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1.发明申请NEUREGULIN ISOFORMS,NEUREGULIN POLYPEPTIDES AND USES THEREOF 审中-公开NEUREGULIN ISOFORMS，NEUREGULIN POLYPEPTIDES及其用途公开(公告)号：US20130072437A1
公开(公告)日：2013-03-21
申请号：US13700209
申请日：2011-05-27
CPC分类号： C07K14/4756 , A61K9/0019 , A61K38/00 , A61K38/17 , A61K38/1883 , A61K45/06 , C07K19/00 , C12N5/06 , C12N5/0619 , C12N2501/13 , C12N2506/08 , G01N33/6896 , G01N2333/4756 , G01N2800/2835
摘要： The present invention relates to new therapeutic and diagnostic uses of soluble neuregulin-1 isoforms and polypeptides, particularly neurological disorders.
摘要翻译： 本发明涉及可溶性神经调节蛋白-1同种型和多肽，特别是神经障碍的新的治疗和诊断用途。
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2.发明授权Peptide fragment of respiratory syncytial virus protein G, immunogenic agent, pharmaceutical composition containing it and preparation method 失效呼吸道合胞病毒蛋白G，免疫原性药物，含有药物组合物的肽片段及其制备方法公开(公告)号：US07220545B2
公开(公告)日：2007-05-22
申请号：US10655855
申请日：2003-09-05
申请人： Hans Binz , Thien Ngoc N′Guyen , Thierry Baussant , Michel Trudel
发明人： Hans Binz , Thien Ngoc N′Guyen , Thierry Baussant , Michel Trudel
IPC分类号： C12Q1/68
CPC分类号： A61K39/155 , A61K38/00 , A61K39/12 , A61K47/646 , A61K2039/55505 , A61K2039/55566 , A61K2039/6037 , A61K2039/6068 , A61K2039/6081 , C07K14/005 , C07K14/26 , C07K14/765 , C07K2319/00 , C07K2319/40 , C12N2760/18522 , C12N2760/18534
摘要： A polypeptide useful as an immunogen element and characterised in that it is carried on the peptide sequence between amino acid residues 130–230 of the G protein sequence of the human respiratory syncytial virus of sub-groups A and B, or of the bovine respiratory syncytial virus, or on a sequence at least 80% homologous thereto. An immunogenic agent or pharmaceutical composition containing said polypeptide, and a method for preparing same, are also disclosed.
摘要翻译： 可用作免疫原元件的多肽，其特征在于其携带在亚组A和B之间的人呼吸道合胞病毒的G蛋白序列的氨基酸残基130-230或牛呼吸道合胞体之间的肽序列上 或与至少80％同源的序列上。 还公开了含有所述多肽的免疫原性试剂或药物组合物及其制备方法。
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3.发明授权Method for preparing a polypeptide soluble in an aqueous solvent in the absence of detergent 失效在不含洗涤剂的情况下制备可溶于水性溶剂的多肽的方法公开(公告)号：US07125696B2
公开(公告)日：2006-10-24
申请号：US10169953
申请日：2001-01-04
CPC分类号： C07K14/26 , C07K1/34 , Y10T436/25 , Y10T436/25125 , Y10T436/25375
摘要： A invention concerns a novel method for preparing a polypeptide soluble in an aqueous solvent in the absence of detergent, and polypeptides obtainable by said method. The invention also concerns the use of said polypeptides, in particular for preparing medicines or vaccines, for fighting against bacterial and viral infections or cancers.
摘要翻译： 本发明涉及一种在不存在洗涤剂的情况下制备可溶于水性溶剂的多肽的新方法，以及可通过所述方法获得的多肽。 本发明还涉及所述多肽的用途，特别是用于制备药物或疫苗以抵抗细菌和病毒感染或癌症。
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4.发明授权Carrier protein having an adjuvant effect, immunogenic complex containing it, process for their preparation, nucleotide sequence and vaccine 失效具有佐剂效应的载体蛋白，含有其的免疫原性复合物，其制备方法，核苷酸序列和疫苗公开(公告)号：US06780420B1
公开(公告)日：2004-08-24
申请号：US09679750
申请日：2000-10-05
IPC分类号： A61K39108
CPC分类号： C07K14/005 , A61K39/385 , A61K2039/6068 , C07K14/26 , C07K2319/00 , C12N2760/18522 , Y10S530/806 , Y10S530/807 , Y10S530/825
摘要： The invention relates to an adjuvant product which is intended to improve the activity of a molecule when administered to a host, characterized in that it comprises at least one part of the P40 protein of Klebsiella pneumoniae or a protein having at least 80% homology with the P40 protein of Klebsiella pneumoniae. The invention also relates to nucleotide sequences which encode these peptides or proteins and to the use of these sequences as a medicament. More particularly, such DNA sequences can be used in compositions which are intended for immunization by the intramuscular or intradermal route.
