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公开(公告)号：JP2011168609A
公开(公告)日：2011-09-01
申请号：JP2011092035
申请日：2011-04-18
申请人： Novo Nordisk As , ノボ・ノルデイスク・エー/エス
发明人： POLISETTI DHARMA RAO , KODRA JANOS TIBOR , LAU JESPER , BLOCH PAW , VALCARCE-LOPEZ MARIA CARMEN , BLUME NIELS , GUZEL MUSTAFA , SANTHOSH KALPATHY CHIDAMBARESWARAN , MJALLI ADNAN M M , ANDREWS ROBERT CARL , SUBRAMANIAN GOVINDAN , ANKERSEN MICHAEL , VEDSOE PER , MURRAY ANTHONY , JEPPESEN LONE
IPC分类号： C07D213/75 , C07D277/20 , A61K31/41 , A61K31/4196 , A61K31/426 , A61K31/427 , A61K31/433 , A61K31/4402 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/52 , A61K31/5377 , A61K31/695 , A61K45/00 , A61K45/06 , A61P1/14 , A61P3/04 , A61P3/06 , A61P3/08 , A61P3/10 , A61P5/50 , A61P9/10 , A61P9/12 , A61P43/00 , C07D277/42 , C07D277/46 , C07D277/48 , C07D277/52 , C07D277/54 , C07D277/56 , C07D285/135 , C07D417/06 , C07D417/12 , C07D417/14 , C07D473/38 , C07F7/10 , C07F7/18
CPC分类号： C07D277/38 , A61K31/426 , A61K31/427 , A61K31/454 , A61K31/55 , A61K45/06 , C07D213/75 , C07D277/46 , C07D277/48 , C07D277/52 , C07D277/54 , C07D277/56 , C07D285/135 , C07D417/06 , C07D417/12 , C07D417/14 , C07D473/38
摘要： PROBLEM TO BE SOLVED: To provide compounds useful for the management, treatment, control, or adjunct treatment of diseases where increasing the activity of glucokinase is beneficial. SOLUTION: This invention relates to aryl carbonyl derivatives of general formula (I), which are activators of glucokinase, pharmaceutically acceptable salts, solvates, or prodrugs thereof. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译： 待解决的问题：提供可用于治疗，治疗，控制或辅助治疗增加葡萄糖激酶活性的疾病的化合物有益的化合物。 解决方案：本发明涉及通式（I）的芳基羰基衍生物，其是葡糖激酶的活化剂，其药学上可接受的盐，溶剂合物或前药。 版权所有（C）2011，JPO＆INPIT
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公开(公告)号：JP2010265306A
公开(公告)日：2010-11-25
申请号：JP2010162302
申请日：2010-07-16
申请人： Novo Nordisk As , ノボ・ノルデイスク・エー/エス
发明人： POLISETTI DHARMA RAO , KODRA JANOS TIBOR , LAU JESPER , BLOCH PAW , VALCARCE-LOPEZ MARIA CARMEN , BLUME NIELS , GUZEL MUSTAFA , SANTHOSH KALPATHY CHIDAMBARESWARAN , MJALLI ADNAN M M , ANDREWS ROBERT CARL , SUBRAMANIAN GOVINDAN , ANKERSEN MICHAEL , VEDSOE PER , MURRAY ANTHONY , JEPPESEN LONE
IPC分类号： C07D213/75 , C07D277/20 , A61K31/426 , A61K31/427 , A61K31/433 , A61K31/4402 , A61K31/4427 , A61K31/4439 , A61K31/444 , A61K31/4523 , A61K31/454 , A61K31/496 , A61K31/506 , A61K31/52 , A61K31/5377 , A61K31/695 , A61K45/00 , A61K45/06 , A61P1/04 , A61P1/14 , A61P3/04 , A61P3/06 , A61P3/08 , A61P3/10 , A61P5/00 , A61P5/50 , A61P9/12 , A61P43/00 , C07D277/42 , C07D277/46 , C07D277/48 , C07D277/52 , C07D277/54 , C07D277/56 , C07D285/135 , C07D417/06 , C07D417/12 , C07D417/14 , C07D473/38 , C07F7/18
CPC分类号： C07D277/38 , A61K31/426 , A61K31/427 , A61K31/454 , A61K31/55 , A61K45/06 , C07D213/75 , C07D277/46 , C07D277/48 , C07D277/52 , C07D277/54 , C07D277/56 , C07D285/135 , C07D417/06 , C07D417/12 , C07D417/14 , C07D473/38
