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公开(公告)号：JP2007314576A
公开(公告)日：2007-12-06
申请号：JP2007219918
申请日：2007-08-27
发明人： CURRAN DENNIS P , HADIDA RUAH SABINE , HASHINO MASAHIDE , STUDER ARMIDO , WIPF PETER , JEGER PATRICK , KIM SUN-YOUNG , FERRITTO RAFAEL
IPC分类号： C07C1/26 , C07D261/08 , C07B39/00 , C07B47/00 , C07B61/00 , C07B63/00 , C07B63/02 , C07C1/28 , C07C13/10 , C07C13/28 , C07C13/615 , C07C17/395 , C07C23/38 , C07C29/14 , C07C33/20 , C07C33/22 , C07C45/68 , C07C49/04 , C07C49/105 , C07C49/323 , C07C67/343 , C07C69/24 , C07C69/608 , C07C201/12 , C07C205/06 , C07C205/19 , C07C231/02 , C07C231/06 , C07C231/10 , C07C233/81 , C07C237/04 , C07C237/06 , C07C237/22 , C07C237/24 , C07C237/42 , C07C253/30 , C07C255/03 , C07C255/31 , C07C255/46 , C07C255/47 , C07D239/36 , C07D257/04 , C07D261/04 , C07F7/08 , C07F7/12 , C07F7/18 , C07F7/22 , C07F7/30
CPC分类号： C07F7/2284 , C07B61/00 , C07B63/02 , C07C201/12 , C07C231/10 , C07C2601/14 , C07F7/0812 , C07F7/0818 , C07F7/12 , C07F7/123 , C07F7/1844 , C07F7/188 , C07F7/2212 , C07F7/2216 , C07F7/222 , C40B40/04 , C40B50/00 , C40B99/00 , Y02P20/582 , C07C237/22 , C07C205/06 , C07C205/22
摘要： PROBLEM TO BE SOLVED: To provide a method for synthesizing an objective organic molecule by using an organic/fluorous phase separation technique. SOLUTION: The synthesizing method comprises the steps of: (a) reacting a first organic compound with a first fluorination-reaction component, and bonding a fluorous group to the first organic compound to obtain a second fluorination-reaction component; (b) reacting the second fluorination-reaction component in a reaction scheme to obtain an objective fluorine-containing product; (c) separating the objective product from entire second organic compound/organic byproducts; and (d) reacting the fluorine-containing product and cleaving the fluorous group to obtain the objective organic product. Here, the fluorous group contains fluorine sufficient to form the fluorine-containing objective product from the second fluorination-reaction component in the reaction scheme, and the scheme has at least one reaction with at least the second organic compound separable from entire surplus second organic compound and the whole organic byproducts generated in the scheme by the organic/fluorous phase separation technique. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译： 待解决的问题：提供通过使用有机/氟相分离技术合成目标有机分子的方法。 解决方案：合成方法包括以下步骤：（a）使第一有机化合物与第一氟化反应组分反应，并将氟基与第一有机化合物结合，得到第二氟化反应组分; （b）使反应方案中的第二氟化反应组分反应得到目标含氟产物; （c）将目标产物与全部第二有机化合物/有机副产物分离; 和（d）使含氟产物反应并裂解氟团以获得目标有机产物。 这里，含氟基团含有足以在反应方案中由第二氟化反应组分形成含氟目标产物的氟，并且该方案与至少与第二有机化合物分离的至少一种反应至少可以与剩余的第二有机化合物分离 和通过有机/氟相分离技术在方案中产生的整个有机副产物。 版权所有（C）2008，JPO＆INPIT
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