摘要翻译： 本发明涉及一种佐剂产品，其旨在在施用于宿主时改善分子的活性，其特征在于其包含至少一部分肺炎克雷伯杆菌的P40蛋白或与其中至少80％的同源性的蛋白质 肺炎克雷伯杆菌的P40蛋白。 本发明还涉及编码这些肽或蛋白质的核苷酸序列以及这些序列作为药物的用途。 更具体地，这样的DNA序列可以用于旨在通过肌内或皮内途径免疫的组合物中。
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5.发明授权Carrier protein having an adjuvant effect, immunogenic complex containing it, process for their preparation, nucleotide sequence and vaccine 失效具有佐剂效应的载体蛋白，含有其的免疫原性复合物，其制备方法，核苷酸序列和疫苗公开(公告)号：US06197929B1
公开(公告)日：2001-03-06
申请号：US08836500
申请日：1997-08-11
IPC分类号： C07K100
CPC分类号： C07K14/005 , A61K39/385 , A61K2039/6068 , C07K14/26 , C07K2319/00 , C12N2760/18522 , Y10S530/806 , Y10S530/807 , Y10S530/825
摘要： The invention relates to an adjuvant product which is intended to improve the activity of a molecule when administered to a host, characterized in that it comprises at least one part of the P40 protein of Klebsiella pneumoniae or a protein having at least 80% homology with the P40 protein of Klebsiella pneumoniae. The invention also relates to nucleotide sequences which encode these peptides or proteins and to the use of these sequences as a medicament. More particularly, such DNA sequences can be used in compositions which are intended for immunization by the intramuscular or intradermal route.
摘要翻译： 本发明涉及一种佐剂产品，其旨在在施用于宿主时改善分子的活性，其特征在于其包含至少一部分肺炎克雷伯杆菌的P40蛋白或与其中至少80％的同源性的蛋白质 肺炎克雷伯杆菌的P40蛋白。 本发明还涉及编码这些肽或蛋白质的核苷酸序列以及这些序列作为药物的用途。 更具体地，这样的DNA序列可以用于旨在通过肌内或皮内途径免疫的组合物中。
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6.发明授权Peptide fragment of respiratory syncytial virus protein G, immunogenic agent, pharmaceutical composition containing it and preparation method 失效呼吸道合胞病毒蛋白G，免疫原性药物，含有药物组合物的肽片段及其制备方法公开(公告)号：US06616930B2
公开(公告)日：2003-09-09
申请号：US10091257
申请日：2002-03-05
申请人： Hans Binz , Thien Ngoc N'Guyen , Thierry Baussant , Michel Trudel
发明人： Hans Binz , Thien Ngoc N'Guyen , Thierry Baussant , Michel Trudel
IPC分类号： A61K39155
CPC分类号： A61K39/155 , A61K38/00 , A61K39/12 , A61K47/646 , A61K2039/55505 , A61K2039/55566 , A61K2039/6037 , A61K2039/6068 , A61K2039/6081 , C07K14/005 , C07K14/26 , C07K14/765 , C07K2319/00 , C07K2319/40 , C12N2760/18522 , C12N2760/18534
摘要： A polypeptide useful as an immunogen element and characterized in that it is carried on the peptide sequence between amino acid residues 130-230 of the G protein sequence of the human respiratory syncytial virus of sub-groups A and B, or of the bovine respiratory syncytial virus, or on a sequence at least 80% homologous thereto. An immunogenic agent or pharmaceutical composition containing said polypeptide, and methods for preparing and using the same, are also disclosed.
摘要翻译： 可用作免疫原元件的多肽，其特征在于其携带在亚组A和B之间的人呼吸道合胞病毒的G蛋白序列的氨基酸残基130-230或牛呼吸道合胞体之间的肽序列上 或与至少80％同源的序列上。 还公开了含有所述多肽的免疫原性试剂或药物组合物及其制备和使用方法。
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公开(公告)号：US06537556B1
公开(公告)日：2003-03-25
申请号：US09582876
申请日：2000-06-30
申请人： Hans Binz , Thien N'Guyen Ngoc , Thierry Baussant , Michel Trudel
发明人： Hans Binz , Thien N'Guyen Ngoc , Thierry Baussant , Michel Trudel
IPC分类号： A61K39155
CPC分类号： A61K39/155 , A61K38/00 , A61K39/12 , A61K47/646 , A61K2039/55505 , A61K2039/55566 , A61K2039/6037 , A61K2039/6068 , A61K2039/6081 , C07K14/005 , C07K14/26 , C07K14/765 , C07K2319/00 , C07K2319/40 , C12N2760/18522 , C12N2760/18534
摘要： A polypeptide useful as an immunogen element and characterized in that it is carried on the peptide sequence between amino acid residues 130-230 of the G protein sequence of the human respiratory syncytial virus of sub-groups A and B, or of the bovine respiratory syncytial virus, or on a sequence at least 80% homologous thereto. An immunogenic agent or pharmaceutical composition containing said polypeptide, and methods for preparing and using the same, are also disclosed.
