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    Tocopherol and preparation of particularly d-alpha- tocopherol, intermediate product of said method and application thereof
    4.
    发明专利
    Tocopherol and preparation of particularly d-alpha- tocopherol, intermediate product of said method and application thereof 失效
    特异性和制备特异性D-ALPHA-TOCOPHEROL的方法及其应用的中间产物

    公开(公告)号：JPS591476A

    公开(公告)日：1984-01-06

    申请号：JP10156983

    申请日：1983-06-07

    申请人： Eisai Co Ltd

    发明人： KAARU HAINTSU DEETSU

    IPC分类号： C07C29/132 ,  C07C43/23 ,  C07D303/04 ,  C07D311/72 ,  C07F11/00

    CPC分类号： C07D303/04 ,  C07C29/132 ,  C07C43/23 ,  C07D311/72 ,  C07F11/00 ,  C07C33/042 ,  C07C33/048

    摘要： PURPOSE: To obtain the titled substance, by separating a metallic carbonyl part from a reaction product of a carbonyl-alkenylcarbenemetallic complex with an alkynol, removing the ether from the metallic carbonyl part, and cyclizing the resultant product in the presence of an acidic catalyst.
    CONSTITUTION: A carbonyl-alkenylcarbene-metallic complex having substitutent groups R
    1 and R
    2 linked to the alkenyl group and an ether type substituent group R
    3 [R
    1 is CH
    3 or OCH
    3 ; R
    2 is H, CH
    3 or OCH
    3 ; R
    3 is CH
    3 , C
    2 H
    5 , COR or SiR
    3 (R is alkyl, aryl or alkylaryl)], e.g. the compound of formula I , is reacted with a compound of formula II (R
    4 is H or CH
    3 ; R
    5 is [(CH
    2 )
    3 CHCH
    3 ]
    3 CH
    3 , etc.), to give a compound of formula III, and the metallic carbonyl part is then separated therefrom to afford a compound of formula IV, etc. The resultant compound of formula IV is then subjected to the removal of the ether and then cyclized in the presence of an acidic catalyst to give the titled substance (natural vitamine E). The compounds of formulas III and IV are novel substances.
    COPYRIGHT: (C)1984,JPO&Japio

    摘要翻译： 目的：为了获得标题物质，通过将羰基 - 链烯基碳金属络合物与炔醇的反应产物中的金属羰基部分分离，从金属羰基部分除去乙醚，并在酸性催化剂存在下环化所得产物。 构成：具有与链烯基连接的取代基R1和R2的羰基 - 烯基碳烯金属络合物和醚型取代基R 3 [R 1是CH 3或OCH 3; R2是H，CH3或OCH3; R3是CH3，C2H5，COR或SiR3（R是烷基，芳基或烷基芳基）]，例如 将式I化合物与式II化合物（R4是H或CH3; R5是[（CH2）3CHCH3] 3CH3等）反应，得到式III化合物，然后将金属羰基部分 从而得到式IV化合物等。然后将所得到的式IV化合物除去醚，然后在酸性催化剂存在下环化，得到标题物质（天然维生素E）。 式III和IV的化合物是新物质。