公开(公告)号：US07745115B2

公开(公告)日：2010-06-29

申请号：US10817102

申请日：2004-04-01

Applicant: Page W. Caufield ,  Deepak Saxena ,  Michael C. Alfano

Inventor： Page W. Caufield ,  Deepak Saxena ,  Michael C. Alfano

IPC: C12Q1/68 ,  G01N33/554 ,  C12N1/20

CPC classification number: G01N1/00 ,  G01N2001/021 ,  G01N2001/022

Abstract: Provided is a method of surveillance for hazardous materials, e.g., chemical, biological and radiological agents. The method comprises assaying a sample derived from materials collected from a sample domain for the presence of a chemical, biological, or radiological agent. The sample domain comprises at least one collection point from which the materials are collected in a pre-existing operation unrelated to surveillance.

Abstract translation: 提供了用于危险材料的监测方法，例如化学，生物和放射剂。 该方法包括测定衍生自从样品区域收集的材料的样品，用于存在化学，生物或放射性试剂。 样本域包括至少一个收集点，在该收集点中，物料在与监视无关的预先存在的操作中被收集。

公开(公告)号：US20120315226A1

公开(公告)日：2012-12-13

申请号：US13433794

申请日：2012-03-29

Applicant: Racquel Z. LeGeros ,  Haijing Gu ,  Dindo Mijares ,  Deepak Saxena ,  Sudharani Bodepudi

Inventor： Racquel Z. LeGeros ,  Haijing Gu ,  Dindo Mijares ,  Deepak Saxena ,  Sudharani Bodepudi

IPC: A61K8/24 ,  A61Q11/00 ,  C01B25/32 ,  A61K8/27

CPC classification number: A61K6/0017

Abstract: The present invention provides compositions including saturated calcium phosphate (sCaP) solutions, that may be prepared from mixtures of calcium deficient apatite and one or more of sodium fluoride and zinc chloride, or F or Zn ions. The solutions may be prepared from mixtures of calcium compounds and one or more of sodium or potassium phosphates, sodium or potassium fluoride and zinc salts with, for instance, either phosphoric or hydrochloric acids. Such compositions may be useful for increasing occlusion of dentin tubules, decreasing bacterial attachment to dentin tubules, decreasing bacterial growth or colonization on tooth surfaces such as enamel and dentin surfaces including on dentin tubules, increasing resistance to acid dissolution, inhibiting dental caries formation and progression and tooth decay and inhibiting development of tooth hypersensitivity.

Abstract translation: 本发明提供了包括饱和磷酸钙（sCaP）溶液的组合物，其可以由缺钙磷灰石和一种或多种氟化钠和氯化锌或F或Zn离子的混合物制备。 该溶液可以由钙化合物和一种或多种磷酸钠或钾盐，氟化钠或氟化钾和锌盐与例如磷酸或盐酸的混合物制备。 这样的组合物可用于增加牙本质小管的闭塞，减少牙本质小管的细菌附着，减少牙齿表面上的细菌生长或定植，例如包括牙本质小管上的牙釉质和牙本质表面，增加抗酸溶解性，抑制龋齿形成和进展 蛀牙，抑制牙齿过敏发展。

公开(公告)号：US20100136586A1

公开(公告)日：2010-06-03

申请号：US10817102

申请日：2004-04-01

Applicant: Page W. Caufield ,  Deepak Saxena ,  Michael C. Alfano

Inventor： Page W. Caufield ,  Deepak Saxena ,  Michael C. Alfano

IPC: G01N33/569

CPC classification number: G01N1/00 ,  G01N2001/021 ,  G01N2001/022

Abstract: Provided is a method of surveillance for hazardous materials, e.g., chemical, biological and radiological agents. The method comprises assaying a sample derived from materials collected from a sample domain for the presence of a chemical, biological, or radiological agent. The sample domain comprises at least one collection point from which the materials are collected in a pre-existing operation unrelated to surveillance.

