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公开(公告)号：JPWO2005063293A1
公开(公告)日：2007-07-19
申请号：JP2005516655
申请日：2004-12-24
IPC分类号： A61K45/00 , H04M1/02 , A61K31/4409 , A61K31/4439 , A61K31/4453 , A61K31/4545 , A61K31/455 , A61K31/5377 , A61K31/55 , A61K48/00 , A61P11/00 , A61P31/12 , A61P31/14 , A61P31/16 , A61P31/18 , A61P31/22 , A61P43/00 , C07D213/81 , C07D213/82 , C07D213/83 , C07D295/12 , C07D401/12 , C12N15/113 , H04M1/21
CPC分类号： A61K31/444 , A61K31/4409 , A61K31/4439 , A61K31/4453 , A61K31/4545 , A61K31/455 , A61K31/5377 , A61K31/55 , C07D211/14 , C07D213/81 , C07D213/82 , C07D401/12 , C12N15/1137
摘要： 本願発明は、(1)SR蛋白質の活性を低減又は阻害することによる抗ウイルス剤、より具体的には、(i)SR蛋白質の脱リン酸化を促進させることによる抗ウイルス剤、及び(ii)SR蛋白質をリン酸化させる蛋白質を阻害することによる抗ウイルス剤、更に(2)SR蛋白質の発現を阻害することによる抗ウイルス剤、並びに、(3)SR蛋白質と逆の機能をする蛋白質を活性化することによる抗ウイルス剤を提供する。また本発明は、SR蛋白質をリン酸化させるSRPKを阻害する化合物を提供する。これらの化合物は、SR蛋白質の活性を阻害し抗ウイルス作用を示す。本発明は、SARSをはじめ、種々の新規なウイルスの出現に伴い、新規なウイルスにも対応できる、適用性が広く、しかも、持続性の高い抗ウイルス剤を提供する。
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公开(公告)号：JP4771468B2
公开(公告)日：2011-09-14
申请号：JP2005516655
申请日：2004-12-24
申请人： 正敏 萩原
IPC分类号： A61K31/4523 , H04M1/02 , A61K31/4406 , A61K31/4409 , A61K31/4439 , A61K31/4453 , A61K31/4545 , A61K31/455 , A61K31/5377 , A61K31/55 , A61P31/12 , A61P31/16 , A61P31/18 , A61P31/22 , C07D213/81 , C12N15/113 , H04M1/21
CPC分类号： A61K31/444 , A61K31/4409 , A61K31/4439 , A61K31/4453 , A61K31/4545 , A61K31/455 , A61K31/5377 , A61K31/55 , C07D211/14 , C07D213/81 , C07D213/82 , C07D401/12 , C12N15/1137
摘要： The present invention provides: (1) antiviral agents that act by reducing or inhibiting the activity of SR proteins, more specifically, (i) antiviral agents that act by enhancing dephosphorylation of SR proteins, and (ii) antiviral agents that act by inhibiting proteins that phosphorylate SR proteins; (2) antiviral agents that act by inhibiting the expression of SR proteins, and (3) antiviral agents that act by activating proteins that antagonize SR proteins. The present invention also provides compounds that inhibit SRPKs, which phosphorylate SR proteins. Such compounds inhibit the activity of SR proteins and have antiviral activities. Various new viruses including SARS have emerged, and thus the present invention provides long-lasting broad-spectrum antiviral agents applicable to new viruses.
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公开(公告)号：JP5227390B2
公开(公告)日：2013-07-03
申请号：JP2010276982
申请日：2010-12-13
申请人： 正敏 萩原
IPC分类号： A61K31/4453 , H04M1/02 , A61K31/4409 , A61K31/4439 , A61K31/4545 , A61K31/455 , A61K31/5377 , A61K31/55 , A61P31/12 , A61P43/00 , C07D213/81 , C07D213/82 , C07D213/83 , C07D295/06 , C07D295/12 , C07D401/12 , C12N15/113 , H04M1/21
CPC分类号： A61K31/444 , A61K31/4409 , A61K31/4439 , A61K31/4453 , A61K31/4545 , A61K31/455 , A61K31/5377 , A61K31/55 , C07D211/14 , C07D213/81 , C07D213/82 , C07D401/12 , C12N15/1137
摘要： The present invention provides: (1) antiviral agents that act by reducing or inhibiting the activity of SR proteins, more specifically, (i) antiviral agents that act by enhancing dephosphorylation of SR proteins, and (ii) antiviral agents that act by inhibiting proteins that phosphorylate SR proteins; (2) antiviral agents that act by inhibiting the expression of SR proteins, and (3) antiviral agents that act by activating proteins that antagonize SR proteins. The present invention also provides compounds that inhibit SRPKs, which phosphorylate SR proteins. Such compounds inhibit the activity of SR proteins and have antiviral activities. Various new viruses including SARS have emerged, and thus the present invention provides long-lasting broad-spectrum antiviral agents applicable to new viruses.
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