公开(公告)号：US20100145301A1

公开(公告)日：2010-06-10

申请号：US12522267

申请日：2008-02-07

申请人： Elad Magal

发明人： Elad Magal

IPC分类号： A61M5/142 ,  A61K38/22

CPC分类号： A61M5/14276 ,  A61F5/0003 ,  A61F5/0036 ,  A61K9/0065 ,  A61M2005/1726 ,  A61M2210/1053 ,  A61M2210/1057 ,  A61M2210/106 ,  A61M2230/04 ,  A61M2230/08 ,  A61M2230/60

摘要： Methods of administering an active agent such as an active pharmaceutical ingredient by spraying a composition comprising the active agent at a luminal wall of the gastrointestinal tract are disclosed. Also disclosed are devices for administering a composition suitable for implementing the disclosed method. Also disclosed is the use of a peptide as an active agent for the manufacture of a sprayable composition for use in the treatment of a subject by gastrointestinal administration.

摘要翻译： 公开了通过在胃肠道的腔壁处喷雾包含活性剂的组合物来施用活性剂如活性药物成分的方法。 还公开了用于施用适于实施所公开的方法的组合物的装置。 还公开了肽作为活性剂用于制造用于通过胃肠给药治疗受试者的可喷雾组合物的用途。

公开(公告)号：US20100114150A1

公开(公告)日：2010-05-06

申请号：US12525855

申请日：2008-02-07

申请人： Elad Magal

发明人： Elad Magal

IPC分类号： A61M29/02

CPC分类号： A61F5/0079

摘要： A device useful for treatment of conditions relating to an eating disorder comprises: a) a duodenum obstructing component configured to partially obstruct the lumen of a duodenum in which deployed, preferably so as to reduce the rate of passage of materials through the duodenum; and b) an anchoring component configured to substantially maintain a position of the obstructing component inside a duodenum wherein deployed. The obstructing component does not block entry of food into the duodenum but rather causes a given volume of food that enters the duodenum to induce a greater degree of satiety and/or to induce a perception of satiety for a longer period of time and/or to induce a perception of satiety faster than otherwise.

摘要翻译： 用于治疗与进食障碍有关的病症的装置包括：a）十二指肠阻塞部件，构成为部分地阻塞十二指肠的内腔，其中部署，优选地降低材料通过十二指肠的速度; 以及b）锚定部件，其构造成基本上保持所述阻塞部件位于十二指肠内部的部位。 阻塞部件不阻止食物进入十二指肠，而是导致进入十二指肠的给定体积的食物诱导更大程度的饱腹感和/或诱发饱腹感更长时间和/或 诱导感觉的饱腹感比其他更快。

公开(公告)号：US20070265598A1

公开(公告)日：2007-11-15

申请号：US11663222

申请日：2005-09-29

申请人： Yael Karasik

发明人： Yael Karasik

IPC分类号： A61K9/22

CPC分类号： A61K38/26 ,  A61B5/04884 ,  A61B5/053 ,  A61B5/42 ,  A61B5/4238 ,  A61F5/0026 ,  A61F5/003 ,  A61F5/004 ,  A61K38/22 ,  A61K38/2207 ,  A61M5/14276 ,  A61M5/1723 ,  A61M2005/1726 ,  A61M2210/1053 ,  A61M2210/1057 ,  A61M2230/63 ,  A61N1/36007

摘要： An apparatus and a method for treating a weight disorder in a subject are provided. The apparatus comprising an implantable device such as an inflatable balloon and electrodes capable of sensing a physiological change associated with food ingestion or hunger and a mechanism adapted for directly stimulating a region such as the duodenum which is responsive to a gastrointestinal satiety agent, such a mechanism can be a drug reservoir containing a drug such as CCK or analogs thereof which is contained within an inflatable balloon being implantable in a stomach of the subject. The apparatus and method provided here combine synergistic approaches to limiting meal size, i.e., chemo and mechano receptor activation of vagal satiety stimuli, electric stimulation of specific vagal pathways and limitations of gastric space.

摘要翻译： 提供了一种用于治疗受试者体重障碍的装置和方法。 所述装置包括可植入装置，例如可充气球囊和能够感测与食物摄入或饥饿相关的生理变化的电极，以及适于直接刺激对胃肠饱腹感者有响应的十二指肠的区域的机制， 可以是含有诸如CCK或其类似物的药物的药物储存器，其包含在可植入对象的胃中的可充气球囊内。 这里提供的装置和方法结合了限制餐尺寸的协同方法，即迷走神经饱腹感刺激的化学和机械受体激活，特定迷走神经通路的电刺激和胃空间的限制。