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公开(公告)号:JP5054877B2
公开(公告)日:2012-10-24
申请号:JP2002510461
申请日:2001-06-13
申请人: イミュファルマ・フランス・エスアーImmuPharma France SA , サントル・ナショナル・ドゥ・ラ・ルシェルシュ・シャンティフィクCentre National De La Recherche Scientifique
发明人: ギシャール,ジル , シャフナー,アルノー−ピエール , スムティ,ヴァンサン , ブリアン,ジャン−ポール , プロー,セルジュ , ロドリゲス,マール
IPC分类号: C07D255/02 , A61P37/02 , C07D239/10 , C07D243/04 , C07D255/04 , C07D259/00 , C07D487/04 , C07D487/14 , C07D487/22
CPC分类号: C07D239/10 , C07D243/04 , C07D255/02 , C07D255/04 , C07D259/00 , C07D487/04 , C07D487/14 , Y02P20/55
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公开(公告)号:JP2010502726A
公开(公告)日:2010-01-28
申请号:JP2009527526
申请日:2007-09-05
申请人: エモリー・ユニバーシティ
发明人: ダニエル カルマン,
IPC分类号: A61K31/505 , A61K31/167 , A61K31/277 , A61K31/341 , A61K31/352 , A61K31/357 , A61K31/381 , A61K31/395 , A61K31/405 , A61K31/4178 , A61K31/427 , A61K31/437 , A61K31/444 , A61K31/4523 , A61K31/472 , A61K31/496 , A61K31/498 , A61K31/4985 , A61K31/50 , A61K31/5025 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/522 , A61K31/5377 , A61K31/538 , A61P31/04 , A61P31/14 , A61P31/16 , A61P31/20 , A61P31/22 , A61P43/00 , C07D209/18 , C07D213/64 , C07D217/24 , C07D233/64 , C07D237/12 , C07D239/42 , C07D239/94 , C07D255/04 , C07D295/14 , C07D307/58 , C07D311/58 , C07D333/24 , C07D333/60 , C07D401/04 , C07D401/14 , C07D403/04 , C07D407/12 , C07D417/06 , C07D471/04 , C07D473/00 , C07D487/04 , C07D493/04 , C07D493/14 , C07D493/22
CPC分类号: A61K31/505 , A61K31/496 , A61K31/506 , A61K31/5377
摘要: 本発明は、病原性感染を予防及び/又は治療するための組成物及びその使用方法を提供する。 特に、本発明は、病原性感染と関連する又は病原性感染を引き起こす病原体−宿主細胞相互作用に関与するキナーゼを阻害し、したがって効果的に病原性感染を予防及び/又は治療し、従来の抗生物質及び抗ウイルス薬と比較して耐性を生じさせる可能性が遥かに少ないキナーゼ阻害剤の使用を提供する。 本発明は、急性病原性感染の治療のためのキナーゼ阻害剤の短期間の使用をさらに提供し、これらのキナーゼ阻害剤の長期間使用により引き起こされ得る毒性を回避する。
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公开(公告)号:JP3935071B2
公开(公告)日:2007-06-20
申请号:JP2002505374
申请日:2001-06-21
发明人: メアリー アッシュワース,ドリーン , マーティン イェー,クリストファー , ポール ジェンキンス,デイビッド , センプル,グリーム , ハドソン,ピーター , ロバート ウィリアム ピット,ゲイリー , ジェレミー フランクリン,リチャード
IPC分类号: C07D223/16 , A61K31/55 , A61K31/551 , A61K31/5513 , A61K31/5517 , A61K31/553 , A61K31/554 , A61P13/00 , A61P13/02 , A61P25/00 , A61P43/00 , C07D243/12 , C07D243/14 , C07D255/04 , C07D267/14 , C07D281/10 , C07D401/06 , C07D401/12 , C07D403/12 , C07D413/12 , C07D471/04 , C07D487/04 , C07D495/04 , C07D498/04 , C07D519/00
CPC分类号: C07D223/16 , C07D243/12 , C07D267/14 , C07D281/10 , C07D401/06 , C07D401/12 , C07D403/12 , C07D413/12 , C07D471/04 , C07D487/04 , C07D495/04
摘要: Compounds according to general formulae (1 and 2), wherein G 1 is an azepine derivative and G 2 is a group according to general formulae (9-11) are new. Compounds according to the invention are vasopressin V 2 receptor agonists. Pharmaceutical compositions of the compounds are useful as antidiuretic agents
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公开(公告)号:JP3492724B2
公开(公告)日:2004-02-03
申请号:JP18731993
申请日:1993-06-30
申请人: ケミプロ化成株式会社
发明人: 吉則 大前
IPC分类号: C07D255/04 , C07D249/20 , C08K5/3472 , C08K5/3475 , C08L101/00 , C09K3/00
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公开(公告)号:JP2877844B2
公开(公告)日:1999-04-05
申请号:JP18619089
申请日:1989-07-20
申请人: SHEERINGU AG
发明人: YOHANESU PURATSUEKU , BERUNTO RAADEYUHIERU , HAINTSU GURIISU , HANSUUYOAHIMU UAINMAN , URURIHI SUPETSUKU
IPC分类号: A61K49/00 , A61K49/04 , A61K49/06 , A61K51/00 , C07D255/04 , C07D471/08 , C07D487/08 , C07D498/08 , C07D513/08 , C07D519/00 , C07D521/00 , C07F5/00 , C07F13/00 , C07F15/00
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公开(公告)号:JPH07196904A
公开(公告)日:1995-08-01
申请号:JP33759893
申请日:1993-12-28
发明人: OOASHI KAZUHIRO , NAGANORI YUKIE , NISHIHATA TORU
IPC分类号: C07D249/06 , C07D255/04 , C08K5/00 , C08K5/15 , C08K5/1545 , C08K5/16 , C08K5/3432 , C08K5/3467 , C08K5/3477 , C08L69/00 , C09K3/00
摘要: PURPOSE:To obtain a polycarbonate resin composition useful for a building material, etc., having sufficient weather resistance by mixing a polycarbonate resin with a benzotriazole compound as an ultraviolet absorber and a coumarin compound or a naphthalimide compound as a fluorescent blightener. CONSTITUTION:(A) 100 pts.wt. of a polycarbonate resin is mixed with (B) 5-25 pts.wt. of a benzotriazole compound of formula I (R1 is an alkyl, nitro or an alkoxyl (s) is 1-4; Z is a halogen or an alkyl) or formula II (t is 1-3) [e.g. 2(2'- hydroxy-5'-methylphenyl)benzotriazole, etc.) as an ultraviolet absorber and (C) 0.1-10 pts.wt. of one or more a coumarin compound of formula III [R2 is amino (derivative) or OH; R3 and R4 are H, an alkyl or phenyl) (e.g. 3-phenyl-7-amino- coumarin) and a naphthalimide compound of formula IV (R5 and R6 are H or an alkoxy; R7 is H or an alkyl) (e.g. 4-methoxy-N-methylnaphthalimide) as a fluorescent blightener to give the objective resin composition.
