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公开(公告)号：US5175113A
公开(公告)日：1992-12-29
申请号：US550919
申请日：1990-03-29
CPC分类号： C07K14/70539 , C07K16/2833 , G01N33/6893 , A61K38/00 , Y10S436/804
摘要： Substantially pure modified .beta..sub.2 -microglobulin (m.beta..sub.2 m) of the formula I ##STR1## wherein R.sub.1 is 24-amino acid residue, with the sequence Ile-Gln-Arg-Thr-Pro-Lys-Ile-Gln-Val-Tyr-Ser-Arg-His-Pro-Ala-Glu-Asn-Gly-Lys-Ser-Asn-Phe-Leu-Asn, R.sub.2 is a 30-amino acid residue with the sequence Tyr-Val-Ser-Gly-Phe-His-Pro-Ser-Asp-Ile-Glu-Val-Asp-Leu-Leu-Lys-Asn-Gly-Glu-Arg-Ile-Gly-Lys-Val-Glu-His-Ser-Asp-Leu-Ser, R.sub.3 is a 20-amino acid residue with the sequence Trp-Ser-Phe-Tyr-Leu-Leu-Tyr-Tyr-Glu-Phe-Thr-Pro-Thr-Glu-Lys-Asp-Glu-Tyr-Ala, R.sub.4 is a 19-amino acid residue with the sequence Arg-Val-Asn-His-Val-Thr-Leu-Ser-Gln-Pro-Lys-Ile-Val-Lys-Trp-Asp-Arg-Asp-Met, X is Phe, Phe-Ser, or Phe-Ser-Lys, and Y is Asp, Lys-Asp, or Ser-Lys-Asp is disclosed. The presence of the protein in body fluids is a diagnostic and/or prognostic marker for the development of a variety of disorders such as different types of cancer and diseases involving the immune system. Also disclosed are specific anti-m.beta..sub.2 m antibodies used for the detection and quantification of m.beta..sub.2 m.
摘要翻译： 其中R1是24个氨基酸残基的具有Ile-Gln-Arg-Thr-Pro-Lys-Ile-Gln-Val-Tyr序列的基本上纯的经修饰的β2-微球蛋白（mβ2m） -Ser-Arg-His-Pro-Ala-Glu-Asn-Gl y-Lys-Ser-Asn-Phe-Leu-Asn，R2是30-氨基酸残基，具有序列Tyr-Val-Ser-Gly-Phe -His-Pro-Ser-Asp-Ile-Glu-Val-Asp-Leu-Leu-Lys-Asn-Gl y-Glu-Arg-Ile-Gly-Lys-Val-Glu-His-Ser-Asp-Leu- Ser，R3是具有序列Trp-Ser-Phe-Tyr-Leu-Leu-Tyr-Tyr-Glu-Phe-Thr-Pro-Thr-Glu-Lys-Asp-Glu-Tyr- Ala，R4是序列Arg-Val-Asn-His-Val-Thr-Leu-Ser-Gln-Pro-Lys-Ile-Val-Lys-Trp-Asp-Arg-As p- Met，X是Phe，Phe-Ser或Phe-Ser-Lys，Y是Asp，Lys-Asp或Ser-Lys-Asp。 体液中蛋白质的存在是用于发展各种疾病如诊断和/或预后的标志物，例如不同类型的癌症和涉及免疫系统的疾病。 还公开了用于检测和定量m 2 m的特异性抗-mβ2m抗体。
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公开(公告)号：US5051371A
公开(公告)日：1991-09-24
申请号：US3436
申请日：1987-01-15
IPC分类号： C07K14/005 , A61K38/00 , A61K38/16 , A61K39/00 , A61P37/00 , C07K14/00 , C07K14/195 , C07K14/435 , C07K14/74 , C07K16/00 , C07K16/28 , C07K19/00 , C12P21/08 , G01N33/534 , G01N33/569 , G01N33/577 , G01N33/68
CPC分类号： G01N33/6893 , C07K14/70539 , C07K16/2833 , A61K38/00 , C07K2317/34 , Y10S530/811 , Y10S530/812 , Y10S530/864
摘要： Substantially pure modified .beta..sub.2 -microglobulin (m.beta..sub.2 m) of the formula I ##STR1## wherein R.sub.1 is 24-amino acid residue, with the sequence Ile-Gln-Arg-Thr-Pro-Lys-Ile-Gln-Val-Tyr-Ser-Arg-His-Pro-Ala-Glu-Asn-Gly-Lys-Ser-Asn-Phe-Leu-Asn, R.sub.2 is a 30-amino acid residue with the sequence Tyr-Val-Ser-Gly-Phe-His-Pro-Ser-Asp-Ile-Glu-Val-Asp-Leu-Leu-Lys-Asn-Gly-Glu-Arg-Ile-Gly-Lys-Val-Glu-His-Ser-Asp-Leu-Ser, R.sub.3 is a 20-amino acid residue with the sequence Trp-Ser-Phe-Tyr-Leu-Leu-Tyr-Tyr-Glu-Phe-Thr-Pro-Thr-Glu-Lys-Asp-Glu-Tyr-Ala, R.sub.4 is a 19-amino acid residue with the sequence Arg-Val-Asn-His-Val-Thr-Leu-Ser-Gln-Pro-Lys-Ile-Val-Lys-Trp-Asp-Arg-Asp-Met, X is Phe, Phe-Ser, or Phe-Ser-Lys, and Y is Asp, Lys-Asp, or Ser-Lys-Asp is disclosed. The presence of the protein in body fluids is a diagnostic and/or prognostic marker for the development of a variety of disorders such as different types of cancer and diseases involving the immune system. Also disclosed are specific anti-m.beta..sub.2 m antibodies used for the detection and quantification of m.beta..sub.2 m.
摘要翻译： 具有Ile-Gln-Arg-Thr-Pro-Lys-Ile-Gln-Val-I的序列的基本上纯的经修饰的β2-微球蛋白（mβ2m），其中R1是24-氨基酸残基， Tyr-Ser-Arg-His-Pro-Ala-Glu-Asn-Gl y-Lys-Ser-Asn-Phe-Leu-Asn，R2是具有序列Tyr-Val-Ser-Gly- Phe-His-Pro-Ser-Asp-Ile-Glu-Val-Asp-Leu-Leu-Lys-Asn-Gl y-Glu-Arg-Ile-Gly-Lys-Val-Glu-His-Ser-Asp-Leu -Ser，R3是具有序列Trp-Ser-Phe-Tyr-Leu-Leu-Tyr-Tyr-Glu-Phe-Thr-Pro-Thr-Glu-Lys-Asp-Glu-Tyr的20个氨基酸残基 -Ala，R4是具有序列Arg-Val-Asn-His-Val-Thr-Leu-Ser-Gln-Pro-Lys-Ile-Val-Lys-Trp-Asp-Arg-Asp的19个氨基酸残基 -Met，X是Phe，Phe-Ser或Phe-Ser-Lys，Y是Asp，Lys-Asp或Ser-Lys-Asp。 体液中蛋白质的存在是用于发展各种疾病如诊断和/或预后的标志物，例如不同类型的癌症和涉及免疫系统的疾病。 还公开了用于检测和定量m 2 m的特异性抗-mβ2m抗体。
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