-
1.
公开(公告)号:JP2014185149A
公开(公告)日:2014-10-02
申请号:JP2014046962
申请日:2014-03-10
Applicant: Decode Genetics Ehf , デコード ジェネティクス イーエイチエフ
Inventor: JASBIR SINGH , MARK E GURNEY , ALEX BURGIN , VINCENT SANDANAYAKA , ALEXANDER KISELYOV , MOTTA ADALIE , GARY SCHULTZ , GEORGETA HATEGAN , TIMOTHY HAGEN
IPC: C07C43/29 , A61K31/05 , A61K31/085 , A61K31/09 , A61K31/10 , A61K31/12 , A61K31/122 , A61K31/13 , A61K31/136 , A61K31/137 , A61K31/165 , A61K31/166 , A61K31/167 , A61K31/17 , A61K31/18 , A61K31/216 , A61K31/24 , A61K31/27 , A61K31/277 , A61K31/381 , A61K31/404 , A61K31/41 , A61K31/415 , A61K31/4192 , A61K31/426 , A61K31/437 , A61K31/44 , A61K31/4402 , A61K31/4427 , A61K31/4439 , A61K31/501 , A61K31/63 , A61K45/00 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/10 , A61P19/00 , A61P25/14 , A61P25/22 , A61P25/24 , A61P25/28 , A61P29/00 , A61P35/00 , A61P43/00 , C07C49/753 , C07C49/84 , C07C69/76 , C07C205/35 , C07C217/80 , C07C217/84 , C07C225/22 , C07C233/25 , C07C233/43 , C07C235/42 , C07C237/04 , C07C255/54 , C07C275/32 , C07C275/42 , C07C311/08 , C07C311/29 , C07C311/40 , C07C317/22 , C07C323/19 , C07C323/37 , C07D205/04 , C07D207/08 , C07D207/12 , C07D207/27 , C07D207/273 , C07D207/404 , C07D209/12 , C07D209/38 , C07D209/48 , C07D211/22 , C07D211/76 , C07D211/88 , C07D213/30 , C07D213/38 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/81 , C07D213/82 , C07D213/84 , C07D213/85 , C07D213/89 , C07D231/12 , C07D231/16 , C07D233/36 , C07D233/64 , C07D233/88 , C07D233/90 , C07D233/94 , C07D235/08 , C07D235/12 , C07D237/14 , C07D239/42 , C07D249/08 , C07D249/18 , C07D257/04 , C07D261/08 , C07D263/22 , C07D271/10 , C07D271/12 , C07D277/20 , C07D277/42 , C07D285/12 , C07D285/135 , C07D295/12 , C07D305/08 , C07D307/12 , C07D307/22 , C07D317/46 , C07D317/54 , C07D331/04 , C07D333/16 , C07D333/32 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/10 , C07D403/12 , C07D405/04 , C07D405/10 , C07D409/04 , C07D413/04 , C07D413/06 , C07D413/10 , C07D471/04 , C07D493/08
CPC classification number: C07C217/84 , A61K31/136 , A61K31/397 , A61K31/41 , A61K31/426 , A61K31/437 , A61K31/44 , A61K31/4418 , A61K31/4427 , A61K31/5377 , A61K45/06 , C07B2200/05 , C07C65/40 , C07C69/94 , C07C275/32 , C07C275/62 , C07C305/24 , C07C307/10 , C07D205/04 , C07D207/16 , C07D213/38 , C07D213/40 , C07D213/64 , C07D213/65 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/76 , C07D213/79 , C07D213/81 , C07D213/84 , C07D213/89 , C07D231/12 , C07D233/90 , C07D239/42 , C07D257/04 , C07D275/06 , C07D277/42 , C07D285/12 , C07D285/135 , C07D401/04 , C07D401/06 , C07D403/04 , C07D471/04 , C07D473/18 , C07D473/40
Abstract: PROBLEM TO BE SOLVED: To provide a biaryl phosphodiesterase-4 (PDE4) inhibitor useful for treatment and prevention of stroke, myocardial infarction, cardiovascular inflammatory diseases and central nervous system disorders.SOLUTION: There is provided a biaryl compound having at least one further ring. The specific embodiment is.
Abstract translation: 要解决的问题:提供可用于治疗和预防中风,心肌梗塞,心血管炎性疾病和中枢神经系统疾病的联芳基磷酸二酯酶-4(PDE4)抑制剂。解决方案:提供了具有至少一个另外的环的联芳基化合物 。 具体实施例是。