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公开(公告)号：JP2011168609A
公开(公告)日：2011-09-01
申请号：JP2011092035
申请日：2011-04-18
申请人： Novo Nordisk As , ノボ・ノルデイスク・エー/エス
发明人： POLISETTI DHARMA RAO , KODRA JANOS TIBOR , LAU JESPER , BLOCH PAW , VALCARCE-LOPEZ MARIA CARMEN , BLUME NIELS , GUZEL MUSTAFA , SANTHOSH KALPATHY CHIDAMBARESWARAN , MJALLI ADNAN M M , ANDREWS ROBERT CARL , SUBRAMANIAN GOVINDAN , ANKERSEN MICHAEL , VEDSOE PER , MURRAY ANTHONY , JEPPESEN LONE
IPC分类号： C07D213/75 , C07D277/20 , A61K31/41 , A61K31/4196 , A61K31/426 , A61K31/427 , A61K31/433 , A61K31/4402 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/52 , A61K31/5377 , A61K31/695 , A61K45/00 , A61K45/06 , A61P1/14 , A61P3/04 , A61P3/06 , A61P3/08 , A61P3/10 , A61P5/50 , A61P9/10 , A61P9/12 , A61P43/00 , C07D277/42 , C07D277/46 , C07D277/48 , C07D277/52 , C07D277/54 , C07D277/56 , C07D285/135 , C07D417/06 , C07D417/12 , C07D417/14 , C07D473/38 , C07F7/10 , C07F7/18
CPC分类号： C07D277/38 , A61K31/426 , A61K31/427 , A61K31/454 , A61K31/55 , A61K45/06 , C07D213/75 , C07D277/46 , C07D277/48 , C07D277/52 , C07D277/54 , C07D277/56 , C07D285/135 , C07D417/06 , C07D417/12 , C07D417/14 , C07D473/38
摘要： PROBLEM TO BE SOLVED: To provide compounds useful for the management, treatment, control, or adjunct treatment of diseases where increasing the activity of glucokinase is beneficial. SOLUTION: This invention relates to aryl carbonyl derivatives of general formula (I), which are activators of glucokinase, pharmaceutically acceptable salts, solvates, or prodrugs thereof. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译： 待解决的问题：提供可用于治疗，治疗，控制或辅助治疗增加葡萄糖激酶活性的疾病的化合物有益的化合物。 解决方案：本发明涉及通式（I）的芳基羰基衍生物，其是葡糖激酶的活化剂，其药学上可接受的盐，溶剂合物或前药。 版权所有（C）2011，JPO＆INPIT
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公开(公告)号：JP2010265306A
公开(公告)日：2010-11-25
申请号：JP2010162302
申请日：2010-07-16
申请人： Novo Nordisk As , ノボ・ノルデイスク・エー/エス
发明人： POLISETTI DHARMA RAO , KODRA JANOS TIBOR , LAU JESPER , BLOCH PAW , VALCARCE-LOPEZ MARIA CARMEN , BLUME NIELS , GUZEL MUSTAFA , SANTHOSH KALPATHY CHIDAMBARESWARAN , MJALLI ADNAN M M , ANDREWS ROBERT CARL , SUBRAMANIAN GOVINDAN , ANKERSEN MICHAEL , VEDSOE PER , MURRAY ANTHONY , JEPPESEN LONE
IPC分类号： C07D213/75 , C07D277/20 , A61K31/426 , A61K31/427 , A61K31/433 , A61K31/4402 , A61K31/4427 , A61K31/4439 , A61K31/444 , A61K31/4523 , A61K31/454 , A61K31/496 , A61K31/506 , A61K31/52 , A61K31/5377 , A61K31/695 , A61K45/00 , A61K45/06 , A61P1/04 , A61P1/14 , A61P3/04 , A61P3/06 , A61P3/08 , A61P3/10 , A61P5/00 , A61P5/50 , A61P9/12 , A61P43/00 , C07D277/42 , C07D277/46 , C07D277/48 , C07D277/52 , C07D277/54 , C07D277/56 , C07D285/135 , C07D417/06 , C07D417/12 , C07D417/14 , C07D473/38 , C07F7/18
CPC分类号： C07D277/38 , A61K31/426 , A61K31/427 , A61K31/454 , A61K31/55 , A61K45/06 , C07D213/75 , C07D277/46 , C07D277/48 , C07D277/52 , C07D277/54 , C07D277/56 , C07D285/135 , C07D417/06 , C07D417/12 , C07D417/14 , C07D473/38
摘要： PROBLEM TO BE SOLVED: To provide activators of glucokinase useful for the management, treatment, control, or adjuvant treatment of diseases, where increasing glucokinase activity is beneficial. SOLUTION: The aryl carbonyl derivatives represented by general formula (I), has glucokinase activating properties. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译： 要解决的问题：提供可用于治疗，治疗，控制或辅助治疗疾病的葡萄糖激酶的活化剂，其中增加葡糖激酶活性是有益的。 解决方案：由通式（I）表示的芳基羰基衍生物具有葡糖激酶活化性质。 版权所有（C）2011，JPO＆INPIT
