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    Placental stem cell population
    2.
    发明专利
    Placental stem cell population 有权
    普通干细胞群体

    公开(公告)号：JP2013099343A

    公开(公告)日：2013-05-23

    申请号：JP2013002575

    申请日：2013-01-10

    Applicant: Anthrogenesis Corp ,  アントフロゲネシス コーポレーション

    Inventor： EDINGER JAMES W ,  HARIRI ROBERT J ,  WANG JIA-LUN ,  YE QIAN

    IPC: C12N5/10 ,  A61K35/50 ,  A61P7/00 ,  C12N5/073 ,  C12N5/0735 ,  C12N5/074

    CPC classification number: A61K35/50 ,  A61K9/0019 ,  A61K35/644 ,  A61K38/21 ,  A61K45/06 ,  A61K2035/122 ,  C12N5/0605 ,  C12N5/0607 ,  C12N2500/25 ,  C12N2500/36 ,  C12N2500/42 ,  C12N2501/11 ,  C12N2501/135 ,  C12N2501/39 ,  C12N2533/52 ,  A61K2300/00

    Abstract: PROBLEM TO BE SOLVED: To provide isolated placental stem cells, populations of placental stem cells, compositions comprising the stem cells, and methods for obtaining the stem cells.SOLUTION: The invention provides isolated stem cells, and cell populations comprising such stem cells, wherein the stem cells are isolatable from placental tissue (e.g., amnion, chorion, placental lobe, etc.). The placental stem cells exhibit one or more characteristics of a stem cell (e.g., exhibit markers associated with stem cells, replicate at least 10-20 times in culture state in an undifferentiated state, differentiate into adult cells representative of the three germ layers, etc.), and can adhere to a tissue culture substrate (e.g., tissue culture plastic such as the surface of a tissue culture dish or multiwell plate).

    Abstract translation: 待解决的问题：提供分离的胎盘干细胞，胎盘干细胞群，包含干细胞的组合物和获得干细胞的方法。 解决方案：本发明提供了分离的干细胞和包含这种干细胞的细胞群，其中干细胞可从胎盘组织（例如，羊膜，绒毛膜，胎盘等）分离。 胎盘干细胞表现出干细胞的一个或多个特征（例如，显示与干细胞相关的标记，在未分化状态下在培养状态下复制至少10-20次，分化成代表三个胚层的成体细胞等 ），并且可以粘附到组织培养基底（例如，组织培养塑料，例如组织培养皿或多孔板的表面）。 版权所有（C）2013，JPO＆INPIT

    Immunomodulation using placental stem cell
    3.
    发明专利
    Immunomodulation using placental stem cell 审中-公开
    使用平面干细胞进行免疫调节

    公开(公告)号：JP2013064003A

    公开(公告)日：2013-04-11

    申请号：JP2012265040

    申请日：2012-12-04

    Applicant: Anthrogenesis Corp ,  アントフロゲネシス コーポレーション

    Inventor： PALUDAN CASPER ,  EDINGER JAMES ,  HARBACHEUSKI RYHOR ,  MURRAY ROSEANN ,  HARIRI ROBERT J

    IPC: A61K35/50 ,  A61P37/06 ,  C12N5/073

    CPC classification number: A61K35/50 ,  C12N5/0605 ,  C12N5/0668 ,  C12N2502/11

    Abstract: PROBLEM TO BE SOLVED: To provide methods of immunomodulation using placental stem cells and placental stem cell populations.SOLUTION: The placental stem cells: express CD200 and HLA-G; express CD73, CD105, and CD200; express CD200 and OCT-4; express CD73, CD105, and HLA-G; express CD73 and CD105 and facilitate the formation of one or more embryoid-like bodies in a population of placental cells that comprises the plurality of placental stem cells when the population is cultured under conditions that allow formation of embryoid-like bodies; and/or express OCT-4 and facilitate the formation of one or more embryoid-like bodies in a population of placental cells that comprises the plurality of placental stem cells, when the population is cultured under conditions that allow formation of embryoid-like bodies.

