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公开(公告)号：JPH06228115A
公开(公告)日：1994-08-16
申请号：JP27657793
申请日：1993-11-05
申请人： SCHERING AG
IPC分类号： C07D257/02 , C07F5/00
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公开(公告)号：JPH05214096A
公开(公告)日：1993-08-24
申请号：JP11463692
申请日：1992-05-07
申请人： SCHERING AG
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公开(公告)号：JPH03215457A
公开(公告)日：1991-09-20
申请号：JP17037290
申请日：1990-06-29
申请人： SCHERING AG
发明人： HERIBERUTO SHIYUMITSUTOOBUIRIT , YOHANESU PURATSUEKU , HAINTSU GURIISU , KABURIERE SHIYUUMANNGIAMUPIIRI , FUUBERUTO FUOOKURAA , HANSUUYOAHIMU BUAINMAN
IPC分类号： A61K49/00 , A61K49/04 , A61K49/06 , C07C227/18 , C07C229/16 , C07C229/76 , C07F5/00 , C07F9/94 , C07F15/02
摘要： Compounds of the general formula in which Z and Z each represent a hydrogen atom or the radical -(CH2)m-(C6H4)q-(O)k-(CH2)n(C6H4) l-(O)r-R, in which m and n denote the figures 0 - 20, k, l, q and r denote the figures 0 and 1 and R denotes a hydrogen atom, an unsubstituted or OR -substituted C1-C6-alkyl radical or a CH2COOR group where R denotes a hydrogen atom, a C1-C6-alkyl radical or a benzyl group, X represents a hydrogen atom and/or a metal ion equivalent of an element of atomic number 21 - 29, 42, 44 or 57 - 83, with the proviso that at least two of the substituents X represent a metal ion equivalent in which one of the substituents Z and Z represents a hydrogen atom and the other does not represent a hydrogen atom, in which - if n and l each represent the figure 0 - k and r do not simultaneously each denote the figure 1, in which Z or Z do not represent -CH2-C6H4-O-CH2-COOCH2C6H5 or CH2-C6H4-O-(CH2)5-COOCH2C6H5 and in which -(O)r-R does not represent -OH, and their salts with inorganic and/or organic bases, amino acids or amino acid amides, are useful pharmaceutical agents.
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公开(公告)号：JPH04288063A
公开(公告)日：1992-10-13
申请号：JP31854891
申请日：1991-11-07
申请人： SCHERING AG
发明人： YOHANESU PURATSUEKU , HAINTSU GURIISU , HANSUUYOAHIMU BUAINMAN , BUORUFUURIYUUDEIGAA PURESU , FUUBERUTO FUOKURAA
IPC分类号： A61K49/00 , A61K31/395 , A61K49/04 , A61K51/00 , C07D257/02 , C07D303/27
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公开(公告)号：JPH03246234A
公开(公告)日：1991-11-01
申请号：JP31444090
申请日：1990-11-21
申请人： SCHERING AG
发明人： YOHANESU PURATSUEKU , HERIBERUTO SHIYUMITSUTOOBUIRIH , HAINTSU GURIISU , GABURIERE SHIYUUMANNGIANPIIRI , FUUBERUTO FUOOKURAA , HANSUUYOAHIMU BUAINMAN , HANSU BAUAA
IPC分类号： A61B5/055 , A61K49/00 , A61K49/06 , A61K49/08 , A61K49/12 , A61K51/00 , A61K51/06 , C07F5/00 , C07G99/00 , C08G69/48 , C08G73/00 , C08G73/02 , C08G83/00 , C08G85/00 , C09K3/00
摘要： PURPOSE: To obtain a complex, comprising a nitrogen-containing cascade polymer having a complexing ligand and ions, etc., of specific elements and suitable for producing an NMR diagnostic agent and an X-ray diagnostic agent. CONSTITUTION: This cascade polymer comprises a complexing ligand, as necessary, at least 5 ions of an element of atomic numbers of 21-29, 39, 42, 44 or 57-83 and, as necessary, a cation of an inorganic and/or an organic base, an amino acid or an amino acid amide and is represented by formula I [A is an N-containing cascade nucleus of a basis multiplicity (b); S is a repeating unit; Z and Z are each represented by formula II for the first to the penultimate generation; Z is H, carboxyl, sulfo group, OH, a residue, etc., of a chelating agent or a complex K for the last generation; 96-100% of the total Z content is the residue of K; 4-0% thereof is V' (V' is one functional group or a residue V, capable of bonding through the functional group and having a bio- or a macromolecule; V is a substitutable alkylene); (b) is 1-50; (s) is 1-3].
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公开(公告)号：JPH02104588A
公开(公告)日：1990-04-17
申请号：JP18619089
申请日：1989-07-20
申请人： SCHERING AG
发明人： YOHANESU PURATSUEKU , BERUNTO RAADEYUHIERU , HAINTSU GURIISU , HANSUUYOAHIMU BUAINMAN , URURIHI SUPETSUKU
IPC分类号： A61K49/00 , A61K49/04 , A61K49/06 , A61K51/00 , C07D255/04 , C07D471/08 , C07D487/08 , C07D498/08 , C07D513/08 , C07D519/00 , C07D521/00 , C07F5/00 , C07F13/00 , C07F15/00
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