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公开(公告)号：JP2014133771A
公开(公告)日：2014-07-24
申请号：JP2014090162
申请日：2014-04-24
发明人： BURBAUM BEVERLY W , GILSON CHARLES A III , AYTES SHELLEY , ESTRADA SCOTT A , SENGUPTA DIPANJAN , SMITH BRIAN , REY MAX , WEIGL ULRICH
IPC分类号： C07D223/16 , A61K31/55 , A61P3/04 , A61P25/00 , A61P43/00 , C07B57/00 , C07B61/00 , C07C209/50 , C07C209/74 , C07C211/29 , C07C213/02 , C07C215/28 , C07C233/13
CPC分类号： C07D223/16 , C07C17/16 , C07C25/06 , C07C59/255 , C07C209/50 , C07C209/74 , C07C211/27 , C07C211/29 , C07C213/02 , C07C215/08 , C07C231/02 , C07C233/13
摘要： PROBLEM TO BE SOLVED: To provide processes and intermediates for the preparation of 3-benzazepines and salts thereof which can be useful as serotonin (5-HT) receptor agonists for the treatment of, for example, central nervous system disorders such as obesity.SOLUTION: Serotonin (5-HT) neurotransmission plays an important role in numerous physiological processes both in health disorders and in psychiatric disorders. For example, 5-HT has been implicated in the regulation of feeding behavior. 5-HT is believed to work by inducing a feeling of fullness, and thereby eating stops and fewer calories are taken.
摘要翻译： 要解决的问题：提供制备3-苯并氮杂及其盐的方法和中间体，其可用作5-羟色胺（5-HT）受体激动剂，用于治疗例如中枢神经系统疾病如肥胖症。解决方案 ：5-羟色胺（5-HT）神经传递在健康障碍和精神疾病中的许多生理过程中起重要作用。 例如，5-HT已经涉及饲养行为的调节。 5-HT被认为是通过诱发丰满的感觉来工作，从而吃掉停止并且摄取较少的热量。
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2.发明专利Processes for preparation of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates related thereto 有权制备8-氯代-1-甲基-2,3,4,5-四氢-1H-苯并嗪的方法及其相关的中间体
公开(公告)号：JP2013053164A
公开(公告)日：2013-03-21
申请号：JP2012274671
申请日：2012-12-17
发明人： WEIGL ULRICH , PORSTMANN FRANK , STRAESSLER CHRISTOPH , ULMER LARS , KOETZ ULF
IPC分类号： C07D223/16
CPC分类号： C07D223/16
摘要： PROBLEM TO BE SOLVED: To provide processes, methods and intermediates for the preparation of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine, salts, hydrates and crystal forms thereof.SOLUTION: The present invention provides processes and intermediates for preparing 8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine having Formula (I), salts and crystal form thereof. In some embodiments, the compound of formula (I) is the R enantiomer.
摘要翻译： 待解决的问题：提供制备8-氯-1-甲基-2,3,4,5-四氢-1H-3-苯并氮杂的盐，水合物及其晶体形式的方法和方法和中间体 。 解决方案：本发明提供了具有式（I）的8-氯-1-甲基-2,3,4,5-四氢-1H-3-苯并氮杂的盐和晶体形式的方法和中间体。 在一些实施方案中，式（I）化合物是R对映异构体。 版权所有（C）2013，JPO＆INPIT
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公开(公告)号：JP2012107067A
公开(公告)日：2012-06-07
申请号：JP2012049640
申请日：2012-03-06
发明人： BURBAUM BEVERLY W , GILSON CHARLES A III , AYTES SHELLEY , ESTRADA SCOTT A , SENGUPTA DIPANJAN , SMITH BRIAN , REY MAX , WEIGL ULRICH
IPC分类号： A61K31/55 , A61P3/04 , A61P25/00 , A61P43/00 , C07B57/00 , C07B61/00 , C07C59/255 , C07C209/50 , C07C209/74 , C07C211/29 , C07C213/02 , C07C215/08 , C07C231/02 , C07C233/13 , C07D223/16
CPC分类号： C07D223/16 , C07C17/16 , C07C25/06 , C07C59/255 , C07C209/50 , C07C209/74 , C07C211/27 , C07C211/29 , C07C213/02 , C07C215/08 , C07C231/02 , C07C233/13
摘要： PROBLEM TO BE SOLVED: To provide methods and intermediates for the preparation of 3-benzazepines and salts thereof which can be useful as serotonin (5-HT) receptor agonists for the treatment of, for example, central nervous system disorders such as obesity.SOLUTION: Serotonin (5-HT) neurotransmission plays an important role in numerous physiological processes both in health disorders and in psychiatric disorders. For example, 5-HT is implicated in the regulation of dieting behavior. 5-HT is believed to work by inducing a feeling of fullness or satiety so eating stops earlier and fewer calories are consumed.
摘要翻译： 待解决的问题：提供制备3-苯并氮杂及其盐的方法和中间体，其可用作5-羟色胺（5-HT）受体激动剂，用于治疗例如中枢神经系统疾病如 肥胖。 解决方案：5-羟色胺（5-HT）神经传递在健康障碍和精神疾病中的许多生理过程中起重要作用。 例如，5-HT涉及节食行为的调节。 5-HT被认为是通过诱发饱腹感或饱腹感来工作，因此早日停止饮食并消耗较少的热量。 版权所有（C）2012，JPO＆INPIT
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公开(公告)号：JP2011116780A
公开(公告)日：2011-06-16
申请号：JP2011049671
申请日：2011-03-07
发明人： BURBAUM BEVERLY W , GILSON CHARLES A III , AYTES SHELLEY , ESTRADA SCOTT A , SENGUPTA DIPANJAN , SMITH BRIAN , REY MAX , WEIGL ULRICH
IPC分类号： C07D223/16 , C07B57/00 , C07B61/00 , C07C59/255 , C07C209/08 , C07C209/50 , C07C209/74 , C07C209/84 , C07C211/29 , C07C215/08 , C07C231/02 , C07C233/13
CPC分类号： C07D223/16 , C07C17/16 , C07C25/06 , C07C59/255 , C07C209/50 , C07C209/74 , C07C211/27 , C07C211/29 , C07C213/02 , C07C215/08 , C07C231/02 , C07C233/13
摘要： PROBLEM TO BE SOLVED: To provide processes for preparing 3-benzazepines and salts thereof [which can be useful as serotonin (5-HT) receptor agonists for the treatment of, for example, central nervous system disorders (such as obesity)], and to provide intermediates therefor. SOLUTION: Serotonin (5-HT) neurotransmission fulfills an important role in various physiological processes in the both of health disorders and mental disorders. For example, 5-HT relates to control of abstemious diet behavior. The 5-HT is supposed to act by inducing feeling of fullness, and thereby meal is stopped and calorie to be taken in decreases. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译： 待解决的问题：提供制备3-苯并氮杂及其盐的方法[其可用作5-羟色胺（5-HT）受体激动剂，用于治疗例如中枢神经系统疾病（例如肥胖症） ]，并为其提供中间体。 解决方案：5-羟色胺（5-HT）神经传递在健康障碍和精神障碍的各种生理过程中起重要作用。 例如，5-HT涉及饮食行为的控制。 5-HT应该是通过诱导丰满的感觉来行动，从而停止膳食，减少卡路里。 版权所有（C）2011，JPO＆INPIT
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