Abstract translation: 提供了用于危险材料的监测方法，例如化学，生物和放射剂。 该方法包括测定衍生自从样品区域收集的材料的样品，用于存在化学，生物或放射性试剂。 样本域包括至少一个收集点，在该收集点中，物料在与监视无关的预先存在的操作中被收集。

公开(公告)号：US09005587B2

公开(公告)日：2015-04-14

申请号：US13433794

申请日：2012-03-29

Applicant: Racquel Z. LeGeros ,  Haijing Gu ,  Dindo Mijares ,  Deepak Saxena ,  Sudharani Bodepudi

Inventor： Racquel Z. LeGeros ,  Haijing Gu ,  Dindo Mijares ,  Deepak Saxena ,  Sudharani Bodepudi

IPC: A61Q11/00 ,  A61K8/21 ,  A61K8/27 ,  A61K8/24 ,  A61K6/033 ,  A61K6/04 ,  A61K6/00

CPC classification number: A61K6/0017

Abstract: The present invention provides compositions including saturated calcium phosphate (sCaP) solutions, that may be prepared from mixtures of calcium deficient apatite and one or more of sodium fluoride and zinc chloride, or F or Zn ions. The solutions may be prepared from mixtures of calcium compounds and one or more of sodium or potassium phosphates, sodium or potassium fluoride and zinc salts with, for instance, either phosphoric or hydrochloric acids. Such compositions may be useful for increasing occlusion of dentin tubules, decreasing bacterial attachment to dentin tubules, decreasing bacterial growth or colonization on tooth surfaces such as enamel and dentin surfaces including on dentin tubules, increasing resistance to acid dissolution, inhibiting dental caries formation and progression and tooth decay and inhibiting development of tooth hypersensitivity.

Abstract translation: 本发明提供了包括饱和磷酸钙（sCaP）溶液的组合物，其可以由缺钙磷灰石和一种或多种氟化钠和氯化锌或F或Zn离子的混合物制备。 该溶液可以由钙化合物和一种或多种磷酸钠或钾盐，氟化钠或氟化钾和锌盐与例如磷酸或盐酸的混合物制备。 这样的组合物可用于增加牙本质小管的闭塞，减少牙本质小管的细菌附着，减少牙齿表面上的细菌生长或定植，例如包括牙本质小管上的牙釉质和牙本质表面，增加抗酸溶解性，抑制龋齿形成和进展 蛀牙，抑制牙齿过敏发展。

公开(公告)号：US20090305252A1

公开(公告)日：2009-12-10

申请号：US12156955

申请日：2008-06-04

Applicant: Yihong Li ,  Page W. Caufield ,  Deepak Saxena ,  Zhou Chen

Inventor： Yihong Li ,  Page W. Caufield ,  Deepak Saxena ,  Zhou Chen

IPC: C12Q1/68 ,  C07H21/00

CPC classification number: C12Q1/689 ,  C12Q2600/16

Abstract: Dental caries is a polymicrobial infectious disease. Of the hundreds of bacteria present in the biofilms coating teeth, the Streptococcus mutans (S. mutans) remain strongly linked to caries and dental disease. Streptococcus sanguinis (S. sanguinis) may serve a protective or antagonistic role against the cariogenic bacterium S. mutans. In the present invention, exemplary sets of species-specific PCR primers are provided for the identification and quantification of S. mutans and of S. sanguinis in clinical samples, including the simultaneous and sensitive analysis of both bacterial species. Assays, kits and methods for determining the presence and amount of S. mutans and/or S. sanguinis are provided. Oligonucleotide probes and primers for use in the assays, kits and methods are described. Assays and methods for determining and evaluating an individual's oral bacteria, risk for caries, and effects of prevention and treatment modalities, are provided.

Abstract translation: 牙龋是一种多微生物感染性疾病。 在生物膜涂覆牙齿中存在的数百种细菌中，变形链球菌（变形链球菌）与龋齿和牙齿疾病密切相关。 血清链球菌（S.sanguinis）可能对致龋菌细菌变形链球菌起保护作用或拮抗作用。 在本发明中，提供了典型的物种特异性PCR引物组用于在临床样品中鉴定和定量变形链球菌和血清芽孢杆菌，包括对这两种细菌物种的同时和敏感的分析。 提供了用于确定变形链球菌和/或血清血友病的存在和量的测定，试剂盒和方法。 描述了用于测定，试剂盒和方法的寡核苷酸探针和引物。 提供了确定和评估个人口腔细菌，龋风险和预防和治疗方式的影响的方法和方法。