公开(公告)号：JP2008222574A

公开(公告)日：2008-09-25

申请号：JP2007059268

申请日：2007-03-08

申请人： Chiba Univ ,  Fujitsu Ltd ,  国立大学法人 千葉大学 ,  富士通株式会社

发明人： TAMURA YUTAKA ,  HOSHINO CHUJI ,  FUJI HIDEYOSHI ,  ADACHI MUNEMORI ,  SHIOBARA NORIYUKI ,  SUGIYAMA HAJIME

IPC分类号： C40B30/02 ,  G06F19/00 ,  G06F19/16 ,  G06F19/28

摘要： PROBLEM TO BE SOLVED: To provide a molecular design device and the like for designing a molecule to be bonded to a target molecule in a short time at low cost or without requiring an advanced skill. SOLUTION: A processing unit 1 acquires a plurality of zero-th generation peptide data representing a peptide as the design object and a target molecule data representing the target molecule and specifies, for each candidate data, a numerical value that represents easiness of coupling between the peptide represented by the candidate data and the target molecule based on the candidate data and the target molecule data, and then selects a peptide having favorable characteristics of coupling with the molecule represented by the target molecule data from each candidate data based on the specified numerical value and according to predetermined standards, and generates a peptide data in the next generation representing a mutation of the selected peptide and further specifies a numerical value. COPYRIGHT: (C)2008,JPO&INPIT

摘要翻译： 要解决的问题：提供用于在短时间内以低成本设计要结合到靶分子的分子或不需要先进技术的分子设计装置等。 解决方案：处理单元1获取表示肽作为设计对象的多个第零代肽数据和表示目标分子的目标分子数据，并且为每个候选数据指定表示容易的数值 基于候选数据和靶分子数据，将由候选数据表示的肽与目标分子之间的偶联，然后基于候选数据选择具有与来自每个候选数据的目标分子数据所表示的分子的有利特征的肽 指定的数值并根据预定的标准，并产生代表所选肽的突变的下一代肽数据，并进一步指定数值。 版权所有（C）2008，JPO＆INPIT

公开(公告)号：JP2013230211A

公开(公告)日：2013-11-14

申请号：JP2012103379

申请日：2012-04-27

申请人： Tottori Univ ,  国立大学法人鳥取大学 ,  Chiba Univ ,  国立大学法人 千葉大学

发明人： OKAMOTO YOSHIHARU ,  TAMURA YUTAKA ,  SUGANAMI AKIKO ,  TOYODA TARO ,  HAYASHI HIDEKI ,  MADONO SATOYUKI ,  MATSUBARA HISAHIRO

IPC分类号： A61M37/00 ,  A61N5/06

摘要： PROBLEM TO BE SOLVED: To provide a non-invasive medical device utilizing the wavelength characteristics of near-infrared radiation, which is suitable for e.g. photodynamic thermotherapy of cancer.SOLUTION: A medical device (10) used for photodynamic therapy/photo-thermotherapy includes a light irradiation means (11) for irradiating an object with light of a wavelength of 810 nm. The light irradiation means includes, e.g. a light-emitting diode (13). Preferably, the medical device (10) for cancer is used to irradiate with light a diseased part administered with a liposome complex enclosing a drug for cancer treatment.

摘要翻译： 要解决的问题：提供一种利用近红外辐射的波长特性的非侵入性医疗装置，其适用于例如。 癌症的光动力学热疗。解决方案：用于光动力学治疗/光热疗法的医疗装置（10）包括用于用波长810nm的光照射物体的光照射装置（11）。 光照射装置包括，例如， 一个发光二极管（13）。 优选地，用于癌症的医疗装置（10）用于照射与包围用于癌症治疗的药物的脂质体复合体一起施用的患病部位。

