公开(公告)号：US09903874B2

公开(公告)日：2018-02-27

申请号：US14913879

申请日：2014-08-18

Applicant: Fujita Health University

Inventor： Yoshikazu Kurosawa ,  Nobuko Ohshima

IPC: G01N33/68 ,  G01N33/569 ,  C07K16/10

CPC classification number: G01N33/686 ,  C07K16/1018 ,  C07K2317/21 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/76 ,  G01N33/56983 ,  G01N2333/11

Abstract: Provided is a method of providing an effective means as a countermeasure for handling a pandemic of an influenza virus. The resistance to a type A influenza virus is determined using, as an indicator, the presence or otherwise of antibodies using the VH1-69 gene in a biological sample originating from a subject.

公开(公告)号：US20160152692A1

公开(公告)日：2016-06-02

申请号：US15017246

申请日：2016-02-05

Applicant: Fujita Health University ,  The Research Foundation for Microbial Diseases of

Inventor： Yoshikazu KUROSAWA ,  Yoshitaka IBA ,  Nobuko OHSHIMA ,  Yoshinobu OKUNO

IPC: C07K16/10

CPC classification number: C07K16/1018 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2317/76 ,  C07K2319/00

Abstract: Provided is an anti-influenza virus antibody that exhibits neutralizing activity beyond the barrier of the two groups of influenza viruses categorized according to the conservativeness of hemagglutinin amino acids, a method of producing the same, and a test method for determining whether the subject carries the neutralizing antibody.

Abstract translation: 本发明提供了抗血清病毒抗体，其表现出根据血凝素氨基酸的保守性分类的两组流感病毒的屏障之外的中和活性，其生产方法，以及用于确定受试者是否携带 中和抗体。

公开(公告)号：US20150178916A1

公开(公告)日：2015-06-25

申请号：US14574614

申请日：2014-12-18

Applicant: Toshiba Medical Systems Corporation ,  Fujita Health University

Inventor： Takuya SAKAGUCHI ,  Takashi Ichihara

IPC: G06T7/00 ,  G06T5/00 ,  A61B6/00

CPC classification number: G06T5/00 ,  A61B6/481 ,  A61B6/504 ,  A61B6/5205 ,  A61B6/5258 ,  A61B6/583 ,  G06T5/007 ,  G06T2207/10116

Abstract: According to one embodiment, a medical image processing apparatus includes an image acquisition part and a data processing part. The image acquisition part is configured to obtain X-ray image data of an object including not less than three phantoms whose X-ray absorption factors are different from each other. The data processing part is configured to generate corrected X-ray image data of the object by correcting the obtained X-ray image data or other X-ray image data. The obtained X-ray image data or the other X-ray image data are corrected using a nonlinear function obtained based on pixel values of the obtained X-ray image data. The pixel values correspond to the phantoms.

Abstract translation: 根据一个实施例，医学图像处理装置包括图像获取部分和数据处理部分。 图像获取部被配置为获得包含X射线吸收系数彼此不同的3个以上的幻影的物体的X射线图像数据。 数据处理部被配置为通过校正所获得的X射线图像数据或其他X射线图像数据来生成对象的校正的X射线图像数据。 使用基于所获得的X射线图像数据的像素值获得的非线性函数来校正所获得的X射线图像数据或其他X射线图像数据。 像素值对应于幻影。

公开(公告)号：US20140350393A1

公开(公告)日：2014-11-27

申请号：US14453665

申请日：2014-08-07

Applicant: Fujita Health University ,  Toshiba Medical Systems Corporation

Inventor： Takashi Ichihara ,  Takuya Sakaguchi

IPC: A61B5/0295 ,  A61B6/03 ,  A61B5/029

CPC classification number: A61B5/0295 ,  A61B5/029 ,  A61B6/03 ,  A61B6/032 ,  A61B6/4441 ,  A61B6/463 ,  A61B6/469 ,  A61B6/481 ,  A61B6/503 ,  A61B6/504 ,  A61B6/507 ,  A61B6/5217 ,  G06T7/0012 ,  G06T2207/30104

Abstract: According to one embodiment, a medical image diagnostic apparatus includes a storage unit, a blood flow information generation unit and a blood flow inhibition index generation unit. The storage unit stores volume data or data of a series of images regarding an organ of an object. The blood flow information generation unit generates, based on the volume data or the data of the series of images, first blood flow information of a first region and second blood flow information of a second region different from the first region. The blood flow inhibition index generation unit generates, based on the first blood flow information and the second blood flow information, a blood flow inhibition index representing a degree of inhibition of a blood flow in a blood vessel regarding the first region or the second region.

