテクノロジーズ

Inventor： HIRABAYASHI TSUDOI ,  KOBAYASHI KINYA ,  HASHIMOTO YUICHIRO ,  YOKOSUKA TOSHIYUKI ,  YOSHINARI KIYOMI

IPC: G01N27/62 ,  H01J49/42

Abstract: PROBLEM TO BE SOLVED: To solve the problem, where tandem mass spectra of all of components are difficult to obtain efficiently when a sample containing extremely many components or chemical noise is analyzed.
SOLUTION: A mass analyzing system having an internal database which is registered with the mass data [mass (m) and charge number (z)] of ions to be analyzed, an LC holding time and the tandem mass analyzing spectrum data (m/z or intensity of dissociated ions) is used. After the mass analyzing spectra are acquired, the internal database is searched and the precursor ion group is classified into some groups corresponding to the number of precursor ion candidates or the like in tandem mass analysis. An analyzing sequence for collectively executing the tandem mass analysis at every group is determined in a real time to analyze mass.
COPYRIGHT: (C)2007,JPO&INPIT

Abstract translation: 要解决的问题：为了解决当分析含有非常多的组分或化学噪声的样品时，所有组分的串联质谱难以有效获得的问题。 解决方案：具有与要分析的离子的质量数据[质量（m）和电荷数（z）]对应的内部数据库的质量分析系统，LC保持时间和串联质量分析光谱数据 m / z或解离离子的强度）。 在获得质谱分析光谱后，搜索内部数据库，并将前体离子组分类为与串联质量分析中的前体离子候选物数量相对应的一些基团。 确定在每个组中共同执行串联质量分析的分析顺序，以实时分析质量。 版权所有（C）2007，JPO＆INPIT

公开(公告)号：JP2004191077A

公开(公告)日：2004-07-08

申请号：JP2002356120

申请日：2002-12-09

Applicant: Hitachi High-Technologies Corp ,  Hitachi Ltd ,  株式会社日立ハイテクノロジーズ ,  株式会社日立製作所

Inventor： KOBAYASHI KINYA ,  YOSHINARI KIYOMI ,  OTAKE ATSUSHI

IPC: G01N27/62 ,  G01N33/483 ,  G01N33/68 ,  H01J49/04 ,  H01J49/40 ,  H01J49/42

CPC classification number: H01J49/0036

Abstract: PROBLEM TO BE SOLVED: To provide a compound structure analysis system capable of coping with an unknown structure material, identifying a parent ion highly accurately, and estimating the structure of the parent ion. SOLUTION: Molecular orbital analysis and molecular mechanic calculation are performed in addition to collision energy calculation of the parent ion and a dissociated ion in an MS device to the parent ion structure assumed from mass spectrometric data relative to MS n , to thereby derive highly accurately the structures of the parent ion and the dissociated ion and to display it. Since the structures of the parent ion and the dissociated ion can be evaluated from thermal, chemical or energetic characteristics by the means, the parent ion structure can be derived and evaluated with extremely high accuracy from the mass spectrometric data. COPYRIGHT: (C)2004,JPO&NCIPI

Abstract translation: 要解决的问题：提供能够应对未知结构材料的复合结构分析系统，高精度地鉴定母离子并估计母离子的结构。 解决方案：分子轨道分析和分子力学计算除了母体离子的碰撞能量计算和MS器件中的离解离子与从质谱数据相对于MS n < / SP>，从而高精度地得到母体离子和离解离子的结构并显示出来。 由于母体离子和离解离子的结构可以通过手段从热，化学或能量特性得到评估，因此可以从质谱数据中以极高的精度得出和评估母体离子结构。 版权所有（C）2004，JPO＆NCIPI