公开(公告)号：JP2003516384A

公开(公告)日：2003-05-13

申请号：JP2001543502

申请日：2000-12-04

IPC分类号： C07D249/08 ,  A01N47/12 ,  A01N47/20 ,  C07C271/28 ,  C07D207/325 ,  C07D211/74 ,  C07D213/53 ,  C07D213/61 ,  C07D213/63 ,  C07D213/64 ,  C07D213/65 ,  C07D231/12 ,  C07D231/14 ,  C07D231/16 ,  C07D233/61 ,  C07D233/64 ,  C07D233/68 ,  C07D233/90 ,  C07D239/26 ,  C07D239/30 ,  C07D239/34 ,  C07D261/08 ,  C07D261/10 ,  C07D263/10 ,  C07D263/32 ,  C07D263/34 ,  C07D265/08 ,  C07D271/06 ,  C07D271/10 ,  C07D275/02 ,  C07D277/20 ,  C07D277/28 ,  C07D277/32 ,  C07D277/36 ,  C07D277/56 ,  C07D279/06 ,  C07D295/12 ,  C07D307/52 ,  C07D307/56 ,  C07D307/68 ,  C07D333/20 ,  C07D333/28 ,  C07D333/38

公开(公告)号：JP2003064059A

公开(公告)日：2003-03-05

申请号：JP2002172494

申请日：2002-06-13

申请人： Nippon Soda Co Ltd ,  日本曹達株式会社

发明人： MIYAHARA OSAMU ,  SATO JUNJI ,  FURUGUCHI MASAMI ,  KATO KAZUNARI

IPC分类号： C07D239/28 ,  A01N43/54 ,  C07D239/30 ,  C07D239/34

摘要： PROBLEM TO BE SOLVED: To provide a new pyrimidine compound and its salt capable of providing an active ingredient of a safely usable herbicide having sure effects, a method for producing the same and the herbicide comprising the pyrimidine compound or its salt as the active ingredient.
SOLUTION: This pyrimidine compound is represented by the general formula (1) (wherein, R1 denotes a 1-6C alkyl group, a 3-6C cycloalkyl group, a 1-6C haloalkyl group or the like; R2 and R3 denote each independently a 1-6C alkyl group, a 3-6C cycloalkyl group or a 1-6C haloalkyl group; R4 denotes hydrogen atom, a 1-4C alkyl group or the like; X denotes a halogen atom, a 1-4C alkyl group, a 1-3C haloalkyl group or the like; and n denotes 0 or an integer of 1-5). The method for producing the same is provided and the herbicide comprises the compound or its salt.
COPYRIGHT: (C)2003,JPO

摘要翻译： 要解决的问题：提供能够提供具有确定作用的可安全使用的除草剂的活性成分的新的嘧啶化合物及其盐，其制备方法和包含嘧啶化合物或其盐作为活性成分的除草剂。 解决方案：该嘧啶化合物由通式（1）表示（其中，R1表示1-6C烷基，3-6C环烷基，1-6C卤代烷基等; R2和R3各自独立地表示 1-6C烷基，3-6C环烷基或1-6C卤代烷基; R4表示氢原子，1-4C烷基等; X表示卤素原子，1-4C烷基，1 -3C卤代烷基等; n表示0或1-5的整数）。 提供了其制备方法，除草剂包括化合物或其盐。

公开(公告)号：JP2002205986A

公开(公告)日：2002-07-23

申请号：JP2001339893

申请日：2001-11-05

申请人： TAKEDA CHEMICAL INDUSTRIES LTD

发明人： KURAGANO TAKASHI ,  TANAKA YASUSHI

IPC分类号： A01N43/54 ,  A01N43/653 ,  A01N43/84 ,  A01N47/04 ,  A01N47/20 ,  C07D239/26 ,  C07D239/30 ,  C07D239/34 ,  C07D239/38 ,  C07D239/42 ,  C07D405/04 ,  C07D413/04 ,  C07D521/00

摘要： PROBLEM TO BE SOLVED: To obtain a pyrimidine derivative having excellent selectively herbicidal activity. SOLUTION: The pyrimidine derivative is shown by the formula [wherein, R1p and R1q are each H, a halogen atom, a (substituted) 1-6C alkyl, a 1-6C alkoxy, or the like, and may be the same as each other; R2 is a halogen atom, a 1-6C alkyl, cyano, or the like; and Ar is a (substituted) phenyl or a (substituted) condensed heterocyclic ring]. The herbicide comprises the above pyrimidine derivative.