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公开(公告)号：JP2011006435A
公开(公告)日：2011-01-13
申请号：JP2010178083
申请日：2010-08-06
发明人： LAU JESPER , KODRA JANOS TIBOR , GUZEL MUSTAFA , SANTOSH KALPATHY CHIDAMBARESWARAN , MJALLI ADNAN M M , ANDREWS ROBERT CARL , POLISETTI DHARMA RAO
IPC分类号： C07D213/75 , C07D239/42 , A61K31/16 , A61K31/18 , A61K31/426 , A61K31/427 , A61K31/433 , A61K31/4402 , A61K31/443 , A61K31/4436 , A61K31/4439 , A61K31/505 , A61K45/00 , A61K45/06 , A61P1/00 , A61P1/18 , A61P3/00 , A61P3/04 , A61P3/06 , A61P3/10 , A61P5/50 , A61P9/00 , A61P9/10 , A61P9/12 , A61P43/00 , C07D277/20 , C07D277/44 , C07D277/46 , C07D277/48 , C07D285/135 , C07D405/12 , C07D409/12 , C07D417/12
CPC分类号： C07D277/46 , A61K31/16 , A61K31/18 , A61K45/06 , C07D213/75
摘要： PROBLEM TO BE SOLVED: To provide a glucokinase activator which is useful for the management, treatment, regulation or adjunct treatment of diseases or conditions, where increasing glucokinase activity is beneficial, e.g. for diseases such as impaired glucose tolerance (IGT), syndrome X, type II diabetes, type I diabetes, dyslipidemia, hyperlipidemia, hypertension and obesity.SOLUTION: The compound is expressed by general formula (I), in which Rin the formula (I) is such as a thiazole, thiadiazole, isothiazole, pyridine and pyrimidine, etc., which may be substituted.
摘要翻译： 要解决的问题：提供可用于治疗，治疗，调节或辅助治疗疾病或病症的葡糖激酶活化剂，其中增加葡糖激酶活性是有益的，例如， 对于葡萄糖耐量异常（IGT），X综合征，II型糖尿病，I型糖尿病，血脂异常，高脂血症，高血压和肥胖等疾病。解决方案：该化合物由通式（I）表示，其中Rin为式 ）是噻唑，噻二唑，异噻唑，吡啶和嘧啶等，它们可以被取代。
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公开(公告)号：JP2011201892A
公开(公告)日：2011-10-13
申请号：JP2011103784
申请日：2011-05-06
申请人： Novo Nordisk As , ノヴォ ノルディスク アー/エス
发明人： MURRAY ANTHONY , LAU JESPER , JEPPESEN LONE , VEDSO PER , ANKERSEN MICHAEL , LUNDBECK JANE MARIE , KRISTIANSEN MARIT , VALCARCE-LOPEZ MARIA CARMEN , POLISETTI DHARMA RAO , SUBRAMANIAN GOVINDAN , ANDREWS ROBERT CARL , CHRISTEN DANIEL P , COOPER JEREMY T , SANTHOSH KALPATHY CHIDAMBARESWARAN
IPC分类号： C07D417/12 , A61K31/4168 , A61K31/427 , A61K31/433 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/55 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/12 , A61P43/00 , C07D213/75 , C07D233/88 , C07D241/20 , C07D261/14 , C07D271/08 , C07D277/46 , C07D277/48 , C07D277/56 , C07D277/60 , C07D277/82 , C07D285/08 , C07D285/12 , C07D285/135 , C07D417/04 , C07D417/06 , C07D417/14 , C07D513/04
CPC分类号： C07D417/12 , A61K31/4168 , A61K31/427 , A61K31/433 , C07D213/75 , C07D233/88 , C07D241/20 , C07D261/14 , C07D271/08 , C07D277/48 , C07D277/56 , C07D277/60 , C07D277/82 , C07D285/08 , C07D285/135 , C07D417/04 , C07D417/06 , C07D417/14 , C07D513/04
摘要： PROBLEM TO BE SOLVED: To provide a compound as a glucokinase activator that may be useful for the management, treatment, control or adjunct treatment of diseases where increasing glucokinase activity is beneficial.SOLUTION: The compound is represented by general formula (I), being e.g. a heteroaryl-urea compound such as 1-(1-butyryl-piperidin-4-yl)-3-(5-chloro-thiazol-2-yl)-1-cyclohexylurea.
摘要翻译： 要解决的问题：提供可用于治疗，治疗，控制或辅助治疗增加葡萄糖激酶活性的疾病的化合物作为葡糖激酶活化剂。解决方案：该化合物由通式（I）表示，为 例如 诸如1-（1-丁酰基 - 哌啶-4-基）-3-（5-氯 - 噻唑-2-基）-1-环己基脲的杂芳基脲化合物。
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