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1.发明专利2-SUBSTITUTION-p-QUINONE DERIVATIVE FOR TREATMENT OF OXIDATIVE STRESS DISEASE 审中-公开用于治疗氧化应激疾病的2-替代对 - 喹诺酮衍生物
公开(公告)号：JP2014098042A
公开(公告)日：2014-05-29
申请号：JP2014038420
申请日：2014-02-28
发明人： ANDREW W HIINMAN , KIERON E WESSON , ORION D JANKOWSKI , PAUL MOLLARD , WILLIAM D SHRADER , CHRISTPHER R CORNELL
IPC分类号： A61K31/164 , A61K31/17 , A61K31/18 , A61K31/381 , A61K31/445 , A61P3/10 , A61P9/00 , A61P13/02 , A61P25/00 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/28 , A61P27/02 , A61P27/16 , A61P35/00 , A61P43/00 , C07C233/31 , C07C233/76 , C07C275/12 , C07C311/03 , C07C311/16 , C07D211/44 , C07D339/04
CPC分类号： C07D295/195 , C07C45/00 , C07C45/30 , C07C205/34 , C07C233/31 , C07C233/61 , C07C233/76 , C07C235/34 , C07C235/40 , C07C235/78 , C07C255/57 , C07C255/60 , C07C275/22 , C07C275/30 , C07C311/03 , C07C311/16 , C07C311/17 , C07C311/29 , C07C2601/02 , C07C2601/14 , C07C2601/16 , C07D209/08 , C07D211/46 , C07D213/56 , C07D213/75 , C07D213/82 , C07D215/08 , C07D217/06 , C07D295/215 , C07D311/74 , C07D317/66 , C07D319/18 , C07D339/04 , C07C47/575 , C07C47/277
摘要： PROBLEM TO BE SOLVED: To provide a 2-substitution-p-quinone derivative for treatment of oxidative stress diseases.SOLUTION: A method for therapy or suppression of oxidative stress diseases including mitochondrial diseases, energy treatment reduction disorders, neurodegenerative diseases and diseases due to aging; and a compound useful in the method of the present invention, such as a 2-substitution-p-quinone derivative as disclosed in the present description are disclosed. In another embodiment, the present invention encompasses a method for therapy or suppression of oxidative stress disorders such as mitochondria disorders, energy treatment reduction disorders, neurodegeneration disorders and diseases due to aging, for regulation of one or more energy biomarkers, for normalization of one or more energy biomarkers and for enhancement of one or more energy biomarkers, by administering a therapeutically effective amount or effective amount of one or more kinds of compounds of the formula I.
摘要翻译： 要解决的问题：提供2-取代对醌衍生物用于治疗氧化应激疾病。解决方案：一种治疗或抑制氧化应激疾病的方法，包括线粒体疾病，能量治疗减少障碍，神经变性疾病和疾病，由于 老化; 并且公开了可用于本发明方法的化合物，如本说明书中公开的2-取代对 - 醌衍生物。 在另一个实施方案中，本发明包括用于治疗或抑制氧化应激障碍（例如线粒体疾病，能量治疗减少障碍，神经变性疾病和由于衰老引起的疾病），用于调节一种或多种能量生物标志物，用于一种或多种能量生物标记的归一化的方法 更多能量生物标志物和用于增强一种或多种能量生物标志物，通过施用治疗有效量或有效量的一种或多种式I化合物。
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2.发明专利4-(p-QUINOLYL)-2-HYDROXYBUTANE AMIDE DERIVATIVE FOR TREATMENT OF MITOCHONDRIAL DISEASE 审中-公开4-（对 - 喹啉）-2-羟基丁酰胺衍生物用于治疗麻醉病
公开(公告)号：JP2014098025A
公开(公告)日：2014-05-29
申请号：JP2014029395
申请日：2014-02-19
IPC分类号： C07C235/78 , A61K31/16 , A61K31/164 , A61K31/165 , A61K31/353 , A61K31/4015 , A61K31/417 , A61K31/4402 , A61K31/445 , A61K31/4453 , A61K31/495 , A61K31/5375 , A61P3/10 , A61P3/12 , A61P9/00 , A61P9/10 , A61P13/00 , A61P21/00 , A61P25/00 , A61P25/02 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , A61P27/02 , A61P35/00 , A61P43/00 , C07D207/27 , C07D211/46 , C07D213/40 , C07D233/61 , C07D295/12 , C07D295/18 , C07D311/72
CPC分类号： C07C235/80 , C07C235/78 , C07C317/28 , C07C2601/02 , C07C2601/16 , C07D207/26 , C07D207/27 , C07D211/46 , C07D213/40 , C07D213/50 , C07D233/61 , C07D265/30 , C07D295/116 , C07D295/13 , C07D295/185 , C07D295/192 , C07D311/66
摘要： PROBLEM TO BE SOLVED: To provide a 4-(p-quinolyl)-2-hydroxybutane amide derivative for a treatment of mitochondrial diseases.SOLUTION: A method of treating or suppressing mitochondrial diseases, for example Friedreich ataxia (FRDA), Leber's hereditary optic neuropathy (LHON), mitochondrial myopathy, encephalopathy, lacto acidosis and stroke (MELAS), Kearns-Sayre syndrome (KSS) is disclosed and compounds useful in the method, for example 4-(p-quinolyl)-2-hydroxybutane amide derivative are also disclosed. Methods and compounds useful for treating other disorders, for example amyotrophic lateral sclerosis (ALS), Huntington's disease, Parkinson's disease and pervasive developmental disorders, for example autism are also disclosed. An energy biomarker useful in evaluation of metabolic status of a subject and effectiveness of the treatment is also disclosed.
摘要翻译： 要解决的问题：提供用于治疗线粒体疾病的4-（对 - 喹啉基）-2-羟基丁酰胺衍生物。解决方案：治疗或抑制线粒体疾病的方法，例如弗里德里希共济失调（FRDA），莱伯氏遗传性视神经 公开了神经病变（LHON），线粒体肌病，脑病，乳酸性酸中毒和中风（MELAS），Kearns-Sayre综合征（KSS），并且该方法中有用的化合物，例如4-（对 - 喹啉基）-2-羟基丁酰胺衍生物 也披露。 还公开了可用于治疗其它病症（例如肌萎缩性侧索硬化症（ALS），亨廷顿病，帕金森病和普遍性发育障碍，例如自闭症）的方法和化合物。 还公开了可用于评估受试者的代谢状态和治疗有效性的能量生物标志物。
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