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    DIAGNOSTIC KIT FOR THE DETECTION OF EARLY ACUTE LEPTOSPIROSIS
    2.
    发明申请
    DIAGNOSTIC KIT FOR THE DETECTION OF EARLY ACUTE LEPTOSPIROSIS 审中-公开
    用于检测早期急性前列腺增生症的诊断试剂盒

    公开(公告)号：US20150004623A1

    公开(公告)日：2015-01-01

    申请号：US14349970

    申请日：2012-07-02

    申请人： Abdul Rani Bahaman ,  Arivudainambi Seenichamy

    发明人： Abdul Rani Bahaman ,  Arivudainambi Seenichamy

    IPC分类号： G01N33/569 ,  C07K16/12

    CPC分类号： G01N33/56911 ,  C07K16/1207 ,  C07K2317/20 ,  G01N2333/20 ,  Y02A50/56

    摘要： The present invention relates to a diagnostic method for the detection of acute leptospirosis. The method of the invention allows for a quick, specific and sensitive detection of the disease caused by pathogenic Leptospira. The described method is based on the immunological detection of the protein LipL21, a membrane protein expressed specifically by pathogenic strains of Leptospira. Furthermore, the present invention relates to the development of a diagnostic device that allows positive diagnosis to be conducted in the early and critical stage of the infection. The preferred diagnostic device of the invention is a lateral flow test, which as a hand-held assay, is easy to use and facilitates diagnosis of leptospirosis in the first 5 days of infection. Further disclosed is the antibody raised against the LipL21 protein as well as its respective uses in the diagnostic methods and devices. Finally, a diagnostic kit is disclosed containing the inventive materials described herein to conduct diagnosis of acute leptospirosis during the critical early stage of infection. The first 5 days of the infection is where the subject or patient could succumb to the disease. Diagnosis of the disease at this critical stage of infection would then advise the affected patient to have immediate systemic antibiotic treatment and thereby, avoid succumbing to the disease.

    摘要翻译： 本发明涉及一种检测急性钩端螺旋体病的诊断方法。 本发明的方法能够快速，具体和灵敏地检测由致病性钩端螺旋体引起的疾病。 所描述的方法基于蛋白质LipL21的免疫学检测，LipL21是由钩端螺旋体病原菌株特异性表达的膜蛋白。 此外，本发明涉及诊断装置的开发，其允许在感染的早期和关键阶段进行阳性诊断。 本发明的优选诊断装置是侧流测试，其作为手持测定法易于使用，并且有助于在感染的前5天内诊断钩端螺旋体病。 还公开了针对LipL21蛋白产生的抗体及其在诊断方法和装置中的各自用途。 最后，公开了一种诊断试剂盒，其包含本文所述的本发明材料以在感染的关键早期阶段进行急性钩端螺旋体病的诊断。 感染的前5天是受试者或患者可能屈服于该疾病的地方。 然后在感染的这个关键阶段诊断疾病​​，然后建议受影响的患者立即进行全身抗生素治疗，从而避免屈服于该疾病。

    COMPOSITIONS COMPRISING CHIMERIC OSPA MOLECULES AND METHODS OF USE THEREOF
    4.
    发明申请
    COMPOSITIONS COMPRISING CHIMERIC OSPA MOLECULES AND METHODS OF USE THEREOF 有权
    包含重组OSPA分子的组合物及其使用方法

    公开(公告)号：US20140030284A1

    公开(公告)日：2014-01-30

    申请号：US13939759

    申请日：2013-07-11

    申请人： BAXTER HEALTHCARE SA ,  BAXTER INTERNATIONAL INC.

    发明人： P. Noel Barrett ,  Gerald Aichinger ,  Brian A. Crowe ,  Ian Livey ,  Nina Wressnigg

    IPC分类号： A61K38/16

    CPC分类号： A61K38/164 ,  A61K39/0225 ,  A61K2039/55505 ,  A61K2039/58 ,  A61K2039/70 ,  C07K16/1207 ,  C07K2317/33 ,  Y02A50/40 ,  Y02A50/401

    摘要： The invention relates to the development of chimeric OspA molecules for use in a new Lyme vaccine. More specifically, the chimeric OspA molecules comprise the proximal portion from one OspA serotype, together with the distal portion from another OspA serotype, while retaining antigenic properties of both of the parent polypeptides. The chimeric OspA molecules are delivered alone or in combination to provide protection against a variety of Borrelia genospecies. The invention also provides methods for administering the chimeric OspA molecules to a subject in the prevention and treatment of Lyme disease or borreliosis.

    摘要翻译： 本发明涉及用于新的莱姆疫苗的嵌合型OspA分子的开发。 更具体地，嵌合OspA分子包含来自一个OspA血清型的近端部分以及来自另一种OspA血清型的远侧部分，同时保留两种亲本多肽的抗原性质。 嵌合的OspA分子单独或组合递送以提供针对各种疏螺旋体基因属的保护。 本发明还提供了在预防和治疗莱姆病或硼状血症中向受试者施用嵌合OspA分子的方法。