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    Microorganisms for the production of methacrylic acid
    56.
    发明专利
    Microorganisms for the production of methacrylic acid 审中-公开
    用于生产甲基丙烯酸的微生物

    公开(公告)号：JP2014147400A

    公开(公告)日：2014-08-21

    申请号：JP2014108853

    申请日：2014-05-27

    申请人： Genomatica Inc ,  ジェノマティカ, インコーポレイテッド

    发明人： BURK MARK J ,  ANTHONY P BURGARD ,  ROBIN E OSTERHOUT ,  PRITI PHARKYA

    IPC分类号： C12N1/21 ,  C12N1/15 ,  C12N1/19 ,  C12N15/09 ,  C12P7/40

    CPC分类号： C12P7/42 ,  C12N9/0008 ,  C12N9/1096 ,  C12N9/88 ,  C12N9/90 ,  C12P7/40 ,  C12Y102/01 ,  C12Y206/01022 ,  C12Y403/01 ,  C12Y504/99002

    摘要： PROBLEM TO BE SOLVED: To provide microorganisms for the production of methacrylic acid.SOLUTION: The invention provides a non-naturally occurring microbial organism having a 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid pathway. The microbial organism contains at least one exogenous nucleic acid encoding enzymes in the 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid pathway. The invention additionally provides a method for producing 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid. The method can include culturing a 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid producing microbial organism expressing at least one exogenous nucleic acid encoding 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid pathway enzymes in a sufficient amount and culturing under conditions to produce 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid for a sufficient period of time.

    摘要翻译： 要解决的问题：提供用于生产甲基丙烯酸的微生物。解决方案：本发明提供了具有2-羟基异丁酸，3-羟基异丁酸或甲基丙烯酸途径的非天然存在的微生物。 微生物生物体含有2-羟基异丁酸，3-羟基异丁酸或甲基丙烯酸途径中至少一种编码酶的外源核酸。 本发明还提供了2-羟基异丁酸，3-羟基异丁酸或甲基丙烯酸的制备方法。 该方法可以包括培养足够量的表达至少一种编码2-羟基异丁酸，3-羟基异丁酸或甲基丙烯酸途径酶的外源核酸的2-羟基异丁酸，3-羟基异丁酸或产生甲基丙烯酸的微生物，并在 产生2-羟基异丁酸，3-羟基异丁酸或甲基丙烯酸足够的时间的条件。

    Primary alcohol producing organism
    57.
    发明专利
    Primary alcohol producing organism 审中-公开
    一级酒精生产有机体

    公开(公告)号：JP2014100147A

    公开(公告)日：2014-06-05

    申请号：JP2014042892

    申请日：2014-03-05

    申请人： Genomatica Inc ,  ジェノマティカ, インコーポレイテッド

    发明人： SUN JUN ,  PRITI PHARKYA ,  ANTHONY P BURGARD

    IPC分类号： C12N1/19 ,  C12N1/15 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12P7/04 ,  C12P7/64

    CPC分类号： C12P7/04 ,  C12N9/0006 ,  C12N9/0008 ,  C12N9/001 ,  C12N9/1029 ,  C12N9/88 ,  C12N15/52 ,  C12P7/02 ,  C12Y101/01001 ,  C12Y101/01035 ,  C12Y102/0105 ,  C12Y203/01009 ,  C12Y203/01016 ,  C12Y402/01017

    摘要： PROBLEM TO BE SOLVED: To provide primary alcohol producing organisms.SOLUTION: This invention provides a non-naturally occurring microbial organism having at least one exogenous gene insertion and/or one or more gene disruptions that confer production of primary alcohols. A method for producing a primary alcohol includes culturing a non-naturally occurring microbial organism. In some aspects, embodiments disclosed herein have a microbial organism having a malonyl-CoA-independent fatty acid synthesis (FAS) pathway and an acyl-reduction pathway, having at least one exogenous nucleic acid encoding a malonyl-CoA-independent FAS pathway enzyme expressed in sufficient amounts to produce a primary alcohol.

    摘要翻译： 要解决的问题：提供产生伯醇的生物体。解决方案：本发明提供了具有至少一种外源基因插入和/或一种或多种赋予伯醇生产的基因破坏的非天然存在的微生物生物。 生产伯醇的方法包括培养非天然存在的微生物。 在一些方面，本文公开的实施方案具有具有丙二酰辅酶A非依赖性脂肪酸合成（FAS）途径和酰基还原途径的微生物生物，其具有至少一种编码不依赖丙二酰辅酶A的FAS途径酶的外源核酸，所述外源核酸表达 足够量产生伯醇。