摘要： PROBLEM TO BE SOLVED: To provide activators of glucokinase useful for the management, treatment, control, or adjuvant treatment of diseases, where increasing glucokinase activity is beneficial. SOLUTION: The aryl carbonyl derivatives represented by general formula (I), has glucokinase activating properties. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译： 要解决的问题：提供可用于治疗，治疗，控制或辅助治疗疾病的葡萄糖激酶的活化剂，其中增加葡糖激酶活性是有益的。 解决方案：由通式（I）表示的芳基羰基衍生物具有葡糖激酶活化性质。 版权所有（C）2011，JPO＆INPIT
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公开(公告)号：JP2013063984A
公开(公告)日：2013-04-11
申请号：JP2012242654
申请日：2012-11-02
申请人： Novo Nordisk As , ノヴォ ノルディスク アー/エス
发明人： LAU JESPER , DOERWALD FLORENCIO ZARAGOZA , STEPHENSEN HENRIK , BLOCH PAW , HANSEN THOMAS KRUSE , MADSEN KJELD
IPC分类号： C07K14/605 , A61K38/26 , A61P1/04 , A61P1/14 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/00 , A61P9/10 , A61P9/12 , A61P25/08 , A61P25/28 , A61P43/00
CPC分类号： C07K14/605 , A61K38/00
摘要： PROBLEM TO BE SOLVED: To provide extending glucagon-like peptide 1 (GLP-1) compounds which increase the time of action in a patient as a therapeutic peptide.SOLUTION: A GLP-1 analog has a modification of at least one non-proteogenic amino acid residue in positions 7 and/or 8 relative to the sequence GLP-1(7-37), in which a lysine residue in position 26 is acylated with a moiety comprising at least two acidic groups, wherein one acidic group is bonded terminally.
摘要翻译： 待解决的问题：提供增加作为治疗性肽的患者中作用时间的胰高血糖素样肽1（GLP-1）化合物。 解决方案：GLP-1类似物相对于序列GLP-1（7-37）在位置7和/或8处具有至少一个非蛋白原性氨基酸残基的修饰，其中赖氨酸残基在位置 26被包含至少两个酸性基团的部分酰化，其中一个酸性基团末端键合。 版权所有（C）2013，JPO＆INPIT
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公开(公告)号：JP2010116407A
公开(公告)日：2010-05-27
申请号：JP2010009025
申请日：2010-01-19
发明人： LAU JESPER , DOERWALD FLORENCIO ZARAGOZA , STEPHENSEN HENRIK , BLOCH PAW , HANSEN THOMAS KRUSE , MADSEN KJELD
IPC分类号： C07K14/605 , A61K38/26 , A61P1/04 , A61P1/14 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/00 , A61P9/10 , A61P9/12 , A61P25/08 , A61P25/28 , A61P43/00
CPC分类号： C07K14/605 , A61K38/00
摘要： PROBLEM TO BE SOLVED: To provide a method which increases action time in the treating of hyperglycemia and diabetes. SOLUTION: In a glucagon like peptide (GLP-1), a GLP-1 analogue which has the remodeling of at least one nonprotein original property amino acid residue, and is the GLP-1 analogue in which a specific lysine residue is acylated by a moiety containing at least two acid groups, and one acid group combines with a terminal. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译： 待解决的问题：提供一种增加治疗高血糖和糖尿病的作用时间的方法。 解决方案：在胰高血糖素样肽（GLP-1）中，具有至少一种非蛋白原始性质氨基酸残基重构的GLP-1类似物，其中特定赖氨酸残基为 由含有至少两个酸基的部分酰化，一个酸基与末端结合。 版权所有（C）2010，JPO＆INPIT
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