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公开(公告)号：US20240262897A1
公开(公告)日：2024-08-08
申请号：US17796661
申请日：2021-01-12
发明人： Alexandre Bezerra Conde FIGUEIREDO , Marcio Lourenco RODRIGUES , Fernando de Paiva CONTE , Fernanda Lopes FONSECA , Marcia ARISSAWA
IPC分类号： C07K16/14
CPC分类号： C07K16/14 , C07K2317/24
摘要： Present invention provides monoclonal antibody against chitin oligomer through hybridoma technique. Antibodies abovementioned can be used as tools to fungal infection diagnostic and treatment. Pharmaceutical compositions and fungal infection treatment kits are also disclosed, including antibodies abovementioned. Moreover, fungal infection diagnostic method is also disclosed, using antibodies abovementioned and their use in drug preparation to treat fungal infections.
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公开(公告)号：US20240052039A1
公开(公告)日：2024-02-15
申请号：US18021566
申请日：2021-05-26
发明人： Vinicius Cotta de ALMEIDA , Beatriz CHAVES , Carolina Lessa AQUINO , João Hermínio Martins DA SILVA , Marco Alberto MEDEIROS , Wilson SAVINO , Ingo RIEDERER
CPC分类号： C07K16/2842 , G01N33/6896 , G01N2800/52 , G01N2800/285 , C07K2317/622 , C07K2317/76
摘要： The present invention relates to a protein of the scFv type in which said protein comprises a first polypeptide chain and a second polypeptide chain joined by a ligand, having the formula as follows: (VH domain)-(ligand)-(VL domain). The present invention further relates to a polynucleotide comprising the nucleotide sequence shown in SEQ ID NO: 1; to a vector comprising the polynucleotide as defined above; to the host cell comprising the vector as previously defined; and the composition comprising the aforementioned protein and a pharmaceutically acceptable excipient. The present invention further relates to a method for treating a disease or condition that results directly or indirectly from α4β1 integrin activity. The present invention further relates to an in vitro method for prognosing multiple sclerosis. The present invention further relates to the use of the previously defined protein or composition in the manufacture of a drug for the treatment of multiple sclerosis.
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公开(公告)号：US20240016826A1
公开(公告)日：2024-01-18
申请号：US18035987
申请日：2021-11-08
发明人： Ana Lúcia Teles RABELLO , Jorge Carlos SANTOS DA COSTA , Dinalva BRITO DE QUEIROZ , Eliane de Morais TEIXEIRA
IPC分类号： A61K31/7036 , A61K31/7048 , A61K31/138 , A61K9/107 , A61K9/00 , A61P33/02 , A61K31/29
CPC分类号： A61K31/7036 , A61K31/7048 , A61K31/138 , A61K9/1075 , A61K9/0014 , A61P33/02 , A61K31/29
摘要： The drugs available for the treatment of cutaneous leishmaniasis have unsatisfactory efficacy, frequent and serious adverse effects, and require long treatment regimens. Thus, the search for new treatment alternatives for cutaneous leishmaniasis is considered a priority by the World Health Organization. Parenteral administration of pentavalent antimonials for the treatment of all forms of leishmaniasis, including cutaneous leishmaniasis, has several limitations. The therapy is long, requires repeated doses, and adverse reactions are frequent. Topical treatment is an attractive alternative for cutaneous leishmaniasis, offering significant advantages over systemic therapy: fewer adverse effects, ease of administration, and lower costs. The present inventors aimed to provide a fixed-dose topical composition containing at least one antileishmanial compound, providing adequate absorption of the active ingredient. Another objective of the present invention is to provide a topical, fixed-dose formulation containing a combination of antileishmanial compounds that has sufficient efficacy and safety to be used in the treatment of cutaneous leishmaniasis.
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公开(公告)号：US20190187157A1
公开(公告)日：2019-06-20
申请号：US16281648
申请日：2019-02-21
发明人： Roney Santos COIMBRA , Rosiane A da Silva PEREIRA , Guilherme Correa DE OLIVEIRA , Ana Paula CORDEIRO
IPC分类号： G01N33/68 , G01N33/569 , G01N33/53 , G01N33/92
CPC分类号： G01N33/6896 , G01N33/5308 , G01N33/56911 , G01N33/6893 , G01N33/92 , G01N2333/4716 , G01N2333/4737 , G01N2333/745 , G01N2333/775 , G01N2800/28 , G01N2800/50
摘要： The instant invention relates to a qualitative predictive method, to a method, use and kit applied to the early differential diagnosis of the most prevalent forms of bacterial and viral meningitis, enabling to detect and distinguish the different forms of meningitis. The invention uses a qualitative predictive method based on combined detection and sequential analysis of the presence/absence of at least three out of four specific biomarkers.