公开(公告)号：JP2011109987A

公开(公告)日：2011-06-09

申请号：JP2009270830

申请日：2009-11-27

申请人： Chiba Univ ,  国立大学法人 千葉大学

发明人： OSUGA TOSHIAKI ,  SHIMIZU NAOMI ,  NAKASEKO TOMOAKI ,  TAMURA YUTAKA ,  ASAI TAKAYOSHI ,  TAKANASHI MINOKO

IPC分类号： C12N5/0789 ,  C12M3/00

摘要： PROBLEM TO BE SOLVED: To provide a cryopreservation agent evadable of the side effects of the use of DMSO as the cryopreservation agent of the blood cell.
SOLUTION: The cryopreservation agent of the blood cell contains N-methylacetamide, and dextran and/or hydroxyethyl starch. Preferably, the concentration of the N-methylacetamide in the cryopreservation agent is 3-8%, and the blood cell is hematopoietic stem cell. Further, the method of the cryopreservation of the blood cell includes freezing the blood cell with the cryopreservation agent. The cryopreservation agent is effective for the cryopreservation of the blood cell, and enables the cell to be preserved semipermanently while maintaining the proliferation potency to provide high survival rate after thawing.
COPYRIGHT: (C)2011,JPO&INPIT

摘要翻译： 待解决的问题：提供一种不能使用DMSO作为血细胞的低温保存剂的副作用的冷冻保存剂。 解决方案：血细胞的冷冻保存剂含有N-甲基乙酰胺，葡聚糖和/或羟乙基淀粉。 优选地，冷冻保存剂中N-甲基乙酰胺的浓度为3-8％，血细胞为造血干细胞。 此外，血细胞的低温保存方法包括用冷冻保存剂冷冻血细胞。 冷冻保存剂对血细胞的低温保存是有效的，并能使细胞保持半永久性，同时保持增殖效力，从而在解冻后提供高存活率。 版权所有（C）2011，JPO＆INPIT

公开(公告)号：JP2007137841A

公开(公告)日：2007-06-07

申请号：JP2005336110

申请日：2005-11-21

申请人： Chiba Univ ,  National Institute Of Advanced Industrial & Technology ,  国立大学法人 千葉大学 ,  独立行政法人産業技術総合研究所

发明人： TAKIGUCHI MASAKI ,  MACHIDA MASAYUKI ,  TAMURA YUTAKA ,  HIWASA SHIGEKI ,  SHIMOIDE MASAYOSHI

IPC分类号： A61K38/00 ,  A61P17/00 ,  A61P19/04 ,  A61P25/28 ,  A61P35/00 ,  A61P43/00 ,  C07K14/47 ,  C12N5/079 ,  C12N5/09

摘要： PROBLEM TO BE SOLVED: To obtain a new cell growth regulator comprising a peptide having a regulatory action on cell growth. SOLUTION: The human cancer cell proliferation inhibitor and the fibroblast growth promoter each comprise a peptide represented by formula Cys Pro X1 Arg Cys Gln Cys His Leu Arg Val Val Gln Cys (sequence number 1) [X1 is Phe or Tyr; first Cys and seventh Cys are bound and fifth Cys and 14th Cys are bound by a disulfide bond, respectively] or represented by formula Cys X2 X3 Pro Gly His X4 X5 X6 Lys Ala Ser Tyr Ser Gly Val Cys (sequence number 2) [X2 is Pro or Arg; X3 is Pro or Ala; X4 is Asn or Pro; X5 is Thr or Ser; X6 is Lys or Arg; first Cys and 16th Cys are bound by a disulfide bond] as an active ingredient. COPYRIGHT: (C)2007,JPO&INPIT

摘要翻译： 要解决的问题：获得包含对细胞生长具有调节作用的肽的新细胞生长调节剂。 解决方案：人类癌细胞增殖抑制剂和成纤维细胞生长促进剂各自包含由式Cys Pro X1 Arg Cys Gln Cys His Leu Arg Val Val Gln Cys（序列号1）表示的肽[X1是Phe或Tyr; 分别表示Cys和Cys与第七个Cys结合，第五个Cys和第十四个Cys分别被二硫键结合）或由式Cys X2 X3 Pro Gly His X4 X5 X6 Lys Ala Ser Tyr Ser Gly Val Cys（序列号2）[X2 是Pro或Arg; X3是Pro或Ala; X4是Asn或Pro; X5是Thr或Ser; X6为Lys或Arg; 第一个Cys和第十六个Cys被二硫键结合]作为活性成分。 版权所有（C）2007，JPO＆INPIT