    Abstract translation: 要解决的问题：提供使用胎盘干细胞和胎盘干细胞群的免疫调节方法。 解决方案：胎盘干细胞：表达CD200和HLA-G; 表达CD73，CD105和CD200; 表达CD200和OCT-4; 表达CD73，CD105和HLA-G; 表达CD73和CD105，并且当在允许形成类胚体的条件下培养群体时，促进在包含多个胎盘干细胞的胎盘细胞群中形成一个或多个类胚样体; 和/或表达OCT-4，并且当所述群体在允许形成类胚体的条件下培养时，促进包含多个胎盘干细胞的胎盘细胞群体中一种或多种类胚样体的形成。 版权所有（C）2013，JPO＆INPIT

    Collagen biofabric and method of preparation and use therefor
    4.
    发明专利
    Collagen biofabric and method of preparation and use therefor 有权
    COLLAGEN BIOFABRIC及其制备和使用方法

    公开(公告)号：JP2010265298A

    公开(公告)日：2010-11-25

    申请号：JP2010156978

    申请日：2010-07-09

    Applicant: Anthrogenesis Corp ,  アンスロジェネシス コーポレーション

    Inventor： HARIRI ROBERT J ,  KAPLUNOVSKY ALEKSANDR M ,  MURPHY PATRICIA A

    IPC: C07K14/78 ,  A61K38/17 ,  A61K47/42 ,  A61L27/00 ,  A61L27/36 ,  A61P13/02 ,  A61P17/00 ,  A61P17/02 ,  A61P27/02 ,  A61P41/00 ,  C07K1/14 ,  C12N5/00

    CPC classification number: C12N5/0068 ,  A61K35/50 ,  A61L27/3604 ,  A61L27/3683 ,  A61L27/3691 ,  A61L2430/40 ,  C12N2533/92 ,  Y10T442/2525

    Abstract: PROBLEM TO BE SOLVED: To provide a method for preparing a collagen biofabric from a placental membrane (preferably human placental membrane) having a chorionic and amniotic membrane, by decellularizing the amniotic membrane. SOLUTION: There is provided a method for preparing a collagen biofabric from a placental membrane having a chorionic and amniotic membrane, wherein the method comprises (a) a step for isolating the amniotic membrane from the chorionic membrane; and (b) a step for decellularizing the amniotic membrane not to contact the amniotic membrane to the enzyme. The collagen biofabric has numerous utilities in the medical and surgical field including for example, blood vessel repair, construction and replacement of a blood vessel, tendon and ligament replacement, wound-dressing, surgical grafts, ophthalmic uses, sutures, and others. COPYRIGHT: (C)2011,JPO&INPIT

    Abstract translation: 要解决的问题：通过使羊膜脱细胞，提供从具有绒毛膜和羊膜的胎盘膜（优选人胎盘膜）制备胶原蛋白生物制剂的方法。 提供了从具有绒毛膜和羊膜的胎盘膜制备胶原生物制剂的方法，其中所述方法包括（a）从绒毛膜分离羊膜的步骤; 和（b）用于使羊膜脱细胞不与羊膜接触的步骤。 胶原蛋白生物制剂在医疗和外科领域中具有许多用途，包括例如血管修复，血管构造和置换，肌腱和韧带替代，伤口敷料，手术移植物，眼用途，缝合线等。 版权所有（C）2011，JPO＆INPIT

    Collagen biofabric and preparation method and use therefor
    5.
    发明专利
    Collagen biofabric and preparation method and use therefor 有权
    COLLAGEN BIOFABRIC和制备方法及其应用

    公开(公告)号：JP2014138590A

    公开(公告)日：2014-07-31

    申请号：JP2014016360

    申请日：2014-01-31

    Applicant: Anthrogenesis Corp ,  アンスロジェネシス コーポレーション

    Inventor： HARIRI ROBERT J ,  KAPLUNOVSKY ALEKSANDR M ,  MURPHY PATRICIA A

    IPC: C12P21/00 ,  A61K31/5575 ,  A61K31/7008 ,  A61K33/00 ,  A61K38/00 ,  A61K38/22 ,  A61K38/43 ,  A61K39/00 ,  A61K45/00 ,  A61K47/32 ,  A61K47/34 ,  A61K47/36 ,  A61K47/42 ,  A61L27/00 ,  A61L27/36 ,  A61P17/00 ,  A61P17/02 ,  A61P27/02 ,  C12N5/00 ,  C12N5/071 ,  C12N5/074 ,  C12N5/0775 ,  C12N5/10