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5.发明申请PROTEINS WITH REPETITIVE BACTERIAL-IG-LIKE (BIG) DOMAINS PRESENT IN LEPTOSPIRA SPECIES 有权具有重复性细菌类型（大）的蛋白质在LEPTOSPIRA物种中存在公开(公告)号：US20170037114A1
公开(公告)日：2017-02-09
申请号：US15334128
申请日：2016-10-25
申请人： U.S. Government represented by the Department of Veterans Affairs , The Regents of the University of California , Cornell Research Foundation, Inc. , Fundação Oswaldo Cruz - FIOCRUZ
发明人： Albert I. Ko , Mitermayer Galvão Reis , Julio Henrique Rosa Croda , Isadora Cristina Siqueira , David A. Haake , James Matsunaga , Lee W. Riley , Michele Barocchi , Tracy Ann Young
IPC分类号： C07K16/12 , G01N33/569 , C12Q1/68
CPC分类号： C07K16/1207 , A61K2039/505 , C07H21/04 , C07K14/20 , C12Q1/68 , C12Q1/689 , G01N33/56911 , G01N2469/20 , Y02A50/56
摘要： The invention relates to three isolated DNA molecules that encode for proteins, BigL1, BigL2 and BigL3, in the Leptospira sp bacterium which have repetitive Bacterial-Ig-like (Big) domains and their use in diagnostic, therapeutic and vaccine applications. According to the present invention, the isolated molecules encoding for BigL1, BigL2 and BigL3 proteins are used for the diagnosis and prevention of infection with Leptospira species that are capable of producing disease in humans and other mammals, including those of veterinary importance.
摘要翻译： 本发明涉及编码具有重复的细菌Ig样（Big）结构域的钩端螺菌属细菌中的蛋白质BigL1，BigL2和BigL3的三种分离的DNA分子，以及它们在诊断，治疗和疫苗应用中的应用。 根据本发明，编码BigL1，BigL2和BigL3蛋白的分离的分子用于诊断和预防能够在人和其他哺乳动物（包括具有兽医重要性的哺乳动物）中产生疾病的钩端螺旋体属物种的感染。
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6.发明申请QUALITATIVE PREDICTIVE METHOD FOR DIFFERENTIAL DIAGNOSIS OF PNEUMOCOCCAL, MENINGOCOCCAL AND VIRAL MENINGITIS, METHOD AND KIT FOR DIFFERENTIAL DIAGNOSIS OF MENINGITIS 审中-公开用于差异性诊断肺炎，男性和女性男性的定性预测方法，方法和手段对男性的差异性诊断公开(公告)号：US20170016920A1
公开(公告)日：2017-01-19
申请号：US15121869
申请日：2015-02-24
发明人： Roney Santos COIMBRA , Rosiane A da Silva PEREIRA , Guilherme Correa DE OLIVEIRA , Ana Paula CORDEIRO
CPC分类号： G01N33/6896 , G01N33/5308 , G01N33/56911 , G01N33/6893 , G01N33/92 , G01N2333/4716 , G01N2333/4737 , G01N2333/745 , G01N2333/775 , G01N2800/28 , G01N2800/50
摘要： The instant invention relates to a qualitative predictive method, to a method, use and kit applied to the early differential diagnosis of the most prevalent forms of bacterial and viral meningitis, enabling to detect and distinguish the different forms of meningitis. The invention uses a qualitative predictive method based on combined detection and sequential analysis of the presence/absence of at least three out of four specific biomarkers.