公开(公告)号：JP2001261648A

公开(公告)日：2001-09-26

申请号：JP2000071574

申请日：2000-03-15

申请人： NIPPON SODA CO

发明人： KUMITA IZUMI ,  NODA KAORU

IPC分类号： C07D239/26 ,  A61K31/426 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4409 ,  A61K31/4418 ,  A61K31/495 ,  A61K31/535 ,  A61P31/10 ,  C07D213/26 ,  C07D213/61 ,  C07D213/68 ,  C07D213/70 ,  C07D213/71 ,  C07D213/84 ,  C07D239/28 ,  C07D239/30 ,  C07D239/38 ,  C07D265/08 ,  C07D277/22 ,  C07D277/24

摘要： PROBLEM TO BE SOLVED: To obtain an antifungal agent and an antimicrobial agent for agriculture and horticulture having a squalene epoxidase-inhibiting activity. SOLUTION: The nitrogen-containing heterocyclic compounds are expressed by general formulas (1), (2) and (3), wherein R1 and R2 express each a halogen; R3 expresses a halogen, a 1-6C alkoxy or the like; n is 0, 1-3; B expresses CH or N; Y expresses H, a 1-6C alkoxy or the like; R4 expresses a phenyl or naphthyl which may be substituted.

公开(公告)号：JP3170900B2

公开(公告)日：2001-05-28

申请号：JP28273892

申请日：1992-10-21

IPC分类号： C07D239/30 ,  C07D239/34

公开(公告)号：JP3170077B2

公开(公告)日：2001-05-28

申请号：JP34277492

申请日：1992-12-22

IPC分类号： A61K31/35 ,  A23K1/16 ,  A61K31/365 ,  A61K31/425 ,  A61K31/426 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4412 ,  A61K31/495 ,  A61K31/50 ,  A61K31/505 ,  A61K31/53 ,  A61K31/54 ,  A61K45/06 ,  A61P33/00 ,  A61P33/14 ,  C07D213/61 ,  C07D213/63 ,  C07D213/64 ,  C07D213/69 ,  C07D213/70 ,  C07D237/12 ,  C07D237/14 ,  C07D237/16 ,  C07D237/18 ,  C07D239/30 ,  C07D239/34 ,  C07D239/38 ,  C07D239/52 ,  C07D239/56 ,  C07D239/58 ,  C07D241/16 ,  C07D241/18 ,  C07D251/16 ,  C07D251/18 ,  C07D251/22 ,  C07D251/34 ,  C07D251/38 ,  C07D251/46 ,  C07D251/52 ,  C07D277/12 ,  C07D277/14 ,  C07D277/16 ,  C07D277/20 ,  C07D277/32 ,  C07D277/34 ,  C07D277/36 ,  C07D277/58 ,  C07D279/06

公开(公告)号：JP2000186067A

公开(公告)日：2000-07-04

申请号：JP35121899

申请日：1999-12-10

申请人： BASF AG

发明人： BAYER HERBERT ,  SAUTER HUBERT ,  MUELLER RUTH ,  GRAMMENOS WASSILIOS ,  HARREUS ALBRECHT ,  KIRSTGEN REINHARD ,  ROEHL FRANZ ,  AMMERMANN EBERHARD ,  LORENZ GISELA

