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公开(公告)号：US20110110970A1
公开(公告)日：2011-05-12
申请号：US12824835
申请日：2010-06-28
IPC分类号： A61K39/385 , A61P37/02
CPC分类号： A61K39/21 , A61K39/00 , A61K39/12 , A61K2039/53 , A61K2039/57 , C07H21/04 , C07K14/005 , C07K14/70596 , C07K2319/00 , C07K2319/03 , C07K2319/06 , C07K2319/40 , C12N7/00 , C12N15/62 , C12N15/86 , C12N2740/16234 , C12N2750/14143
摘要： The invention provides chimeric proteins and nucleic acids encoding these which can be used to generate vaccines against selected antigens. In one aspect, a chimeric protein comprises an antigen sequence and a domain for trafficking the protein to an endosomal compartment, irrespective of whether the antigen is derived from a membrane or non-membrane protein. In one preferred aspect, the trafficking domain comprises a lumenal domain of a LAMP polypeptide. Alternatively, or additionally, the chimeric protein comprises a trafficking domain of an endocytic receptor (e.g., such as DEC-205 or gp200-MR6). The vaccines (DNA, RNA or protein) can be used to modulate or enhance an immune response against any kind of antigen. In one preferred aspect, the invention provides a method for treating a patient with cancer by providing a chimeric protein comprising a cancer-specific antigen or a nucleic acid encoding the protein to the patient.
摘要翻译： 本发明提供嵌合蛋白质和编码这些蛋白质的核酸，其可用于产生针对所选抗原的疫苗。 在一个方面，嵌合蛋白包括抗原序列和用于将蛋白质运送到内体室的结构域，而不管抗原是源自膜还是非膜蛋白。 在一个优选的方面，所述贩运结构域包含LAMP多肽的内腔结构域。 或者或另外，嵌合蛋白质包含内吞受体（例如DEC-205或gp200-MR6）的贩运结构域。 疫苗（DNA，RNA或蛋白质）可用于调节或增强针对任何种类抗原的免疫应答。 在一个优选的方面，本发明提供了一种通过向患者提供包含癌特异性抗原或编码该蛋白的核酸的嵌合蛋白来治疗癌症患者的方法。
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公开(公告)号：US08445660B2
公开(公告)日：2013-05-21
申请号：US12824835
申请日：2010-06-28
CPC分类号： A61K39/21 , A61K39/00 , A61K39/12 , A61K2039/53 , A61K2039/57 , C07H21/04 , C07K14/005 , C07K14/70596 , C07K2319/00 , C07K2319/03 , C07K2319/06 , C07K2319/40 , C12N7/00 , C12N15/62 , C12N15/86 , C12N2740/16234 , C12N2750/14143
摘要： The invention provides chimeric proteins and nucleic acids encoding these which can be used to generate vaccines against selected antigens. In one aspect, a chimeric protein comprises an antigen sequence and a domain for trafficking the protein to an endosomal compartment, irrespective of whether the antigen is derived from a membrane or non-membrane protein. In one preferred aspect, the trafficking domain comprises a lumenal domain of a LAMP polypeptide. Alternatively, or additionally, the chimeric protein comprises a trafficking domain of an endocytic receptor (e.g., such as DEC-205 or gp200-MR6). The vaccines (DNA, RNA or protein) can be used to modulate or enhance an immune response against any kind of antigen. In one preferred aspect, the invention provides a method for treating a patient with cancer by providing a chimeric protein comprising a cancer-specific antigen or a nucleic acid encoding the protein to the patient.
摘要翻译： 本发明提供嵌合蛋白质和编码这些蛋白质的核酸，其可用于产生针对所选抗原的疫苗。 在一个方面，嵌合蛋白包括抗原序列和用于将蛋白质运送到内体室的结构域，而不管抗原是源自膜还是非膜蛋白。 在一个优选的方面，所述贩运结构域包含LAMP多肽的内腔结构域。 或者或另外，嵌合蛋白质包含内吞受体（例如DEC-205或gp200-MR6）的贩运结构域。 疫苗（DNA，RNA或蛋白质）可用于调节或增强针对任何种类抗原的免疫应答。 在一个优选的方面，本发明提供了一种通过向患者提供包含癌特异性抗原或编码该蛋白的核酸的嵌合蛋白来治疗癌症患者的方法。
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公开(公告)号：US08318173B2
公开(公告)日：2012-11-27
申请号：US10474371
申请日：2002-04-05
CPC分类号： A61K39/21 , A61K39/00 , A61K39/12 , A61K2039/53 , A61K2039/57 , C07H21/04 , C07K14/005 , C07K14/70596 , C07K2319/00 , C07K2319/03 , C07K2319/06 , C07K2319/40 , C12N7/00 , C12N15/62 , C12N15/86 , C12N2740/16234 , C12N2750/14143
摘要： The invention provides chimeric proteins and nucleic acids encoding these which can be used to generate vaccines against selected antigens. In one aspect, a chimeric protein comprises an antigen sequence and a domain for trafficking the protein to an endosomal compartment, irrespective of whether the antigen is derived from a membrane or non-membrane protein. In one preferred aspect, the trafficking domain comprises a lumenal domain of a LAMP polypeptide. Alternatively, or additionally, the chimeric protein comprises a trafficking domain of an endocytic receptor (e.g., such as DEC-205 or gp200-MR6). The vaccines (DNA, RNA or protein) can be used to modulate or enhance an immune response against any kind of antigen. In one preferred aspect, the invention provides a method for treating a patient with cancer by providing a chimeric protein comprising a cancer-specific antigen or a nucleic acid encoding the protein to the patient.
摘要翻译： 本发明提供嵌合蛋白质和编码这些蛋白质的核酸，其可用于产生针对所选抗原的疫苗。 在一个方面，嵌合蛋白包括抗原序列和用于将蛋白质运送到内体室的结构域，而不管抗原是源自膜还是非膜蛋白。 在一个优选的方面，所述贩运结构域包含LAMP多肽的内腔结构域。 或者或另外，嵌合蛋白质包含内吞受体（例如DEC-205或gp200-MR6）的贩运结构域。 疫苗（DNA，RNA或蛋白质）可用于调节或增强针对任何种类抗原的免疫应答。 在一个优选的方面，本发明提供了一种通过向患者提供包含癌特异性抗原或编码该蛋白的核酸的嵌合蛋白来治疗癌症患者的方法。
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