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    CYCLIC AMINE-SUBSTITUTED ALKYL KETONE AND ITS PRODUCTION
    1.
    发明专利
    CYCLIC AMINE-SUBSTITUTED ALKYL KETONE AND ITS PRODUCTION 失效

    公开(公告)号：JPH1087643A

    公开(公告)日：1998-04-07

    申请号：JP12794597

    申请日：1997-05-01

    Applicant: CIBA GEIGY AG

    Inventor： HUESLER RINALDO ,  SCHWABE RUDOLF ,  LUISOLI RETO

    IPC: C07D295/10 ,  C07D211/14 ,  C07D241/04 ,  C07D265/28 ,  C07D265/30 ,  C07D295/112 ,  C07D295/12 ,  C07D295/135 ,  C08F2/50 ,  G03F7/028 ,  G03F7/031

    Abstract: PROBLEM TO BE SOLVED: To obtain a new compound substituted with a cyclic amine at a para position and useful as an intermediate for synthesizing a photoinitiator for photopolymerization of an ethylenically unsaturated compound. SOLUTION: This new compound is a compound of formula I (R and R together become O, S, or a 3-20C alkylene, which may be discontinued by N(R4 ); R3 is a 2-20C alkyl; R4 is H, a 1-3C alkyl, a 3-5C alkenyl, phenyl, etc.; etc.), e.g. 1-(4-morpholinophenyl)butan-1-one. A compound of formula I is obtained by subjecting a p-halophenyl alkyl ketone of formula II (X is a halogen) to aminolysis using a cyclic amine of formula III in water at a temperature of at least 130 deg.C. The compound of formula III is used in an amount of 2.5-12mol equivalent and further water is used in an amount of 1-100mol equivalent, each based on the compound of formula II. Examples of a compound of formula II include 1-(4-bromophenyl)butan-1-one, and examples of a cyclic amine of formula III include morpholine.

    NOVEL FORTIMICIN COMPOUND AND ITS PREPARATION
    7.
    发明专利
    NOVEL FORTIMICIN COMPOUND AND ITS PREPARATION 失效

    公开(公告)号：JPS55162790A

    公开(公告)日：1980-12-18

    申请号：JP4112380

    申请日：1980-03-28

    Applicant: KYOWA HAKKO KOGYO KK

    Inventor： ARUMA UITSUTOMAN GOORUDOSUTAIN ,  AARU ERUMAA KURARENSU FUAAGAA

    IPC: C07D498/08 ,  A61K31/535 ,  A61P31/04 ,  C07D265/28 ,  C07H15/224 ,  C12P17/18 ,  C12P19/48 ,  C12R1/29

    Abstract: PURPOSE:A fortimicin compound of the formula (R1 and R2 are H or methylamino groups; R3 and R4 are H or methoxy groups; R2 and R4 are H and R3 is methoxy group when R1 is methylamino group; R1 and R3 are H and R4 is methoxy group when R2 is methylamino group), and its salt. EXAMPLE:Fortimicin AH. USE:An antimicrobial and an intermediate for the preparation of 4-N-fortimicins AH and AI useful as an antibiotic against sensitive Gram-positive and Gram-negative bacteria. PROCESS:A microorganism, e.g. Micromonospora olivoasterospora ATCC21819 (FERM-P No.1560), which belongs to the genus Micromonospora, and has the ability to produce fortimicins AH and AI, is incubated in a culture medium at 25- -40 deg.C and a neutral pH by the submerged spinner culture method to produce and accumulate antibiotic fortimicins AH and AI, which are isolated and recovered from the culture to give the compound of the formula.

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