IPC分类号： C07D249/08 ,  A01N20060101 ,  A01N37/00 ,  A01N37/36 ,  A01N37/44 ,  A01N37/50 ,  A01N41/10 ,  A01N43/00 ,  A01N43/08 ,  A01N43/10 ,  A01N43/12 ,  A01N43/36 ,  A01N43/40 ,  A01N43/42 ,  A01N43/50 ,  A01N43/54 ,  A01N43/56 ,  A01N43/58 ,  A01N43/60 ,  A01N43/66 ,  A01N43/707 ,  A01N43/72 ,  A01N43/76 ,  A01N43/78 ,  A01N43/80 ,  A01N43/824 ,  A01N43/836 ,  A01N43/88 ,  A01N47/02 ,  A01P3/00 ,  A01P7/04 ,  C07C20060101 ,  C07C205/04 ,  C07C249/08 ,  C07C251/34 ,  C07C251/36 ,  C07C251/38 ,  C07C251/48 ,  C07C251/50 ,  C07C251/52 ,  C07C251/54 ,  C07C251/56 ,  C07C251/60 ,  C07C255/07 ,  C07C255/12 ,  C07C255/62 ,  C07C255/64 ,  C07C259/06 ,  C07C259/14 ,  C07C309/04 ,  C07C309/28 ,  C07C317/18 ,  C07C317/22 ,  C07C317/26 ,  C07C317/44 ,  C07C323/12 ,  C07C323/19 ,  C07C323/23 ,  C07C325/00 ,  C07C327/38 ,  C07C327/42 ,  C07C327/48 ,  C07C327/58 ,  C07D207/32 ,  C07D207/323 ,  C07D207/333 ,  C07D207/36 ,  C07D211/72 ,  C07D211/88 ,  C07D213/30 ,  C07D213/50 ,  C07D213/53 ,  C07D213/61 ,  C07D213/64 ,  C07D213/65 ,  C07D213/68 ,  C07D213/71 ,  C07D213/79 ,  C07D213/80 ,  C07D215/20 ,  C07D215/22 ,  C07D231/12 ,  C07D231/20 ,  C07D231/22 ,  C07D233/61 ,  C07D233/64 ,  C07D237/08 ,  C07D237/12 ,  C07D237/14 ,  C07D239/26 ,  C07D239/28 ,  C07D239/30 ,  C07D239/34 ,  C07D239/36 ,  C07D239/38 ,  C07D239/74 ,  C07D241/12 ,  C07D241/16 ,  C07D241/18 ,  C07D241/44 ,  C07D251/16 ,  C07D251/26 ,  C07D251/30 ,  C07D261/06 ,  C07D261/08 ,  C07D261/10 ,  C07D261/12 ,  C07D263/32 ,  C07D263/34 ,  C07D263/46 ,  C07D271/06 ,  C07D271/10 ,  C07D275/02 ,  C07D277/20 ,  C07D277/24 ,  C07D277/28 ,  C07D277/32 ,  C07D277/34 ,  C07D277/36 ,  C07D285/08 ,  C07D285/12 ,  C07D307/12 ,  C07D307/36 ,  C07D307/42 ,  C07D307/52 ,  C07D307/56 ,  C07D307/58 ,  C07D333/16 ,  C07D333/22 ,  C07D333/28 ,  C07D333/32 ,  C07D285/01

摘要： PROBLEM TO BE SOLVED: To obtain the subject new compounds useful as intermediate compounds for the production of phenylacetic acid derivatives suitable as bactericides, effective for a wide variety of phytopathogens and usable also as leaf and soil disinfectants. SOLUTION: The objective compound is expressed by the formula R5ON=C (R4)-C(R3)=NOH [R3 is H, cyano, nitro, hydroxy, amino, a halogen, a 1-4C (halo)alkyl or the like; R4 is H, cyano, nitro, hydroxy, amino, a halogen, a 1-6C alkyl or the like; R5 is H, a 1-10C alkyl or the like], e.g. (E,E)-2- methoxyimino-2-[2'-(1"-methyl,1"-acetyl)-iminoxymethyl]phenylacetic acid methyl ester. The objective compound of the formula can be produced by reacting the corresponding hydroxyimine of the formula HON=C(R4)-C(R3)=NOH with a nucleophilically substituted reagent of the formula R5-L2 (L2 is a nucleophilic exchangeable eliminable group such as a halogen or sulfonate).