摘要翻译： 本发明涉及定性预测方法，应用于应用于最常见的细菌和病毒性脑膜炎形式的早期鉴别诊断的方法，用途和试剂盒，能够检测和区分不同形式的脑膜炎。 本发明使用基于组合检测和顺序分析四种特定生物标志物中至少三种的存在/不存在的定性预测方法。
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7.发明授权Proteins with repetitive bacterial-Ig-like (Big) domains present in leptospira species 有权在钩端螺旋体中存在重复的细菌Ig样（大）结构域的蛋白质公开(公告)号：US08802835B2
公开(公告)日：2014-08-12
申请号：US13869660
申请日：2013-04-24
申请人： The United States of Americas as represented by the Department of Veterans Affairs , The Regents of the University of California , Cornell Research Foundation, Inc. , Fundação Oswaldo Cruz—FIOCRUZ
发明人： Albert I. Ko , Mitermayer Galvão Reis , Julio Henrique Rosa Croda , Isadora Cristina Siqueira , David A. Haake , James Matsunaga , Lee W. Riley , Michele Barocchi , Tracy Ann Young
IPC分类号： C07H21/02
CPC分类号： C07K16/1207 , A61K2039/505 , C07H21/04 , C07K14/20 , C12Q1/68 , C12Q1/689 , G01N33/56911 , G01N2469/20 , Y02A50/56
摘要： The invention relates to three isolated DNA molecules that encode for proteins, BigL1, BigL2 and BigL3, in the Leptospira sp bacterium which have repetitive Bacterial-Ig-like (Big) domains and their use in diagnostic, therapeutic and vaccine applications. According to the present invention, the isolated molecules encoding for BigL1, BigL2 and BigL3 proteins are used for the diagnosis and prevention of infection with Leptospira species that are capable of producing disease in humans and other mammals, including those of veterinary importance.
摘要翻译： 本发明涉及编码具有重复的细菌Ig样（Big）结构域的钩端螺菌属细菌中的蛋白质BigL1，BigL2和BigL3的三种分离的DNA分子，以及它们在诊断，治疗和疫苗应用中的应用。 根据本发明，编码BigL1，BigL2和BigL3蛋白的分离的分子用于诊断和预防能够在人和其他哺乳动物（包括具有兽医重要性的哺乳动物）中产生疾病的钩端螺旋体属物种的感染。
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公开(公告)号：US11129561B2
公开(公告)日：2021-09-28
申请号：US16085775
申请日：2017-03-17
发明人： Dimitri Marques Abramov , Paulo Ricardo Galhanone , Marcos Antonio Dias Lima , Carlos Henrique Quintanilha Martins
IPC分类号： A61B5/0484 , A61B5/05 , A61B5/16 , A61B5/377 , G16Z99/00 , A61B5/00 , A61B5/38 , A61B5/378 , A61B5/0531 , A61B5/11 , G16H20/70
摘要： This invention relates to a device that is intended to synchronize electroencephalograms (EEGs), recorded by any digital equipment, to physical events (sensorial, visual or auditory stimuli) and behavioral events (motor response, vocal response), in order to allow EEG signal mediation for the purpose of visualizing Evoked Potentials or Event-Related Potentials, which are important research subjects in the neurosciences and clinical investigations into neurological and psychiatric pathologies. This invention allows any digital EEG device to be transformed into equipment that can record Evoked Potentials. This invention also provides a method for analog synchronization of EEGs with oscillating electric light-related events and motor behaviors.
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公开(公告)号：US20210121544A1
公开(公告)日：2021-04-29
申请号：US16963173
申请日：2019-01-18
摘要： The present invention refers to polypeptides with asparaginase activity that have an increased rate of self-processing compared to human wild L-asparaginase (ASRGL1), with mutation in the ASRGL1 glycine rich loop called HGG loop (Histidine 8-Glycine 9-Glycine 10). Polynucleotides that encode the polypeptides of invention are also described here, expression cassettes comprising so-called polynucleotides, expression vectors, host cells, pharmaceutical compositions, uses of the invention polypeptide in the manufacture of a preventive medicine or cancer treatment and methods to produce the polypeptide of invention and to prevent or treat cancer.
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公开(公告)号：US10254296B2
公开(公告)日：2019-04-09
申请号：US15121869
申请日：2015-02-24
发明人： Roney Santos Coimbra , Rosiane A da Silva Pereira , Guilherme Correa De Oliveira , Ana Paula Cordeiro
IPC分类号： A61K49/00 , A61B5/055 , A61K39/095 , G01N33/68 , G01N33/569 , G01N33/53 , G01N33/92
摘要： The instant invention relates to a qualitative predictive method, to a method, use and kit applied to the early differential diagnosis of the most prevalent forms of bacterial and viral meningitis, enabling to detect and distinguish the different forms of meningitis. The invention uses a qualitative predictive method based on combined detection and sequential analysis of the presence/absence of at least three out of four specific biomarkers.
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