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1.发明授权公开(公告)号：US11776115B2
公开(公告)日：2023-10-03
申请号：US16251730
申请日：2019-01-18
Applicant: Biocellvia
Inventor： Jean-Claude Gilhodes , Yvon Julé , Tomi Florent
IPC: G06T7/00 , G06T7/136 , G06T7/13 , G06T11/00 , G06T7/62 , G06V10/50 , G06V20/69 , G06F18/211 , G06F18/2431
CPC classification number: G06T7/0012 , G06F18/211 , G06F18/2431 , G06T7/13 , G06T7/136 , G06T7/62 , G06T11/001 , G06V10/50 , G06V20/695 , G06T2207/20072 , G06T2207/30061 , G06T2207/30101 , G06T2207/30242 , G06V2201/031
Abstract: A method for determining a quantity of interest related to the density of organic tissue starts with a digital representation of a histological image of the tissue. The digital representation is converted to a binary image, to discriminate pixels that represent tissue of interest in the image. A box filter is applied to values of the pixels of interest to obtain a tissue density value for each pixel of interest. A quantity of interest is computed, based upon the tissue density values for the pixels of interest. A tangible representation of the computed quantity of interest, such as a numerical value, a graph, or a color representation, is displayed or otherwise presented via an interface.
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公开(公告)号：US20210264596A1
公开(公告)日：2021-08-26
申请号：US17256316
申请日：2019-06-28
Applicant: BIOCELLVIA
Inventor： Yvon JULE , Florent TOMI , Jean-Claude GILHODES
Abstract: A method for producing a multiparameter graphic indicator relating to a remodelling of the human or animal bronchial epithelium from a digital representation of a histological section of a lung comprising one or more components, each of which describes a wall enclosing a lumen. Such a method makes it possible, in particular, to estimate one or more quantities of interest relating to one or more components in order to produce a graphical representation describing the quantity or quantities of interest so as to assist with diagnosing a disease or analyzing the effectiveness of a molecule for therapeutic purposes. The method is implemented by a processing unit of an electronic object of a histological analysis system.
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Patent Agency Ranking
3.发明申请公开(公告)号：US20200349700A1
公开(公告)日：2020-11-05
申请号：US16930602
申请日：2020-07-16
Applicant: BIOCELLVIA , The United States of America, as represented by the Secretary, Department of Health and Human Servic
Inventor： Jean-Claude Gilhodes , Yvon Julé , Tomi Florent , Bernadette R. Gochuico, M.D. , Damien Barbes , Karine Bertotti
Abstract: A method for determining a quantity of interest related to the density of organic tissue starts with a digital representation of a histological image of the tissue. The digital representation is converted to a binary image, to discriminate pixels that represent tissue of interest in the image. A box filter is applied to values of the pixels of interest to obtain a tissue density value for each pixel of interest. A quantity of interest is computed, based upon the tissue density values for the pixels of interest. A tangible representation of the computed quantity of interest, such as a numerical value, a graph, or a color representation, is displayed or otherwise presented via an interface. Prior to forming the digital representation, the tissue can be stained to distinguish particular types of tissue for removal or enhancement in the determination of the quantity of interest.
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4.发明申请公开(公告)号：US20190228260A1
公开(公告)日：2019-07-25
申请号：US16251730
申请日：2019-01-18
Applicant: Biocellvia
Inventor： Jean-Claude Gilhodes , Yvon Julé , Tomi Florent
Abstract: A method for determining a quantity of interest related to the density of organic tissue starts with a digital representation of a histological image of the tissue. The digital representation is converted to a binary image, to discriminate pixels that represent tissue of interest in the image. A box filter is applied to values of the pixels of interest to obtain a tissue density value for each pixel of interest. A quantity of interest is computed, based upon the tissue density values for the pixels of interest. A tangible representation of the computed quantity of interest, such as a numerical value, a graph, or a color representation, is displayed or otherwise presented via an interface.
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5.发明公开公开(公告)号：US20240265532A1
公开(公告)日：2024-08-08
申请号：US18556411
申请日：2022-04-19
Applicant: Biocellvia
Inventor： Cindy SERDJEBI , Damien BARBES , Bastien LEPOIVRE , Karine BERTOTTI
CPC classification number: G06T7/0012 , G06T7/62 , G06V20/695 , G06T2207/10024 , G06T2207/20036 , G06T2207/30024 , G06T2207/30096 , G06T2207/30101
Abstract: The invention relates to a method for producing a morphometric quantity of interest for a section of a human or animal organ on the basis of a first digital representation of a histological slide that has been subjected to a staining step that causes the pixels of said first digital representation to become different colours depending on whether said pixels describe emptiness, tissue or muscle cells. Said method especially consists in identifying pixels describing at least one polygon of interest in digital representations created from the first digital representation, in discerning, per polygon of interest, a lumen, an intima and a media of a vessel, and in producing at least one morphometric measurement of said vessel. Such a method comprises a step of producing a morphometric quantity of interest for the organ on the basis of said morphometric measurements of the identified vessels.
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公开(公告)号：US20230117179A1
公开(公告)日：2023-04-20
申请号：US17907035
申请日：2020-03-24
Applicant: Biocellvia
Inventor： Yvon JULE , Florent TOMI , Damien BARBES , Karine BERTOTTI
Abstract: The invention relates to a method for producing variables of interest relating to human or animal hepatic tissue from a digital representation of a histological section. Such a method is intended to be implemented by a unit for processing a medical imaging system to automatically and quickly provide diagnosis assistance, in particular for NASH, to healthcare personnel. The variables of interest respectively describe a level of steatosis of the hepatic tissue, a level of fibrosis in the portal, central and perisinusoidal areas of the hepatic lobule and a level of inflammation of the hepatic tissue. A method according to the invention further provides for producing a multiparametric indicator in the form of graphical representations arranged to be displayed by an output human-machine interface of the medical imaging system.
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公开(公告)号：US20210174508A1
公开(公告)日：2021-06-10
申请号：US17256143
申请日：2019-06-28
Applicant: Biocellvia
Inventor： Yvon JULE , Florent TOMI , Jean-Claude GILHODES
Abstract: The invention concerns a method for producing a multiparameter graphic indicator relating to a remodelling of human or animal pulmonary alveoli from a digital representation of a histological section of a lung comprising one or more components each of which describes a wall enclosing a lumen. The method can estimate one or more quantities of interest relating to one or more components in order to produce a graphic representation describing the quantity or quantities of interest in order to provide an aid for diagnosis of a disease or for analysis of the therapeutic effectiveness of molecules. The method is implemented by a processing unit of an electronic object of the histological analysis system.
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