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公开(公告)号：JP2013039425A
公开(公告)日：2013-02-28
申请号：JP2012242985
申请日：2012-11-02
发明人： GRIFFITH MAY , LI FENGFU , LIU WENGUANG , RAFAT MERHDAD
CPC分类号： A61L27/52 , A61K9/0051 , A61K9/06 , A61K47/36 , A61K47/42 , A61L27/14 , C08F283/00 , C08F283/06 , C08J3/246 , C08J2300/16 , C08L5/00 , C08L5/04 , C08L5/08 , C08L33/14 , C08L89/00 , C08L89/04 , C08L89/06 , C08L2205/04 , C08L2666/02 , C08L2666/26
摘要： PROBLEM TO BE SOLVED: To provide interpenetrating polymer networks (IPNs), and related methods and compositions.SOLUTION: A hydrogel material comprises an interpenetrating network of two or more polymer networks, wherein at least one of the polymer networks is based on a biopolymer. Moreover, a method for producing the hydrogel material comprising, combining a first polymer network with a second polymer network, wherein the first polymer network or the second polymer network is based on a biopolymer. The present application also discloses devices manufactured from the IPN hydrogel material and uses thereof.
摘要翻译： 要解决的问题：提供互穿聚合物网络（IPN）以及相关方法和组成。 解决方案：水凝胶材料包括两个或多个聚合物网络的互穿网络，其中至少一个聚合物网络基于生物聚合物。 此外，一种生产水凝胶材料的方法，包括将第一聚合物网络与第二聚合物网络结合，其中第一聚合物网络或第二聚合物网络基于生物聚合物。 本申请还公开了由IPN水凝胶材料制造的装置及其用途。 版权所有（C）2013，JPO＆INPIT
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公开(公告)号：JP2013075921A
公开(公告)日：2013-04-25
申请号：JP2013013166
申请日：2013-01-28
发明人： ATKINS HAROLD L , BELL JOHN C , HEILMAN CONRAD J JR , LICHTY BRIAN D , LORENCE ROBERT M , ROBERTS MICHAEL S , STOJDL DAVID F
IPC分类号： A61K35/12 , A61K45/00 , A61K35/14 , A61K35/28 , A61K35/76 , A61K38/00 , A61P25/00 , A61P29/00 , A61P35/00 , A61P35/02 , A61P37/02 , A61P37/06 , C12N5/00 , C12N5/06 , C12N5/08
CPC分类号： C12N5/0093 , A61K35/14 , A61K35/28 , A61K35/765 , A61K35/766 , A61K35/768 , C12N2501/24 , A61K2300/00
摘要： PROBLEM TO BE SOLVED: To provide a method for reducing or eliminating neoplastic cells in an ex vivo mixture of normal hematopoeitic cells and neoplastic cells.SOLUTION: There is provided the method by bringing the mixture of cells into contact with a virus. In one aspect, the virus is an RNA virus. In one aspect, the neoplastic cells are leukemia cells. In one aspect, the hematopoietic cells are marrow cells. In one aspect, the hematopoietic cells are peripheral blood cells. In one aspect, the RNA virus is a single-stranded RNA virus. In one aspect, the single-stranded RNA virus is a non-segmented, negative sense RNA virus.
摘要翻译： 待解决的问题：提供在正常造血细胞和肿瘤细胞的离体混合物中减少或消除肿瘤细胞的方法。 解决方案：通过使细胞混合物与病毒接触来提供该方法。 一方面，病毒是RNA病毒。 一方面，肿瘤细胞是白血病细胞。 一方面，造血细胞是骨髓细胞。 一方面，造血细胞是外周血细胞。 一方面，RNA病毒是单链RNA病毒。 在一个方面，单链RNA病毒是非分段的负义RNA病毒。 版权所有（C）2013，JPO＆INPIT
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3.发明专利Inhibitor protein of neuronal apoptosis, gene sequence thereof and mutation of the same gene causative of spinal muscular atrophy 有权神经病毒抑制剂蛋白质，基因序列及其相同基因的脊髓灰质病变的基因突变
公开(公告)号：JP2007289183A
公开(公告)日：2007-11-08
申请号：JP2007097099
申请日：2007-04-03
发明人： MACKENZIE ALEX E , KORNELUK ROBERT G , MAHADEVAN MANI S , MICHAEL MCLEAN , ROY NATALIE , IKEDA SHIGEMORI
CPC分类号： C07K14/4747 , C12Q1/6883 , G01N33/6896
摘要： PROBLEM TO BE SOLVED: To provide a method for diagnosing spinal muscular atrophy on the basis of deletion of a neuronal apoptosis inhibitor protein gene. SOLUTION: It is found that the gene for spinal muscular atrophy which is an autosomal recessive neurodegenerative disorder is mapped to a region of chromosome 5. Since the gene encodes a protein having homology with apoptosis inhibitor proteins of viruses, the encoded protein is specified as an NAIP (neuronal apoptosis inhibitor protein). A deletion is recognized in the NAIP region in patients suffering from the spinal muscular atrophy and not in the normal population. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译： 要解决的问题：提供一种基于神经元凋亡抑制蛋白基因缺失来诊断脊髓性肌萎缩的方法。 解决方案：发现作为常染色体隐性神经退行性疾病的脊髓性肌萎缩基因被定位于染色体5的区域。由于该基因编码与病毒的凋亡抑制蛋白具有同源性的蛋白质，编码的蛋白质 指定为NAIP（神经元凋亡抑制蛋白）。 在患有脊髓性肌萎缩的患者的NAIP区域中识别出缺失，而不在正常人群中。 版权所有（C）2008，JPO＆INPIT
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4.发明专利Neuronal apoptosis inhibitory protein, its gene sequence and mutations of gene causative of spinal muscular atrophy 审中-公开神经病毒抑制蛋白，其基因序列和突变的基因引起的脊髓弹性蛋白
公开(公告)号：JP2006025797A
公开(公告)日：2006-02-02
申请号：JP2005241922
申请日：2005-08-24
发明人： MACKENZIE ALEX E , KORNELUK ROBERT G , MAHADEVAN MANI S , MICHAEL MCLEAN , ROY NATALIE , IKEDA SHIGEMORI
CPC分类号： C07K14/4747 , C12Q1/6883 , G01N33/6896
摘要： PROBLEM TO BE SOLVED: To provide a diagnostic method for spinal muscular atrophy due to deletion of neuronal apoptosis inhibitory protein gene. SOLUTION: The gene for autosomal recessive neurodegenerative disorder spinal muscular atrophy has been found to be mapped to a region of chromosome 5. The gene encodes a protein having homology with apoptosis inhibitory proteins of viruses so that the encoded protein has been labelled as a neuronal apoptosis inhibitory protein (NAIP). Deletion in the NAIP domain was identified in patients with spinal muscular atrophy and not in the normal population. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译： 要解决的问题：提供由于神经元凋亡抑制蛋白基因缺失引起的脊髓性肌肉萎缩的诊断方法。 解决方案：已经发现常染色体隐性遗传性神经退行性疾病脊髓性肌萎缩症的基因被映射到染色体5的区域。该基因编码与病毒的凋亡抑制蛋白具有同源性的蛋白质，使得编码的蛋白质被标记为 神经元凋亡抑制蛋白（NAIP）。 在脊髓性肌萎缩的患者中确定NAIP结构域中的缺失，而不在正常人群中。 版权所有（C）2006，JPO＆NCIPI
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