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    피리딘-2,3-디카복실레이트 화합물의 제조를 위한 방법 및중간체
    21.
    发明公开
    피리딘-2,3-디카복실레이트 화합물의 제조를 위한 방법 및중간체 有权
    用于生产吡啶-2,3-二羧酸酯化合物的方法和中间体

    公开(公告)号：KR1020000006107A

    公开(公告)日：2000-01-25

    申请号：KR1019990021723

    申请日：1999-06-11

    Applicant: 바스프 에스이

    Inventor： 우웬-슈

    IPC: C07D213/00

    CPC classification number: C07D213/80 ,  C07C229/30 ,  Y02P20/582

    Abstract: PURPOSE: The production method of the pyridine-2,3-dicarboxylic derivative is safe, effective, economic and an environmental harmony. CONSTITUTION: The pyridine-2,3-dicarboxylic derivative is effectively and economically produced: as the intermediate to usefully produce the herbicide 2-(2-imidazol-2-il-) nicotinic acid, the ester, and the hydrochlorides; by containing the dangerous oxidizing method such as the nitric acid oxidation of the 2,3-dialkyl or the quinolon precursor, or the base peroxide oxidation; the common new synthesis of the pyridine-2,3-dicarboxylic rate using the oxaloacetate diester or using the metal salt thereof produced the product of low degree of purity; by using the amino alkoxy( or alkyltio) oxaloacetate diester compound as the starting material or as the intermediate.

    Abstract translation: 目的：吡啶-2,3-二羧酸衍生物的制备方法安全，有效，经济，环保。 构成：有效和经济地制备吡啶-2,3-二羧酸衍生物：作为有用地生产除草剂2-（2-咪唑-2-基） - 烟酸，酯和盐酸盐的中间体; 通过含有2,3-二烷基或喹诺酮前体的硝酸氧化或碱过氧化物氧化等危险氧化方法; 使用草酰乙酸二酯或使用其金属盐的吡啶-2,3-二羧酸速率的常见新合成产生了低纯度的产物; 通过使用氨基烷氧基（或烷基氧基）草酰乙酸酯二酯化合物作为原料或作为中间体。

    피리딜 화합물의 제조방법
    27.
    发明授权
    피리딜 화합물의 제조방법 失效
    制备吡啶化合物的方法

    公开(公告)号：KR1019880001466B1

    公开(公告)日：1988-08-11

    申请号：KR1019830000440

    申请日：1983-02-03

    Applicant: 더 웰컴 파운데이션 리미티드

    Inventor： 지오프리죠지코커 ,  죤윌리암애디슨핀들래이

    IPC: C07D401/06 ,  C07D213/00

    CPC classification number: C07D213/79 ,  A61K31/44 ,  A61K31/485 ,  C07D213/55 ,  C07D213/56 ,  C07D213/61 ,  C07D295/155 ,  C07D405/04 ,  A61K2300/00

    Abstract: 3,3-Diarylpropylamine derivs. of formula (I) [R1=C1-7 trivalent aliphatic hydrocarbon or a direct bond; R2, R3=H, C1-4 alkyl or NR2R3=is 4- to 6-membered N-contg. heterocyclic ring; R4=H, halo, OH, CN, C1-4 alkoxy or C1-4 alkyl opt. substd. by one to three halo; X=- N= or -CH=; A and B are each H or together form an additional c-c bond , and their salts, ester or amide derivs. are prepd. Thus, (E,E)-II was prepd. from 2,6-di-bromopyridine, 4MeC6H4CN, Et2OCH2P(O) (OEt)2, and (2-pyrrolidinoethyl) triphenylphosphonium bromide in 5 steps. (II) has an antihistaminic PA2 of 8.6. (I) exhibit antihistamine activity for treating nasal congestion, rhinitis, urticaria, etc..

    Abstract translation: 3,3-二芳基丙胺衍生物。 的式（I）[R1 = C1-7三价脂族烃或直接键; R2，R3 = H，C1-4烷基或NR2R3 =为4-至6-元N-contg。 杂环 R4 = H，卤素，OH，CN，C1-4烷氧基或C1-4烷基选择。 substd。 一到三个光环; X = -N =或-CH =; A和B各自为H或一起形成另外的C-C键，以及它们的盐，酯或酰胺衍生物。 是prepd 因此，（E，E）-II是制备的。 由2,6-二溴吡啶，4MeC 6 H 4 CN，Et 2 OCH 2 P（O）（OEt）2和（2-吡咯烷基乙基）三苯基溴化鏻组成。 （II）具有8.6的抗组胺PA2。 （I）表现出治疗鼻充血，鼻炎，荨麻疹等的抗组胺活性。

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