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26 条记录 (耗时 0.016 秒)

    5.
    发明专利
    失效

    公开(公告)号：JPH08502720A

    公开(公告)日：1996-03-26

    申请号：JP51268693

    申请日：1993-01-15

    IPC分类号： A61K38/00 ,  A61K39/00 ,  A61K39/02 ,  A61K39/395 ,  A61K39/44 ,  A61K49/00 ,  A61P35/00 ,  C07K14/195 ,  C07K14/29 ,  C07K16/12 ,  C12N1/20 ,  C12N15/09 ,  C12P21/02 ,  C12P21/08 ,  C12Q1/68 ,  C12R1/01 ,  G01N33/569

    摘要： A method of diagnosing cat scratch disease and a method of diagnosing bacillary angiomatosis in a subject by detecting the presence of Rochalimaea henselae or an immunogenically specific determinant thereof in the subject is provided. Also provided is a vaccine comprising an immunogenic amount of a nonpathogenic Rochalimaea henselae or an immunogenically specific determinant thereof and a pharmaceutically acceptable carrier. A method of diagnosing Rochalimaea quintana infection in a subject by detecting the presence of a nucleic acid specific to Rochalimaea quintana in a sample from the subject is provided. A purified heat shock protein of Rochalimaea is provided.

    Peptide sequence and peptide composition
    6.
    发明专利
    Peptide sequence and peptide composition 有权
    肽类序列和肽组成

    公开(公告)号：JP2013240330A

    公开(公告)日：2013-12-05

    申请号：JP2013122060

    申请日：2013-06-10

    申请人： Peptcell Ltd ,  ペプトセル リミテッド

    发明人： STOLOFF GREGORY ALAN ,  CAPARROS-WANDERLEY WILSON ROMERO

    IPC分类号： C12N15/09 ,  A61K38/00 ,  A61K39/00 ,  A61K39/39 ,  A61K48/00 ,  A61P31/04 ,  A61P31/12 ,  A61P33/00 ,  A61P33/02 ,  A61P33/06 ,  A61P33/10 ,  A61P43/00 ,  C07K7/06 ,  C07K7/08 ,  C07K14/01 ,  C07K14/08 ,  C07K14/18 ,  C07K14/195 ,  C07K14/20 ,  C07K14/29 ,  C07K14/44 ,  C07K14/445

    CPC分类号： C07K14/43577 ,  A61K38/00 ,  A61K39/005 ,  A61K2039/53 ,  Y10S530/806 ,  Y10S530/855 ,  Y10S530/858

    摘要： PROBLEM TO BE SOLVED: To provide a polypeptide composition capable of inducing immune response against a plurality of arthropod-mediated diseases in a vertebrate, and to provide a vaccine against the arthropod-mediated diseases, using the polypeptide composition.SOLUTION: There is provided a polypeptide composition comprising one or more polypeptides which are immunogenic in a vertebrate such that they cause the vertebrate to produce immune system cells capable of recognizing at least one epitope derived from an arthropod saliva protein fraction. The arthropod saliva protein fraction has a molecular weight of 40 kDA or less, and the polypeptides are selected independently from specific polypeptide sequences and partial sequences thereof and having seven or more amino acid residues; or from polypeptide sequences contained in one or more of polypeptide sequences having 85% or more homology with one or more of the above sequences. There is also provided a vaccine composition containing the composition.

    摘要翻译： 要解决的问题：提供能够在脊椎动物中诱导针对多种节肢动物介导的疾病的免疫应答的多肽组合物，并使用多肽组合物提供针对节肢动物介导的疾病的疫苗。解决方案：提供了一种 多肽组合物，其包含在脊椎动物中具有免疫原性的一种或多种多肽，使得它们引起脊椎动物产生能识别源自节肢动物唾液蛋白质级分的至少一种表位的免疫系统细胞。 节肢动物唾液蛋白质级分的分子量为40kDA以下，多肽独立于具体的多肽序列及其部分序列选择并具有7个以上的氨基酸残基; 或者与一个或多个与一个或多个上述序列具有85％或更多同源性的多肽序列中所含的多肽序列。 还提供含有该组合物的疫苗组合物。