    CPC classification number: C12N5/0068 ,  A61K35/50 ,  A61L27/3604 ,  A61L27/3683 ,  A61L27/3691 ,  A61L2430/40 ,  C12N2533/92 ,  Y10T442/2525

    Abstract: PROBLEM TO BE SOLVED: To provide collagenous membranes produced from amnion, and to provide a method for preparing a three-dimensional scaffold for forming a surgical graft.SOLUTION: A collagen biofabric of the invention has the structural integrity of the native non-treated amniotic membrane, i.e., the native tertiary and quaternary structure. The present invention provides a method for preparing the collagen biofabric from a placental membrane, preferably a human placental membrane, having a chorionic and amniotic membrane, by decellularizing the amniotic membrane. In a preferred embodiment, the amniotic membrane is completely decellularized. The collagen biofabric of the invention has numerous utilities in the medical and surgical field including for example, blood vessel repair, construction and replacement of a blood vessel, tendon and ligament replacement, wound-dressing, surgical grafts, ophthalmic uses, sutures and the like. The benefits of the biofabric are, in part, due to its physical properties such as biomechanical strength, flexibility, suturability, and low immunogenicity, particularly when derived from human placenta.

    Abstract translation: 要解决的问题：提供由羊膜制成的胶原膜，并提供一种制备用于形成手术移植物的三维支架的方法。解决方案：本发明的胶原生物制品具有天然未处理的羊膜的结构完整性 膜，即天然三级和四级结构。 本发明提供了通过使羊膜脱细胞从胎盘膜（优选人胎盘膜）制备具有绒毛膜和羊膜的胶原生物制剂的方法。 在优选的实施方案中，羊膜完全脱细胞。 本发明的胶原生物制剂在医疗和外科领域中具有许多用途，包括例如血管修复，血管的构造和替换，腱和韧带替代，伤口敷料，手术移植物，眼用途，缝合线等 。 生物制品的优点部分是由于其物理性质如生物力学强度，柔韧性，可渗透性和低免疫原性，特别是当衍生自人胎盘时。

    Post-partum mammalian placenta, its use and placental stem cell therefrom
    7.
    发明专利
    Post-partum mammalian placenta, its use and placental stem cell therefrom 审中-公开
    邮政编码：MAMMALIAN PLACENTA，其使用和其他干细胞

    公开(公告)号：JP2013208135A

    公开(公告)日：2013-10-10

    申请号：JP2013128034

    申请日：2013-06-19

    Applicant: Anthrogenesis Corp ,  アンスロジェネシス コーポレーション

    Inventor： HARIRI ROBERT J

    IPC: C12N5/0735 ,  A61M1/02 ,  C12N5/00 ,  C12N5/073

    CPC classification number: A61K35/50 ,  A61K35/12 ,  A61L27/3695 ,  A61L27/3834 ,  A61L2430/34 ,  A61M1/02 ,  A61M2202/0462 ,  A61M2210/1458 ,  A61M2210/1466 ,  C12N5/0068 ,  C12N5/0605 ,  C12N5/0606 ,  C12N5/0663 ,  C12N5/0678 ,  C12N2509/00 ,  C12N2513/00 ,  C12N2533/90

    Abstract: PROBLEM TO BE SOLVED: To provide a method for extracting and recovering embryonic-like stem cells, such as pluripotent or multipotent stem cells, from an exsanguinated human placenta.SOLUTION: A placenta is treated to remove residual umbilical cord blood by perfusing an exsanguinated placenta, preferably with an anticoagulant solution, to flush out residual cells. The residual cells and perfusion liquid from the exsanguinated placenta are collected, and the embryonic-like stem cells are separated from the residual cells and perfusion liquid. The invention also provides a method for utilizing the isolated and perfused placenta as a bioreactor to propagate endogenous cells, including, but not limited to, embryonic-like stem cells. The invention also provides methods for propagating endogenous cells in a placental bioreactor and collecting the propagated endogenous cells and bioactive molecules therefrom.

