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    Use of neuregulin-β as an indicator and/or target
    1.
    发明授权
    Use of neuregulin-β as an indicator and/or target 失效
    使用神经调节蛋白-β作为指标和/或靶标

    公开(公告)号：US08546086B2

    公开(公告)日：2013-10-01

    申请号：US13035352

    申请日：2011-02-25

    申请人： Andre Schrattenholz

    发明人： Andre Schrattenholz

    IPC分类号： C07K7/06 ,  C07K14/475 ,  C07K16/22 ,  G01N33/53

    CPC分类号： C07K14/4756 ,  A61K38/00

    摘要： The invention relates, inter alia, to the use of neuregulin-β as an indicator in a method for detecting a neuronal process. The invention furthermore relates to the use of neuregulins, preferably a neuregulin isoform having an isoelectric point in the range from pH 4.3 to 5.0, as a target for detecting and/or exerting an influence on neuronal processes, in particular for exerting an influence on long-term memory. Neuregulins, in particular neuregulin-β and also substances which exert an influence on the status, i.e. the expression and/or post-translational modification, of neuregulin-β, can therefore be used as agents for controlling the course of, treating and/or alleviating neuronal diseases, e.g. Alzheimer's disease.

    摘要翻译： 本发明尤其涉及在神经元过程检测方法中使用神经调节蛋白-β作为指示剂。 本发明还涉及使用神经调节蛋白，优选具有等电点在pH 4.3至5.0范围内的神经调节蛋白同种型作为检测和/或发挥对神经元过程的影响的目标，特别是对长时间的影响 - 记忆 因此，神经调节蛋白，特别是神经调节蛋白β以及对神经调节蛋白-β的状态（即表达和/或翻译后修饰）产生影响的物质可用作控制治疗和/或治疗的过程， 减轻神经元疾病，例如 阿尔茨海默氏病。

    USE OF NEUREGULIN-ß AS AN INDICATOR AND/OR TARGET
    3.
    发明申请
    USE OF NEUREGULIN-ß AS AN INDICATOR AND/OR TARGET 失效
    用作神经元ß作为指示剂和/或目标

    公开(公告)号：US20110244507A1

    公开(公告)日：2011-10-06

    申请号：US13035352

    申请日：2011-02-25

    申请人： ANDRÉ SCHRATTENHOLZ

    发明人： ANDRÉ SCHRATTENHOLZ

    IPC分类号： C12Q1/02 ,  C12N5/079

    CPC分类号： C07K14/4756 ,  A61K38/00

    摘要： The invention relates, inter alia, to the use of neuregulin-β as a target in a screening method for active compounds, in particular for exerting an influence on changes in calcium concentration which are mediated by glutamate receptors.The invention furthermore relates to the use of neuregulins, preferably a neuregulin isoform having an isoelectric point in the range from pH 4.3 to 5.0, as a target for detecting and/or exerting an influence on neuronal processes, in particular for exerting an influence on long-term memory. Neuregulins, in particular neuregulin-β and also substances which exert an influence on the status, i.e. the expression and/or post-translational modification, of neuregulin-β, can therefore be used as agents for controlling the course of, treating and/or alleviating neuronal diseases, e.g. Alzheimer's disease.

    摘要翻译： 本发明特别涉及使用神经调节蛋白 - 作为活性化合物的筛选方法的目标，特别是对由谷氨酸受体介导的钙浓度变化的影响。 本发明还涉及使用神经调节蛋白，优选具有等电点在pH 4.3至5.0范围内的神经调节蛋白同种型作为检测和/或发挥对神经元过程的影响的目标，特别是对长时间的影响 - 记忆 神经调节蛋白，特别是神经调节蛋白 并且因此也可以使用对神经调节蛋白 - bgr的状态，即表达和/或翻译后修饰产生影响的物质，作为用于控制神经元疾病进程，治疗和/或缓解神经元疾病的药剂。 阿尔茨海默氏病。