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公开(公告)号：US5849509A
公开(公告)日：1998-12-15
申请号：US488036
申请日：1995-06-07
IPC分类号： G01N33/53 , A61K31/70 , A61K39/395 , A61K48/00 , A61P35/00 , C07K14/435 , C07K14/47 , C07K14/82 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/08 , C12Q1/68 , G01N33/574 , G01N33/577
CPC分类号： G01N33/57434 , C07K14/47 , Y10S436/813
摘要： Nuclear matrix proteins (NMP) which are characterized by a defined expression in tissue are provided. These NMPs are useful markers in diagnosing and monitoring the stage of malignancy of a cell. Also provided are substantially purified polypeptides and nucleotide sequences encoding the NMPs of the invention.
摘要翻译： 提供以组织中定义的表达为特征的核基质蛋白（NMP）。 这些NMP是诊断和监测细胞恶性肿瘤阶段的有用标志物。 还提供了基本纯化的多肽和编码本发明的NMP的核苷酸序列。
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2.发明授权Method for detecting prostate cancer using a reagent which binds prostate cancer-1 protein 失效使用结合前列腺癌1蛋白的试剂检测前列腺癌的方法
公开(公告)号：US5824490A
公开(公告)日：1998-10-20
申请号：US455558
申请日：1995-05-31
IPC分类号： G01N33/53 , A61K31/70 , A61K39/395 , A61K48/00 , A61P35/00 , C07K14/435 , C07K14/47 , C07K14/82 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/08 , C12Q1/68 , G01N33/574 , G01N33/577
CPC分类号： G01N33/57434 , C07K14/47 , Y10S436/813
摘要： Nuclear matrix proteins (NMP) which are characterized by a defined expression in tissue are provided. Also provided is an in vitro method for detecting prostate cancer in a sample employing a reagent that reacts with the NMP designated PC-1 (prostate cancer-1).
摘要翻译： 提供以组织中定义的表达为特征的核基质蛋白（NMP）。 还提供了使用与指定为PC-1的NMP（前列腺癌-1）反应的试剂的样品中检测前列腺癌的体外方法。
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公开(公告)号：US06933114B2
公开(公告)日：2005-08-23
申请号：US09978969
申请日：2001-10-16
申请人： Shawn E. Lupold , Yun Lin , Brian J. Hicke , Donald S. Coffey
发明人： Shawn E. Lupold , Yun Lin , Brian J. Hicke , Donald S. Coffey
IPC分类号： C12N15/09 , A61K47/48 , A61K51/00 , A61P35/00 , C07K14/705 , C07K17/02 , C12N15/115 , C12Q1/68 , C07H21/04 , C12N14/00
CPC分类号： C12Q1/6886 , C07K14/705 , C12N15/115 , C12N2310/322
摘要： Methods are provided for generating nucleic acid ligands of Prostate Specific Membrane Antigen (PSMA). The methods of the invention use the SELEX method for the isolation of nucleic acid ligands. The invention also includes nucleic acid ligands to PSMA, and methods and compositions for the treatment and diagnosis of disease using the nucleic acid ligands.
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公开(公告)号：US6030793A
公开(公告)日：2000-02-29
申请号：US256428
申请日：1999-02-23
IPC分类号： G01N33/53 , A61K31/70 , A61K39/395 , A61K48/00 , A61P35/00 , C07K14/435 , C07K14/47 , C07K14/82 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/08 , C12Q1/68 , G01N33/574 , G01N33/577 , C07K16/18 , C12Q1/00
CPC分类号： G01N33/57434 , C07K14/47 , Y10S436/813
摘要： Nuclear matrix proteins (NMP) which are characterized by a defined expression in tissue are provided. These NMPs are useful markers in diagnosing and monitoring the stage of malignancy of a cell and treating cell proliferative disorders associated with the NMP. Also provided are substantially purified polypeptides and nucleotide sequences encoding the NMPs of the invention.
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公开(公告)号：US5874539A
公开(公告)日：1999-02-23
申请号：US459023
申请日：1995-06-02
IPC分类号： G01N33/53 , A61K31/70 , A61K39/395 , A61K48/00 , A61P35/00 , C07K14/435 , C07K14/47 , C07K14/82 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/08 , C12Q1/68 , G01N33/574 , G01N33/577 , C07K16/18
CPC分类号： G01N33/57434 , C07K14/47 , Y10S436/813
摘要： Antibodies directed to nuclear matrix proteins (NMP) are provided. Such antibodies are useful markers in diagnosing and monitoring the stage of malignancy of a cell.
摘要翻译： 提供了针对核基质蛋白（NMP）的抗体。 这些抗体是诊断和监测细胞恶性肿瘤阶段的有用标志物。
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