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8.发明授权Peptide fragment of respiratory syncytial virus protein G, immunogenic agent, pharmaceutical composition containing it and preparation process 失效呼吸道合胞病毒蛋白G的肽片段，免疫原性药剂，含有它的药物组合物及其制备方法公开(公告)号：US06410030B1
公开(公告)日：2002-06-25
申请号：US09654289
申请日：2000-09-01
申请人： Hans Binz , Ngoc Thien N'Guyen , Thierry Baussant , Michel Trudel
发明人： Hans Binz , Ngoc Thien N'Guyen , Thierry Baussant , Michel Trudel
IPC分类号： A61K3912
CPC分类号： A61K39/155 , A61K38/00 , A61K39/12 , A61K47/646 , A61K2039/55505 , A61K2039/55566 , A61K2039/6037 , A61K2039/6068 , A61K2039/6081 , C07K14/005 , C07K14/26 , C07K14/765 , C07K2319/00 , C07K2319/40 , C12N2760/18522 , C12N2760/18534
摘要： A polypeptide useful as an immunogen element and characterized in that it is carried on the peptide sequence between amino acid residues 130-230 of the G protein sequence of the human respiratory syncytial virus of sub-groups A and B, or of the bovine respiratory syncytial virus, or on a sequence at least 80% homologous thereto. An immunogenic agent or pharmaceutical composition containing said polypeptide, and methods for preparing and using the same, are also disclosed.
摘要翻译： 可用作免疫原元件的多肽，其特征在于其携带在亚组A和B之间的人呼吸道合胞病毒的G蛋白序列的氨基酸残基130-230或牛呼吸道合胞体之间的肽序列上 或与至少80％同源的序列上。 还公开了含有所述多肽的免疫原性试剂或药物组合物及其制备和使用方法。
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公开(公告)号：US07408044B2
公开(公告)日：2008-08-05
申请号：US10815320
申请日：2004-04-01
IPC分类号： C07K1/00 , A61K39/385 , A61K39/00 , A61K39/02 , A61K45/00 , A61K39/108 , C12P21/04 , C12N15/09
CPC分类号： C07K14/005 , A61K39/385 , A61K2039/6068 , C07K14/26 , C07K2319/00 , C12N2760/18522 , Y10S530/806 , Y10S530/807 , Y10S530/825
摘要： The invention relates to an adjuvant product which is intended to improve the activity of a molecule when administered to a host, characterized in that it comprises at least one part of the P40 protein of Klebsiella pneumoniae or a protein having at least 80% homology with the P40 protein of Klebsiella pneumoniae. The invention also relates to nucleotide sequences which encode these peptides or proteins and to the use of these sequences as a medicament. More particularly, such DNA sequences can be used in compositions which are intended for immunization by the intramuscular or intradermal route.
摘要翻译： 本发明涉及一种佐剂产品，其旨在在施用于宿主时改善分子的活性，其特征在于其包含至少一部分肺炎克雷伯杆菌的P40蛋白或与其中至少80％的同源性的蛋白质 肺炎克雷伯杆菌的P40蛋白。 本发明还涉及编码这些肽或蛋白质的核苷酸序列以及这些序列作为药物的用途。 更具体地，这样的DNA序列可以用于旨在通过肌内或皮内途径免疫的组合物中。
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10.发明申请Carrier protein having an adjuvant effect, immunogenic complex containing it, process for their preparation, nucleotide sequence and vaccine 失效具有佐剂效应的载体蛋白，含有其的免疫原性复合物，其制备方法，核苷酸序列和疫苗公开(公告)号：US20060034870A1
公开(公告)日：2006-02-16
申请号：US10815320
申请日：2004-04-01
申请人： Hans Binz , Thierry Baussant , Jean-Francois Haeuw , Thien Nguyen
发明人： Hans Binz , Thierry Baussant , Jean-Francois Haeuw , Thien Nguyen
IPC分类号： A61K39/108 , C07K14/195
CPC分类号： C07K14/005 , A61K39/385 , A61K2039/6068 , C07K14/26 , C07K2319/00 , C12N2760/18522 , Y10S530/806 , Y10S530/807 , Y10S530/825
摘要： The invention relates to an adjuvant product which is intended to improve the activity of a molecule when administered to a host, characterized in that it comprises at least one part of the P40 protein of Klebsiella pneumoniae or a protein having at least 80% homology with the P40 protein of Klebsiella pneumoniae. The invention also relates to nucleotide sequences which encode these peptides or proteins and to the use of these sequences as a medicament. More particularly, such DNA sequences can be used in compositions which are intended for immunization by the intramuscular or intradermal route.
摘要翻译： 本发明涉及一种佐剂产品，其旨在在施用于宿主时改善分子的活性，其特征在于其包含至少一部分肺炎克雷伯杆菌的P40蛋白或与其中至少80％的同源性的蛋白质 肺炎克雷伯杆菌的P40蛋白。 本发明还涉及编码这些肽或蛋白质的核苷酸序列以及这些序列作为药物的用途。 更具体地，这样的DNA序列可以用于旨在通过肌内或皮内途径免疫的组合物中。
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