公开(公告)号：JPH05117221A

公开(公告)日：1993-05-14

申请号：JP8235792

申请日：1992-04-03

申请人： SHIYUTAALE HORANTO BV

发明人： RAURENCHIUSU KORUNERISU YOSEFU ,  YOANNA ANTONIA MARIA FUAN DEN

IPC分类号： C07D203/06 ,  C07C267/00 ,  C07C271/06 ,  C07D277/04 ,  C07F7/10 ,  C08G18/02 ,  C08G18/28 ,  C08G18/79 ,  C08J3/24 ,  C08K5/00 ,  C08K5/29 ,  C08L33/00 ,  C08L33/04 ,  C08L75/00 ,  C08L75/04 ,  C09D133/00 ,  C09D133/04

公开(公告)号：JPS63258415A

公开(公告)日：1988-10-25

申请号：JP8396287

申请日：1987-04-07

申请人： BOEHRINGER MANNHEIM GMBH

发明人： ERUMAARU BOJIIZU ,  HERUBERUTO BERUGAA ,  BUORUFUGANGU KANPE ,  UBUE BITSUKERU ,  ARUFURETSUDO GURAAFUE

IPC分类号： C07D203/08 ,  A61K31/395 ,  A61K31/396 ,  A61K31/40 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61P37/04 ,  C07D203/06 ,  C07D401/04 ,  C07D403/06 ,  C07D405/04 ,  C07D409/04

摘要： A 2-cyanaziridine derivative of the formula wherein R' is a straight-chained or branched, saturated or mono- or polyunsaturated aliphatic hydrocarbon radical with up to 8 carbon atoms, which is substituted by an aromatic nitrogen-containing heterocyclic radical with 5 or 6 ring-members and 1, 2 or 3 nitrogen atoms optionally substituted by halogen, alkoxy with up to 8 carbon atoms, alkyl with up to 8 carbon atoms, hydroxyl, carbalkoxy with up to 9 carbon atoms, carbamoyl, dialkylamino the alkyl moieties of which having up to 8 carbon atoms, cycloalkylamino, the cycloalkyl moiety having 3-10 carbon atoms, acetylamino, nitro, cyano, acetyl, alkylthio with up to 8 carbon atoms, alkylsulphinyl with up to 8 carbon atoms, alkylsulphonyl with up to 8 carbon atoms, sulphamoyl, phenyl, trifluoromethyl, phenoxy, acetoxy or methylenedioxy; or a pharmacologically acceptable salt thereof, exhibits immune stimulating activity.

公开(公告)号：JPS5522694A

公开(公告)日：1980-02-18

申请号：JP9878079

申请日：1979-08-03

申请人： BOEHRINGER MANNHEIM GMBH

发明人： ERUMAARU BOJIIZU ,  HERUBERUTO BERUGAA ,  BUORUFUGANGU KANPE ,  UBUE BITSUKERU ,  ARUFURETSUDO GURAAFUE

IPC分类号： C07D203/08 ,  A61K31/395 ,  A61K31/396 ,  A61K31/40 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61P37/04 ,  C07D203/06 ,  C07D401/04 ,  C07D403/06 ,  C07D405/04 ,  C07D409/04

摘要： A 2-cyanaziridine derivative of the formula wherein R' is a straight-chained or branched, saturated or mono- or polyunsaturated aliphatic hydrocarbon radical with up to 8 carbon atoms, which is substituted by an aromatic nitrogen-containing heterocyclic radical with 5 or 6 ring-members and 1, 2 or 3 nitrogen atoms optionally substituted by halogen, alkoxy with up to 8 carbon atoms, alkyl with up to 8 carbon atoms, hydroxyl, carbalkoxy with up to 9 carbon atoms, carbamoyl, dialkylamino the alkyl moieties of which having up to 8 carbon atoms, cycloalkylamino, the cycloalkyl moiety having 3-10 carbon atoms, acetylamino, nitro, cyano, acetyl, alkylthio with up to 8 carbon atoms, alkylsulphinyl with up to 8 carbon atoms, alkylsulphonyl with up to 8 carbon atoms, sulphamoyl, phenyl, trifluoromethyl, phenoxy, acetoxy or methylenedioxy; or a pharmacologically acceptable salt thereof, exhibits immune stimulating activity.