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    Neovascular-targeted immunoconjugate
    2.
    发明专利
    Neovascular-targeted immunoconjugate 有权
    NEOVASCULAR-TARIGTED IMMUNOCONJUGATE

    公开(公告)号：JP2012255032A

    公开(公告)日：2012-12-27

    申请号：JP2012213338

    申请日：2012-09-27

    Applicant: Yale Univ ,  エール ユニバーシティ

    Inventor： GAREN ALAN

    IPC: A61K39/395 ,  C12N15/09 ,  A61K35/76 ,  A61K38/00 ,  A61K38/43 ,  A61K48/00 ,  A61P9/10 ,  A61P19/02 ,  A61P27/02 ,  A61P29/00 ,  A61P35/00 ,  C07K14/47 ,  C07K16/00 ,  C07K16/18 ,  C07K16/30 ,  C07K16/46

    CPC classification number: C07K16/3053 ,  A61K2039/505 ,  C07K2317/622 ,  C07K2319/00 ,  C07K2319/30

    Abstract: PROBLEM TO BE SOLVED: To provide immunoconjugates for treating diseases associated with neovascularization such as cancer, rheumatoid arthritis, the exudative form of macular degeneration, and atherosclerosis.SOLUTION: The immunoconjugates typically consist of the Fc region of a human IgG1 immunoglobulin including a hinge, or other effector domain or domains that can elicit, when administered to a patient, a cytolytic immune response or cytotoxic effect against a targeted cell. The effector domain is conjugated to a targeting domain which comprises a factor VII mutant that binds with high affinity and specificity to tissue factor but does not initiate blood clotting such as factor VII having a substitution of alanine for lysine-341 or of alanine for serine-344.

    Abstract translation: 要解决的问题：提供用于治疗与新血管形成相关的疾病如癌症，类风湿性关节炎，渗出性黄斑变性和动脉粥样硬化的免疫缀合物。 解决方案：免疫缀合物通常由人IgG1免疫球蛋白的Fc区组成，包括铰链，或当向患者施用对靶细胞的细胞溶解免疫应答或细胞毒性作用时可引发的其他效应结构域或结构域。 效应结构域与靶向结构域结合，该靶向结构域包含以组合因子的高亲和性和特异性结合但不引发血液凝固的因子VII突变体，例如具有丙氨酸取代赖氨酸341或丙氨酸的丝氨酸 - 344。 版权所有（C）2013，JPO＆INPIT

    Ribozyme-amplifying diagnosis medicine
    9.
    发明专利
    Ribozyme-amplifying diagnosis medicine 审中-公开
    RIBOZYME-AMPLIFYING诊断医学

    公开(公告)号：JP2004000281A

    公开(公告)日：2004-01-08

    申请号：JP2003310777

    申请日：2003-09-02

    Applicant: Innovir Lab Inc ,  Univ Yale ,  イノーバー ラボラトリーズ,インコーポレイテッド ,  エール・ユニバーシティ

    Inventor： SHIH ANDY ,  BOCKMAN JEFFREY M ,  GEORGE SHAJI T

    IPC: G01N33/53 ,  C07H21/04 ,  C12N15/09 ,  C12N15/113 ,  C12Q1/68 ,  G01N33/50 ,  G01N33/566

    CPC classification number: C12N15/113 ,  C12N2310/121 ,  C12N2310/3517 ,  C12Q1/6823 ,  C12Q2521/337

    Abstract: PROBLEM TO BE SOLVED: To provide a method for amplifying or preparing diagnosis response by using ribozyme. SOLUTION: The method is for detecting target nucleic acid molecules in a solvent and comprises, under a condition of hybridizing two complementary nucleotides in a solvent, a step for providing ribozyme molecules, target nucleic acid molecules and labelled co-target nucleic acid molecules having a cleavage site to the ribozyme, wherein the co-target molecules have a different sequence from that of the target molecules, the ribozyme molecules have a complementary region to the labelled nucleic acid molecule and a complementary region to the target nucleic acid molecule and the complementary region has at least minimum number of the complementary nucleotide to obtain conjugation between the ribozyme molecules, co-target nucleic acid molecules and the target nucleic acid molecules, a step for reacting the ribozyme molecules with the labelled co-target nucleic acid molecules and the target nucleic acid molecules and a step for detecting evidence of freed labels by comparing a case where no target nucleic acid is contained in the solvent with a case where the target nucleic acid molecules are contained in the solvent. COPYRIGHT: (C)2004,JPO

    Abstract translation: 待解决的问题：提供通过使用核酶扩增或制备诊断反应的方法。 解决方案：该方法用于检测溶剂中的靶核酸分子，并且在溶剂中与两个互补核苷酸杂交的条件下，提供提供核酶分子，靶核酸分子和标记的共靶核酸的步骤 分子具有到核酶的切割位点，其中共靶向分子具有与靶分子不同的序列，核酶分子与标记的核酸分子和靶核酸分子的互补区和与靶核酸分子的互补区， 互补区具有至少最小数量的互补核苷酸以获得核酶分子，共靶核酸分子和靶核酸分子之间的共轭，使核酶分子与标记的共靶核酸分子反应的步骤和 目标核酸分子和通过比较其中的情况来检测释放标签的证据的步骤 在溶剂中含有目标核酸分子的情况下，不存在目标核酸。 版权所有（C）2004，JPO

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