Methods of stimulating ErbB4 receptor phosphorylation
    1.
    发明授权
    Methods of stimulating ErbB4 receptor phosphorylation 有权
    刺激ErbB4受体磷酸化的方法

    公开(公告)号:US07846453B2

    公开(公告)日:2010-12-07

    申请号:US11454635

    申请日:2006-06-15

    摘要: The invention concerns a novel neuregulin related ligand (NRG3) including fragments and variants thereof, as new members of the neuregulin family of compounds. The invention also concerns methods and means for producing NRG3. The native polypeptides of the invention are characterized by containing an extracellular domain including an EGF-like domain, a transmembrane domain and a cytoplasmic domain. Isolated nucleotide sequences encoding such polypeptides, expression vectors containing the nucleotide sequences, recombinant host cells transformed with the vectors, and methods for the recombinant production for the novel NRG3s are also within the scope of the invention.

    摘要翻译: 本发明涉及新型神经调节蛋白相关配体(NRG3),其包括其片段和变体,作为化合物神经调节蛋白家族的新成员。 本发明还涉及生产NRG3的方法和手段。 本发明的天然多肽的特征在于含有包括EGF样结构域,跨膜结构域和细胞质结构域的细胞外结构域。 编码这种多肽的分离的核苷酸序列,含有核苷酸序列的表达载体,用载体转化的重组宿主细胞,以及用于新型NRG3重组生产的方法也在本发明的范围内。

    ErbB4 receptor-specific neuregulin related ligands and uses therefor
    6.
    发明申请
    ErbB4 receptor-specific neuregulin related ligands and uses therefor 有权
    ErbB4受体特异性神经调节蛋白相关配体及其用途

    公开(公告)号:US20050048622A1

    公开(公告)日:2005-03-03

    申请号:US10944116

    申请日:2004-09-17

    摘要: The invention concerns a novel neuregulin related ligand (NRG3) including fragments and variants thereof, as new members of the neuregulin family of compounds. The invention also concerns methods and means for producing NRG3. The native polypeptides of the invention are characterized by containing an extracellular domain including an EGF-like domain, a transmembrane domain and a cytoplasmic domain. Isolated nucleotide sequences encoding such polypeptides, expression vectors containing the nucleotide sequences, recombinant host cells transformed with the vectors, and methods for the recombinant production for the novel NRG3s are also within the scope of the invention.

    摘要翻译: 本发明涉及新型神经调节蛋白相关配体(NRG3),其包括其片段和变体,作为化合物神经调节蛋白家族的新成员。 本发明还涉及生产NRG3的方法和手段。 本发明的天然多肽的特征在于含有包括EGF样结构域,跨膜结构域和细胞质结构域的细胞外结构域。 编码这种多肽的分离的核苷酸序列,含有核苷酸序列的表达载体,用载体转化的重组宿主细胞,以及用于新型NRG3重组生产的方法也在本发明的范围内。

    Type I interferons
    7.
    发明授权
    Type I interferons 失效
    I型干扰素

    公开(公告)号:US06299877B1

    公开(公告)日:2001-10-09

    申请号:US09206935

    申请日:1998-12-07

    IPC分类号: A61K39395

    摘要: The invention concerns a novel human interferon-&egr;, originally designated PRO655, and its variants and derivatives. The novel interferon is related to but distinct from members of the IFN-&agr; family and from IFNs-&bgr; and -&ggr;. Nucleic acid encoding the novel polypeptide, and methods and means for their recombinant production are also included.

    摘要翻译: 本发明涉及一种新型的人干扰素-ε,最初命名为PRO655,其变体和衍生物。 该新型干扰素与IFN-α家族的成员和IFN-β和γ的成员相关但不同。 还包括编码新型多肽的核酸及其重组生产的方法和手段。

    ErbB4 receptor-specific neuregulin related ligand antibodies and uses therefor
    10.
    发明授权
    ErbB4 receptor-specific neuregulin related ligand antibodies and uses therefor 失效
    ErbB4受体特异性神经调节蛋白相关配体抗体及其用途

    公开(公告)号:US06252051B1

    公开(公告)日:2001-06-26

    申请号:US09126121

    申请日:1998-07-30

    IPC分类号: C07K1600

    摘要: The invention concerns a novel neuregulin related ligand (NRG3) including fragments and variants thereof, as new members of the neuregulin family of compounds. The invention also concerns methods and means for producing NRG3. The native polypeptides of the invention are characterized by containing an extracellular domain including an EGF-like domain, a transmembrane domain and a cytoplasmic domain. Isolated nucleotide sequences encoding such polypeptides, expression vectors containing the nucleotide sequences, recombinant host cells transformed with the vectors, and methods for the recombinant production for the novel NRG3s are also within the scope of the invention.

    摘要翻译: 本发明涉及新型神经调节蛋白相关配体(NRG3),其包括其片段和变体,作为化合物神经调节蛋白家族的新成员。 本发明还涉及生产NRG3的方法和手段。 本发明的天然多肽的特征在于含有包括EGF样结构域,跨膜结构域和细胞质结构域的细胞外结构域。 编码这种多肽的分离的核苷酸序列,含有核苷酸序列的表达载体,用载体转化的重组宿主细胞,以及用于新型NRG3重组生产的方法也在本发明的范围内。