    Abstract translation: 要解决的问题：提供从放血的人胎盘中提取和回收胚胎样干细胞例如多能干细胞或多能干细胞的方法。解决方案：通过灌注放血胎盘来处理胎盘以除去残留的脐带血 ，优选用抗凝血剂溶液冲洗掉残留的细胞。 收集来自放血胎盘的残留细胞和灌注液，从残留细胞和灌注液中分离胚胎样干细胞。 本发明还提供了一种利用分离和灌注的胎盘作为生物反应器来繁殖内源细胞的方法，所述内源细胞包括但不限于胚胎样干细胞。 本发明还提供了在胎盘生物反应器中繁殖内源性细胞并从其中收集繁殖的内源细胞和生物活性分子的方法。

    Post-partum mammalian placenta, its use and placental stem cell originated therefrom
    10.
    发明专利
    Post-partum mammalian placenta, its use and placental stem cell originated therefrom 审中-公开
    后处理乳腺癌，其使用和特异性干细胞

    公开(公告)号：JP2010000085A

    公开(公告)日：2010-01-07

    申请号：JP2009188480

    申请日：2009-08-17

    Applicant: Anthrogenesis Corp ,  アンスロジェネシス コーポレーション

    Inventor： HARIRI ROBERT J

    IPC: C12N5/07 ,  A61K35/14 ,  A61K35/28 ,  A61K35/50 ,  A61M1/02 ,  A61P7/00 ,  A61P7/06 ,  A61P43/00 ,  C12M1/34 ,  C12N5/00 ,  C12N5/073

    CPC classification number: A61K35/50 ,  A61K35/12 ,  A61L27/3695 ,  A61L27/3834 ,  A61L2430/34 ,  A61M1/02 ,  A61M2202/0462 ,  A61M2210/1458 ,  A61M2210/1466 ,  C12N5/0068 ,  C12N5/0605 ,  C12N5/0606 ,  C12N5/0663 ,  C12N5/0678 ,  C12N2509/00 ,  C12N2513/00 ,  C12N2533/90

    Abstract: PROBLEM TO BE SOLVED: To provide a method of extracting and recovering embryonic-like stem cells, including, but not limited to pluripotent or multipotent stem cells, from an exsanguinated human placenta.
    SOLUTION: The placenta is treated to remove residual umbilical cord blood by perfusing the exsanguinated placenta, preferably with an anticoagulant solution, to flush out residual cells. The residual cells and perfusion liquid from the exsanguinated placenta are collected, and the embryonic-like stem cells are separated from the residual cells and perfusion liquid. The method of utilizing the isolated and perfused placenta as a bioreactor to propagate endogenous cells, including, but not limited to, embryonic-like stem cells is also provided. Further provided is the method for propagation of endogenous cells in a placental bioreactor and collecting the propagated endogenous cells and bioactive molecules therefrom.
    COPYRIGHT: (C)2010,JPO&INPIT

    Abstract translation: 待解决的问题：提供从放血的人胎盘中提取和回收胚胎样干细胞（包括但不限于多潜能或多能干细胞）的方法。

    解决方案：通过灌注放血的胎盘，优选用抗凝血剂溶液来处理胎盘以除去残留的脐带血，以冲洗残留的细胞。 收集来自放血胎盘的残留细胞和灌注液，从残留细胞和灌注液中分离胚胎样干细胞。 还提供了利用分离和灌注的胎盘作为生物反应器来繁殖内源细胞（包括但不限于胚胎样干细胞）的方法。 还提供了内源细胞在胎盘生物反应器中繁殖并从其中收集繁殖的内源细胞和生物活性分子的方法。 版权所有（C）2010，JPO＆INPIT

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