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    PRODUCTION OF CEPHEM COMPOUND
    3.
    发明专利
    PRODUCTION OF CEPHEM COMPOUND 失效

    公开(公告)号：JP2001072686A

    公开(公告)日：2001-03-21

    申请号：JP24727299

    申请日：1999-09-01

    申请人： OTSUKA CHEMICAL CO LTD

    发明人： TANAKA HIDEO ,  KAMEYAMA YUTAKA

    IPC分类号： B01J31/30 ,  C07B61/00 ,  C07D501/00 ,  C07D501/04 ,  C07D501/16 ,  C07D501/22 ,  C07D501/24

    摘要： PROBLEM TO BE SOLVED: To selectively obtain an alkenylcephem compound or a norcephem compound by acting an alkenyl halide, a nickel catalyst, a specific metal and a specific metal compound to a specific 3-cephem compound in a solvent. SOLUTION: 3-Alkenylcephem compound or 3-norcephem compound expressed by formula II [R1 is H, a halogen or a (protected) amino; R2 is H, a halogen, a lower alkoxy, a lower acyl or the like; R3 is H or a carboxylic acid protecting group; R5 is H or a (substituted) 1-alkenyl] is obtained by acting (B) an alkenyl halide expressed by the formula: R4-Y [R4 is a (substituted) 1-alkenyl; Y is a halogen], (C) a nickel catalyst, (D) a metal having

    CEPHALOSPORIN PYRIDINIM COMPLEX
    5.
    发明专利
    CEPHALOSPORIN PYRIDINIM COMPLEX 失效

    公开(公告)号：JPH10120687A

    公开(公告)日：1998-05-12

    申请号：JP28523397

    申请日：1997-10-17

    申请人： HOFFMANN LA ROCHE

    发明人： ANGEHRN PETER ,  HEINZE-KRAUSS INGRID ,  PAGE MALCOLM ,  WEISS URS

    IPC分类号： C07D501/04 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D501/00 ,  C07D501/16 ,  C07D501/24 ,  C07D501/56

    摘要： PROBLEM TO BE SOLVED: To obtain the subject derivative, which is an antibiotic substance, comprising a specific cephalosporin pyridinium derivative, having a strong and a wide range of antimicrobial activities and especially effective against methicillin-resistant Staphylococcus aureus(MRSA), enterococci, pneumococci, etc. SOLUTION: This compound is a new cephalosporin pyridinium derivative represented by formula I [R is H, a lower alkyl, a cycloalkyl or acetyl; X is CH or N; (n) is 0, 1 or 2; (m) is 0 or 1; R is H, a lower alkyl, an ω- hydroxyalkyl, benzyl, a lower alkyl-(substituted)heterocyclic group or a group represented by the formula CH2 CONR R (R and R are each H, an ω- hydroxyalkyl, phenyl, benzyl, naphthyl, heterocylic group, etc.)] and is useful as an antimicrobial agent, etc., effective against methicillin-resistant Staphylococcus aureus(MRSA), enterococci, pneumococci, etc. The compound is obtained by reacting a compound represented by formula II with a heterocyclic carboxylic acid compound represented by formula III (R is H or an amino-protecting group).