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1.发明申请METHODS OF TREATING SECONDARY BONE TUMORS WITH ANTIBODIES AGAINST PDGFR ALPHA 有权用抗PDGFR ALPHA治疗二次骨肿瘤的方法公开(公告)号：US20120034244A1
公开(公告)日：2012-02-09
申请号：US13276358
申请日：2011-10-19
IPC分类号： A61K39/395 , A61P35/00
CPC分类号： A61K38/17 , A61K39/395 , A61K39/39558 , A61K2039/505 , C07K16/2863 , C07K2317/21 , C07K2317/73 , C07K2317/76 , A61K2300/00
摘要： The invention provides methods of treating bone cancer, particularly metastatic bone cancer, by administering an IGF-IR antagonist and/or a PDGFRα antagonist. The invention also provides antibodies that bind to human PDGFRα and neutralize activation of the receptor. The invention further provides a methods for neutralizing activation of PDGFRα, and a methods of treating a mammal with a neoplastic disease using the antibodie alone or in combination with other agents.
摘要翻译： 本发明提供了通过施用IGF-1R拮抗剂和/或PDGFRα拮抗剂来治疗骨癌，特别是转移性骨癌的方法。 本发明还提供了结合人PDGFRα并中和受体活化的抗体。 本发明还提供了中和PDGFRα活化的方法，以及使用单独的抗生素或与其它药剂组合治疗具有肿瘤疾病的哺乳动物的方法。
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公开(公告)号：US20200062768A1
公开(公告)日：2020-02-27
申请号：US16610450
申请日：2018-05-01
申请人： Joseph M. SALVINO , Xin FENG , Alessandro FATATIS , Fei SHEN , Olimpia MEUCCI
发明人： Joseph M. SALVINO , Xin FENG , Alessandro FATATIS , Fei SHEN , Olimpia MEUCCI
IPC分类号： C07D487/04 , C07D519/00 , A61P35/00
摘要： The invention provides compounds that are fractalkine receptor agonists and useful in treating, preventing or minimizing metastasis in a subject diagnosed with cancer. The compounds of the invention are further useful in treating central nervous system diseases (such as, but not limited to, HIV Associated Neurocognitive Disorders (HAND), and/or Alzheimer's disease), pain, inflammation (such as, but not limited to, arthritis), cardiovascular disease (such as, but not limited to, undesired vascular smooth muscle proliferation, atherosclerosis, coronary vascular endothelial dysfunction, and/or coronary artery disease), and/or multiple sclerosis.
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公开(公告)号：US08435993B2
公开(公告)日：2013-05-07
申请号：US13312540
申请日：2011-12-06
IPC分类号： A01N43/58 , A01N43/60 , A01N43/40 , A61K31/495 , A61K31/50 , A61K31/445 , A61K51/00 , C07D211/00 , C07D401/00 , C07D241/36 , C07D471/00 , A61M36/14
CPC分类号： C07D487/04 , A61K31/451 , A61K31/453 , A61K31/7088 , A61K39/3955 , C07D403/04 , C07K16/28
摘要： The present invention includes compositions that are useful in preventing or treating metastasis in a subject diagnosed with cancer. The present invention also includes methods of preventing or treating metastasis in a subject diagnosed with cancer, wherein the method comprises administering to the subject in need thereof an effective amount of a pharmaceutical formulation comprising at least one pharmaceutically acceptable carrier and at least one CX3CR1 or fractalkine antagonist.
摘要翻译： 本发明包括可用于预防或治疗患有癌症的受试者的转移的组合物。 本发明还包括预防或治疗患有癌症的受试者的转移的方法，其中所述方法包括向有需要的受试者施用有效量的药物制剂，其包含至少一种药学上可接受的载体和至少一种CX3CR1或fractalkine 拮抗剂。
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4.发明授权Compounds useful for inhibiting metastasis from cancer and methods using same 有权可用于抑制癌症转移的化合物及使用其的方法公开(公告)号：US09375474B2
公开(公告)日：2016-06-28
申请号：US13776220
申请日：2013-02-25
IPC分类号： A01N43/58 , A01N43/60 , A61K31/495 , A61K31/50 , A01N43/40 , A61K31/445 , C07D499/26 , A61K39/395 , C07D487/04 , A61K31/451 , A61K31/453 , A61K31/7088 , C07D403/04 , C07K16/28
CPC分类号： C07D487/04 , A61K31/451 , A61K31/453 , A61K31/7088 , A61K39/3955 , C07D403/04 , C07K16/28
摘要： The present invention includes compositions that are useful in preventing or treating metastasis in a subject diagnosed with cancer. The present invention also includes methods of preventing or treating metastasis in a subject diagnosed with cancer, wherein the method comprises administering to the subject in need thereof an effective amount of a pharmaceutical formulation comprising at least one pharmaceutically acceptable carrier and at least one CX3CR1 or fractalkine antagonist.
摘要翻译： 本发明包括可用于预防或治疗患有癌症的受试者的转移的组合物。 本发明还包括预防或治疗患有癌症的受试者的转移的方法，其中所述方法包括向有需要的受试者施用有效量的药物制剂，其包含至少一种药学上可接受的载体和至少一种CX3CR1或fractalkine 拮抗剂。
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5.发明授权Methods of treating secondary bone tumors with antibodies against PDGFR alpha 有权用针对PDGFRα的抗体治疗继发性骨肿瘤的方法公开(公告)号：US08425911B2
公开(公告)日：2013-04-23
申请号：US13276358
申请日：2011-10-19
IPC分类号： A61K39/395 , A61P35/00
CPC分类号： A61K38/17 , A61K39/395 , A61K39/39558 , A61K2039/505 , C07K16/2863 , C07K2317/21 , C07K2317/73 , C07K2317/76 , A61K2300/00
摘要： The invention provides methods of treating bone cancer, particularly metastatic bone cancer, by administering a PDGFR alpha antagonist. The invention further provides methods of treating a mammal with a neoplastic disease using the antibodies alone or in combination with other agents.
摘要翻译： 本发明提供了通过施用PDGFRα拮抗剂治疗骨癌，特别是转移性骨癌的方法。 本发明还提供了使用单独的抗体或与其它药剂组合治疗具有肿瘤疾病的哺乳动物的方法。
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