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    Composition having brain cell-activating effect by virtue of ginkgo leaf extract nano fine particle
    75.
    发明专利
    Composition having brain cell-activating effect by virtue of ginkgo leaf extract nano fine particle 有权
    具有银杏叶提取物的细胞活化作用的组合物纳米微粒

    公开(公告)号：JP2007277183A

    公开(公告)日：2007-10-25

    申请号：JP2006106821

    申请日：2006-04-07

    申请人： Shinji Shimada ,  伸司 嶋田

    发明人： SHIMADA SHINJI

    IPC分类号： A61K36/00 ,  A23L1/22 ,  A23L1/30 ,  A61P9/00 ,  A61P9/10 ,  A61P9/14 ,  A61P25/00 ,  A61P25/28 ,  A61P43/00

    CPC分类号： A61K9/14 ,  A61K36/16

    摘要： PROBLEM TO BE SOLVED: To provide a ginkgo leaf extract which does not contain ginkgolic acid, contains conventional ginkgo leaf extract active ingredients, and exhibits a remarkable effect for activating brain cells. SOLUTION: This composition having a brain function-activating effect contains nano fine particle ginkgo leaf extract as an active ingredient. The ginkgo leaf extract not containing ginkgolic acid and produced by a breakdown method for crushing ginkgo leaf extract powder by a combination of a dry method with a wet method. The nano fine particles are ≤100 nm fine particles. The composition has a form selected from the group consisting of a seasoning, a food additive, a food raw material, a food, a drink, a health food, a health drink, a medicine/quasi drug, and a feed. The health food or drink is a food or drink which prevents or improves symptoms with a brain function-activating effect and is useful for patients having brain circulation metabolism disorders. The medicine/quasi drug is used for human or animals. COPYRIGHT: (C)2008,JPO&INPIT

    摘要翻译： 待解决的问题：提供不含银杏酸的银杏叶提取物，含有常规的银杏叶提取物活性成分，并且对于激活脑细胞显示出显着的效果。 解决方案：具有脑功能活化作用的组合物含有纳米细粒银杏叶提取物作为活性成分。 银杏叶提取物不含银杏酸，通过干法与湿法联合破碎银杏叶提取物粉碎的破碎方法制备。 纳米微粒为≤100nm的微粒。 该组合物具有选自调味料，食品添加剂，食品原料，食品，饮料，保健食品，保健饮料，药物/准药品和饲料的形式。 保健食品或饮料是防止或改善具有脑功能活化作用的症状的食物或饮料，并且对于具有脑循环代谢障碍的患者是有用的。 药物/准药物用于人或动物。 版权所有（C）2008，JPO＆INPIT

    Use of ginkgo extract
    77.
    发明专利
    Use of ginkgo extract 审中-公开
    银杏提取物的使用

    公开(公告)号：JP2007126472A

    公开(公告)日：2007-05-24

    申请号：JP2006345847

    申请日：2006-12-22

    申请人： Georgetown Univ ,  Soc De Conseils De Recherches & D'applications Scientifiques Sas ,  ジョージタウン・ユニバーシティ ,  ソシエテ・ドゥ・コンセイユ・ドゥ・ルシェルシュ・エ・ダプリカーション・シャンティフィック・エス・ア・エス

    发明人： DRIEU KATY ,  PAPADOPOULOS VASSILIOS

    IPC分类号： A61K31/365 ,  A61K20060101 ,  A61K36/00 ,  A61K36/16 ,  A61P35/00 ,  A61P43/00 ,  C07D493/18

    CPC分类号： A61K36/16

    摘要： PROBLEM TO BE SOLVED: To provide a new medicine for decreasing the proliferation of tumor cells. SOLUTION: The present invention is directed to a medicine using the extract of Ginkgo biloba leaves or isolated ginkgolide B (GKB), a component of the extract of Ginkgo biloba leaves in a method for decreasing the expression of peripheral-type benzodiazepine receptor (PBR) in cells of a patient in need thereof. Further, the present invention is directed to the use of the extract of Ginkgo biloba leaves or isolated GKB in a method of decreasing cancer cell proliferation in a patient, wherein the cancer cell is human breast cancer cell. Even more particularly, the present invention is directed to the use of the extract of Ginkgo biloba leaves or isolated GKB in method of decreasing cancer cell proliferation in a patient wherein the cancer cell is of the infiltrating and invasive phenotype and expresses high levels of PBR in comparison to non-invasive cancer cell. COPYRIGHT: (C)2007,JPO&INPIT

    摘要翻译： 要解决的问题：提供一种降低肿瘤细胞增殖的新药。 解决方案：本发明涉及一种使用银杏叶提取物或分离的银杏内酯B（GKB）的药物，其是在降低外周型苯并二氮杂受体表达的方法中银杏叶提取物的组分 （PBR）在需要的患者的细胞中。 此外，本发明涉及银杏叶提取物或分离的GKB在减少患者癌细胞增殖的方法中的用途，其中癌细胞是人乳腺癌细胞。 更具体地，本发明涉及银杏提取物或分离的GKB在降低癌细胞增殖的方法中的用途，其中癌细胞是浸润和侵袭性表型，并且表达高水平的PBR 与非侵袭性癌细胞的比较。 版权所有（C）2007，JPO＆INPIT