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公开(公告)号:JPH02104588A
公开(公告)日:1990-04-17
申请号:JP18619089
申请日:1989-07-20
申请人: SCHERING AG
发明人: YOHANESU PURATSUEKU , BERUNTO RAADEYUHIERU , HAINTSU GURIISU , HANSUUYOAHIMU BUAINMAN , URURIHI SUPETSUKU
IPC分类号: A61K49/00 , A61K49/04 , A61K49/06 , A61K51/00 , C07D255/04 , C07D471/08 , C07D487/08 , C07D498/08 , C07D513/08 , C07D519/00 , C07D521/00 , C07F5/00 , C07F13/00 , C07F15/00
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公开(公告)号:JPH0247651A
公开(公告)日:1990-02-16
申请号:JP16553889
申请日:1989-06-29
申请人: EASTMAN KODAK CO
IPC分类号: C07D255/04 , C07D257/04 , C07D401/12 , C07D403/06 , C07D403/12 , G03C7/305
摘要: PURPOSE: To enable a photograplxically useful group to be released and to enhance image acutance by incorporating a compound having a specified coupling-off group at a coupling site. CONSTITUTION: The photographic sensitive material contains the coupling-off group to be allowed to release the photographically useful group by an intramolecular nucleophilic substitution reaction at the coupling site, preferably, containing a coupler and this coupling-off group is represented by formula I in which Q is an N atom or a C-R1 group; R1 is an H atom or a 1-20 C straight or branched alkyl group, such as a methyl, ethyl, or propyl group or an aryl group, such as a phenyl or chlorophenyl group; PUG is the photographically useful group; and Z is an atomic group necessary to complete a nonaromatic hetero ring, such as a 4-, 5-, or 6-membered hetero ring or the like, thus permitting not only the photographically useful group to be released but also the acutance of an image formed by processing the photographic material to be enhanced.
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公开(公告)号:JPS6383077A
公开(公告)日:1988-04-13
申请号:JP22748586
申请日:1986-09-26
申请人: RIKAGAKU KENKYUSHO
发明人: IWATA MASAAKI , KUZUHARA HIROMI
IPC分类号: C07D255/04 , C07D257/10 , C07D259/00 , C07D491/18
摘要: NEW MATERIAL:A compound expressed by formula I [Ts is tolenesulfonyl; n is 1-3; A is formula II or formula III (R is H or lower alkyl)]. EXAMPLE:N ,N ,N -Tritosyl-14-hydroxymethyl-14,15'-O-isopropylide ne-11-methyl -2,5,8-triaza[9](2,5)-pyridinophane. USE:Useful for synthesis of simpler functional molecule having both function of enzyme and coenzyme-B6. A molecule keeping restricted rotation, containing a coordination group sufficient to take in other guest molecule therein and having a functional group capable of expressing a catalytic action of coenzyme- B6 is available. PREPARATION:A compound expressed by formula IV is reacted with a compound expressed by formula V (X is halogen) in a polar solvent such as dimethylformamide, etc., in the presence of a dehydrohalogenating agent such as anhydrous K2CO3, etc., at room temperature-100 deg.C for 2-24hr to provide a compound expressed by formula I in high yield.
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公开(公告)号:JPS5782379A
公开(公告)日:1982-05-22
申请号:JP15996480
申请日:1980-11-13
申请人: Toray Ind Inc
发明人: SATOU HARUYO , IMAMURA SHINZOU
IPC分类号: C07D255/04
摘要: NEW MATERIAL:The compound of formula I.
USE: Intermediate of pharmaceuticals.
PROCESS: The compound of formula I can be prepared by reacting α-aminocyclohexanone oxide with the imino ether hydrochloride of formula II (R and R' are lower alkyl) in acetic acid at 40W70°C.
COPYRIGHT: (C)1982,JPO&Japio摘要翻译: 新材料:式Ⅰ化合物。用途:药物中间体。 方法:式I化合物可以通过使α-氨基环己酮氧化物与式II的亚氨基醚盐酸盐(R和R'是低级烷基)在乙酸中在40-70℃反应来制备。
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