Abstract translation: 根据一个实施例，医疗图像诊断装置包括存储单元，血流信息生成单元和血流阻止指标生成单元。 存储单元存储关于对象的器官的一系列图像的体数据或数据。 血流信息生成单元基于一系列图像的体积数据或数据生成与第一区域不同的第一区域的第一血流信息和第二区域的第二血流信息。 血流抑制指标生成单元基于第一血流信息和第二血流信息，生成表示血管内血流关于第一区域或第二区域的抑制程度的血流抑制指标。

公开(公告)号：US20140086927A1

公开(公告)日：2014-03-27

申请号：US14035495

申请日：2013-09-24

Applicant: Fujita Health University ,  The Research Foundation for Microbial Diseases of Osaka University ,  Osaka University

Inventor： Yoshikazu Kurosawa ,  Yoshitaka Iba ,  Nobuko Ohshima ,  Shigeyuki Yokoyama ,  Mikako Shirouzu ,  Yoshifumi Fujii ,  Tomomi Sumida ,  Kazuyoshi Ikuta ,  Shota Nakamura ,  Norihito Kawashita ,  Mitsuhiro Nishimura ,  Akifumi Yamashita ,  Yoshinobu Okuno ,  Ritsuko Kubota-Koketsu ,  Masahiro Okubo

IPC: C07K16/10 ,  G01N33/569

CPC classification number: C07K16/1018 ,  C07K2299/00 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/76 ,  G01N33/56983 ,  G01N2333/11 ,  G16B15/00 ,  G16C20/50

Abstract: Antibodies (Abs) play roles in protection against influenza. Neutralizing Abs either inhibit the binding of hemagglutinin (HA) to cellular receptors or prevent the conformational change of HA induced by low pH. The former Ab binds to the regions near the sialic acid-binding pocket on the globular head formed by HA1 and generally shows narrow strain specificity. The latter Ab binds to the stem region formed mainly by HA2 and shows broad strain specificity. We isolated a broadly neutralizing Ab against H3N2 viruses. X-ray analysis of the HA/Ab complex indicated that the Ab binds to the valley formed by two neighboring HA monomers at the side of the globular head. The Ab shows neutralizing activity by preventing the conformational change of HA induced at low pH.

Abstract translation: 抗体（Abs）在防止流行性感冒方面发挥作用。 中和抗体可抑制血细胞凝集素（HA）与细胞受体的结合，或阻止由低pH引起的HA的构象变化。 前者Ab与HA1形成的球形头上唾液酸结合口附近的区域结合，通常表现出狭窄的应变特异性。 后者Ab结合主要由HA2形成的茎区，并显示出广泛的应变特异性。 我们分离出一种广泛中和的Ab针对H3N2病毒。 HA / Ab复合物的X射线分析表明，Ab与球状头部侧面的两个相邻的HA单体形成的谷结合。 Ab通过防止在低pH下诱导的HA的构象变化来显示中和活性。

公开(公告)号：US10285604B2

公开(公告)日：2019-05-14

申请号：US14453665

申请日：2014-08-07

Applicant: Fujita Health University ,  Toshiba Medical Systems Corporation

Inventor： Takashi Ichihara ,  Takuya Sakaguchi

IPC: A61B6/00 ,  A61B5/0295 ,  G06T7/00 ,  A61B5/029 ,  A61B6/03

Abstract: According to one embodiment, a medical image diagnostic apparatus includes a storage unit, a blood flow information generation unit and a blood flow inhibition index generation unit. The storage unit stores volume data or data of a series of images regarding an organ of an object. The blood flow information generation unit generates, based on the volume data or the data of the series of images, first blood flow information of a first region and second blood flow information of a second region different from the first region. The blood flow inhibition index generation unit generates, based on the first blood flow information and the second blood flow information, a blood flow inhibition index representing a degree of inhibition of a blood flow in a blood vessel regarding the first region or the second region.

公开(公告)号：US09414751B2

公开(公告)日：2016-08-16

申请号：US13863874

申请日：2013-04-16

Applicant: FUJITA HEALTH UNIVERSITY ,  Toshiba Medical Systems Corporation

Inventor： Takashi Ichihara ,  Masahiro Ozaki

IPC: A61B5/05 ,  A61B5/02 ,  A61B6/00 ,  A61B6/03 ,  A61B6/02

CPC classification number: A61B5/02 ,  A61B6/027 ,  A61B6/032 ,  A61B6/481 ,  A61B6/503 ,  A61B6/507 ,  A61B6/5235

Abstract: An image processing apparatus according to an embodiment includes an acquiring unit, a correcting unit, and a perfusion image creating unit. The acquiring unit obtains a pixel value of a myocardium tissue and an arterial blood before a contrast agent injected in a second contrast examination arrives at a cardiac of a subject when myocardium perfusion data is created, by performing the second contrast examination that captures a second medical image group including the cardiac of the subject who is given an injection of a contrast agent again after a first contrast examination that captures a first medical image group. The correcting unit corrects contrast agent concentrations of an arterial blood and a myocardium tissue in the second medical image group using acquired each pixel value. The perfusion image creating unit computes the myocardium perfusion data in the second contrast examination based on the corrected contrast agent concentrations.

