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    STABLE PREPARATION FOR CURING BLOOD COAGULATION DISEASE
    5.
    发明专利
    STABLE PREPARATION FOR CURING BLOOD COAGULATION DISEASE 失效

    公开(公告)号：JPH07304658A

    公开(公告)日：1995-11-21

    申请号：JP10945895

    申请日：1995-05-08

    申请人： IMMUNO AG

    发明人： EIBL JOHANN ,  SCHWARZ HANS PETER ,  SIEKMANN JUERGEN ,  TURECEK PETER

    IPC分类号： A61K9/127 ,  A61K9/14 ,  A61K38/43 ,  A61K38/48 ,  A61K38/55 ,  A61P7/02 ,  C12N9/64 ,  C12N9/96 ,  A61K9/19

    摘要： PURPOSE: To obtain the subject preparation, containing a protein lipid complex in a vesicular form, subjected to a treatment for the inactivation of potentially present viruses and useful for treating blood coagulation disorders containing a coagulation active protein. CONSTITUTION: This stable virally safe preparation contains a protein bound in and/or on lipid vesicles (preferably a coagulation active protein) and is subjected to a treatment for inactivation of potentially present viruses (preferably heat treatment). The preparation preferably contains a blood coagulation factor of an endogenous or an exogenous blood coagulation, preferably an active type blood coagulation factor (e.g. a vitamin K-dependent protein, IIa factor or VIIa factor). The preparation is useful for intravenous injection.

    PROCESSING OF SAMPLE CONTAINING LIPOPROTEIN
    6.
    发明专利
    PROCESSING OF SAMPLE CONTAINING LIPOPROTEIN 失效

    公开(公告)号：JPH07181182A

    公开(公告)日：1995-07-21

    申请号：JP24514794

    申请日：1994-10-11

    申请人： IMMUNO AG

    发明人： EEBUARUTO MORINARI ,  PEETAA PIHIRAA ,  HARUTOMUUTO RANGU

    IPC分类号： G01N33/53 ,  B01J19/00 ,  G01N33/531 ,  G01N33/92

    摘要： PURPOSE: To reduce turbidity inherent to a biochemical fluid and analyze an antigen in a sample without fail by using a sample conditioner composed of a dilution buffer solution containing amino acid and an antibody against an antigen to be measured. CONSTITUTION: This method uses a sample conditioner composed of a dilution buffer solution containing amino acid and an antibody against lipoprotein to be measured, so as to treat a lipoprotein contained sample and measure an antigen with the immunoassay. In this case, the dilution cushion buffer is effective, when made to further contain a reactive accelerator, for example, polyethylene glycol. Also, the concentration of the amino acid is between 0.05M and 3M, or preferably between 0.1M and 0.5M. Proline is particularly suitable for removing the turbidity of a hyperlipemia sample or a turbid sample, regardless of the pre-treatment of the sample. Also, the first sample conditioner component containing a buffer material and amino acid, and the second sample conditioner component containing an antibody against an antigen to be measured with the immunoassay are used as a conditioning kit.