公开(公告)号：JP3046896B2

公开(公告)日：2000-05-29

申请号：JP18220293

申请日：1993-06-29

IPC分类号： C07D239/30 ,  C07D239/54

公开(公告)号：JP2000136191A

公开(公告)日：2000-05-16

申请号：JP28523599

申请日：1999-10-06

申请人： WAKUNAGA PHARMA CO LTD

发明人： YAZAKI AKIRA ,  SHINNO RYOKO ,  OSHITA YOSHIHIRO ,  HIRAO YUZO ,  AMANO HIROTAKA ,  HAYASHI NORIHIRO ,  KURAMOTO YASUHIRO

IPC分类号： C07D213/74 ,  A61K31/00 ,  A61K31/435 ,  A61K31/4375 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/444 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/495 ,  A61K31/496 ,  A61K31/505 ,  A61K31/506 ,  A61P31/00 ,  A61P31/04 ,  C07D205/04 ,  C07D213/61 ,  C07D213/72 ,  C07D213/73 ,  C07D213/75 ,  C07D213/80 ,  C07D213/85 ,  C07D215/06 ,  C07D239/30 ,  C07D239/42 ,  C07D239/46 ,  C07D239/48 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D471/04 ,  C07K5/062

摘要： PROBLEM TO BE SOLVED: To provide a new pyridonecarboxylic acid derivative or its salt showing excellent antibacterial action and oral absorption, and also to provide an antibacterial agent including the same. SOLUTION: This new pyridonecarboxylic acid derivative is 1-(6-amino-3,5- difluoropyridin-2-yl)-8-chloro-6-fluoro-7-(3-hydroxyazetidin-1-yl)-4-o xo-1,4- dihydroquinoline-3-carboxylic acid or its salt. This antibacterial agent includes the same substance as an active principle.

公开(公告)号：JPH11343285A

公开(公告)日：1999-12-14

申请号：JP5210799

申请日：1999-03-01

申请人： HOECHST AG

发明人： BARTLETT ROBERT R ,  KAEMMERER FRIEDRICH-JOHANNES

IPC分类号： C07C233/58 ,  A61K31/00 ,  A61K31/16 ,  A61K31/165 ,  A61K31/166 ,  A61K31/275 ,  A61K31/36 ,  A61K31/395 ,  A61K31/415 ,  A61K31/416 ,  A61K31/4184 ,  A61K31/42 ,  A61K31/422 ,  A61K31/425 ,  A61K31/426 ,  A61K31/428 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4418 ,  A61K31/4427 ,  A61K31/4439 ,  A61K31/496 ,  A61K31/505 ,  A61K31/506 ,  A61P35/00 ,  A61P35/02 ,  C07C237/16 ,  C07C255/21 ,  C07C255/23 ,  C07C255/41 ,  C07C317/40 ,  C07D211/16 ,  C07D211/40 ,  C07D213/00 ,  C07D213/75 ,  C07D231/56 ,  C07D235/30 ,  C07D235/32 ,  C07D239/30 ,  C07D239/42 ,  C07D261/08 ,  C07D261/18 ,  C07D277/20 ,  C07D277/30 ,  C07D277/38 ,  C07D277/46 ,  C07D277/68 ,  C07D277/82 ,  C07D295/16 ,  C07D317/66 ,  C07D413/12

摘要： PROBLEM TO BE SOLVED: To obtain a new compound capable of preventing proliferation of tumor cells without damaging protection system of a body, and useful for treatment of leukemia such as T- AND B-cell type chronic leukemia, lymph node cancer such as Hodgkin's type and non Hodgkin's type lymphoma, or the like. SOLUTION: This new compound is a compound of formula I (R is H, a 2-6C alkyl or the like; R is H, a 2-3C alkenyl or the like; R is pyridyl substituted with a halogen or the like, a group of formula II or the like; R to R are each a halogen, nitro or the like), e.g. 5-methylisoxazole-4-carbox(4- trifluoromethyl)anilide. The compound of formula I is obtained, for example, by reacting a compound of formula III (X is a halogen), (e.g. 5-methylisoxazole-4- carbonyl chloride) with an amine of formula IV (e.g. 4-trifluoromethylaniline). The daily dose for treatment of an adult patient suffered from leukemia and having 70 kg weight is preferably about 25-100 mg when being orally administered.