Abstract translation: 根据实施例的图像处理装置包括获取单元，校正单元和灌注图像创建单元。 在创建心肌灌注数据之前，获取单元获得心脏组织和动脉血液的像素值，然后在第二次造影检查中注射的造影剂到达受试者的心脏时，通过进行第二次对照检查 图像组包括在拍摄第一医学图像组的第一对比度检查之后再次注射造影剂的受试者的心脏。 校正单元使用获取的每个像素值来校正第二医用图像组中的动脉血和心肌组织的造影剂浓度。 灌注图像创建单元基于校正的造影剂浓度计算第二次对比度检查中的心肌灌注数据。

公开(公告)号：US09388249B2

公开(公告)日：2016-07-12

申请号：US14265416

申请日：2014-04-30

Applicant: Fujita Health University

Inventor： Atsushi Sugioka ,  Gene Kurosawa ,  Mariko Sumitomo ,  Yoshikazu Kurosawa

IPC: A61K39/395 ,  C07K16/30 ,  C07K16/00 ,  C07K16/28 ,  C07K16/32 ,  C07K16/40 ,  C12N15/113 ,  G01N33/574 ,  G01N33/68

CPC classification number: C07K16/30 ,  C07K16/005 ,  C07K16/28 ,  C07K16/2803 ,  C07K16/2863 ,  C07K16/2896 ,  C07K16/303 ,  C07K16/32 ,  C07K16/40 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  C12N15/1138 ,  C12N2310/14 ,  G01N33/57492 ,  G01N33/6854

Abstract: The present invention relates to an isolated antibody against HER1, an isolated antibody against CD147, an isolated antibody against CD73, and an isolated antibody against EpCAM; reagents and compositions including said antibodies; and uses of said reagents, compositions, and antibodies. The present invention also relates to nucleic acids and vectors expressing said antibodies. The invention further relates to transformants comprising said nucleic acids or vectors.

Abstract translation: 本发明涉及针对HER1的分离抗体，针对CD147的分离抗体，针对CD73的分离抗体和针对EpCAM的分离抗体; 包括所述抗体的试剂和组合物; 和所述试剂，组合物和抗体的用途。 本发明还涉及表达所述抗体的核酸和载体。 本发明还涉及包含所述核酸或载体的转化体。

公开(公告)号：US09273140B2

公开(公告)日：2016-03-01

申请号：US13891652

申请日：2013-05-10

Applicant: FUJITA HEALTH UNIVERSITY ,  PERSEUS PROTEOMICS INC.

Inventor： Yoshikazu Kurosawa ,  Maiko Kurosawa ,  Gene Kurosawa

IPC: C07K16/30 ,  C12N15/13 ,  C12N15/85 ,  G01N33/68 ,  C07K16/28

CPC classification number: C07K16/30 ,  C07K16/28 ,  C07K2317/622 ,  G01N33/6893

Abstract: To provide a method for detecting cellular DNA damage by specifically recognizing molecules responsive to DNA strand breaks. A method for detecting DNA damage in cells, which comprises administering in vivo, to cells, an antibody against a cell membrane surface antigen that is expressed in cells undergoing DNA strand breaks to a greater extent than in cells not undergoing DNA strand breaks in an environment that causes DNA damage, and analyzing the expression status of the cell membrane surface antigen.

Abstract translation: 提供通过特异性识别对DNA链断裂有反应的分子来检测细胞DNA损伤的方法。 一种用于检测细胞中DNA损伤的方法，其包括在体内向细胞施用针对细胞膜表面抗原的抗体，其在经历DNA链断裂的细胞中表达的程度大于在环境中不经历DNA链断裂的细胞中 导致DNA损伤，并分析细胞膜表面抗原的表达状态。

公开(公告)号：US09061108B2

公开(公告)日：2015-06-23

申请号：US14060074

申请日：2013-10-22

Applicant: Fujita Health University ,  Kaneka Corporation

Inventor： Nobuya Kitaguchi ,  Kazunori Kawaguchi

IPC: A61M1/38 ,  A61M1/36

CPC classification number: A61M1/3679 ,  G01N2333/4709 ,  G01N2800/2821

Abstract: An object is to provide a material capable of removing Aβ from a body fluid efficiently and use of the material, which are developed for the purpose of establishing a therapeutic or preventive method for Alzheimer's disease. Provided is an amyloid β protein remover, containing a carrier made of any one material selected from the group consisting of cellulose, silica, polyvinyl alcohol, and activated carbon, wherein the carrier does not have an alkyl chain on the surface thereof or has an alkyl chain having 1 to 18 carbon atoms on the surface thereof.

Abstract translation: 目的是提供能够去除A＆bgr的材料; 从体液中有效地利用材料，这些材料是为了建立阿尔茨海默病的治疗或预防方法而开发的。 提供淀粉样蛋白 蛋白质去除剂，其含有由选自纤维素，二氧化硅，聚乙烯醇和活性炭组成的组中的任何一种材料制成的载体，其中载体在其表面上不具有烷基链或具有1至18个的烷基链 碳原子在其表面。