公开(公告)号：US20060094671A1

公开(公告)日：2006-05-04

申请号：US11300464

申请日：2005-12-15

Applicant: Gary Jacob ,  Timothy Block ,  Raymond Dwek

Inventor： Gary Jacob ,  Timothy Block ,  Raymond Dwek

IPC: A61K31/7076 ,  A61K31/7072 ,  A61K31/7056 ,  A61K31/445

CPC classification number: C07D211/46 ,  A61K31/445 ,  A61K45/06

Abstract: Provided are methods and compositions for treating hepatitis virus infections in mammals, especially humans. The methods comprise (1) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds in combination with nucleoside antiviral agents, nucleotide antiviral agents, mixtures thereof, or immunomodulating/immunostimulating agents, or (2) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds in combination with nucleoside antiviral agents, nucleotide antiviral agents, or mixtures thereof, and immunomodulating/immunostimulating agents.

公开(公告)号：US20070015780A1

公开(公告)日：2007-01-18

申请号：US10548794

申请日：2004-03-10

Applicant: Donald Picker ,  Geoffrey Henson ,  Simon Fricker ,  Kunwar Shailubhai ,  Gary Jacob

Inventor： Donald Picker ,  Geoffrey Henson ,  Simon Fricker ,  Kunwar Shailubhai ,  Gary Jacob

IPC: A61K31/4747 ,  A61K31/403

CPC classification number: A61K31/403 ,  A61K31/438 ,  A61K31/454 ,  A61K31/4747 ,  A61K45/06 ,  A61K2300/00

Abstract: A method of treating cancer by administering a therapeutically effective amount of a compound represented by the following Formula (I), or salt, hydrate, or solvate thereof; wherein: n represents a number from 3 to 7; m represents a number from 1 to 2; R1 and R2 independently represent a hydrogen atom or are a substituted or unsubstituted, branched or unbranched or cyclic, alkyl provided that the total number of carbon atoms represented by R1 and R2 when taken together is no less than 5 and no greater than 10; or R1 and R2 together independently represent a cyclic alkyl group having no less than 3 or no more than 7 carbon atoms; R3 and R4 independently represent a hydrogen atom or a saturated or unsaturated, substituted or unsubstituted, branched or unbranched or cyclic, hydrocarbyl radical.

Abstract translation: 通过施用治疗有效量的由下式（I）表示的化合物或其盐，水合物或溶剂合物来治疗癌症的方法; 其中：n表示3〜7的数; m表示1〜2的数; R 1和R 2独立地表示氢原子，或者是取代或未取代的，支链或非支链或环状烷基，条件是由R 1表示的碳原子总数， 当共在一起时，SUB> 1和R 2 2不小于5且不大于10; 或R 1和R 2共同独立地表示具有不少于3个或不超过7个碳原子的环状烷基; R 3和R 4独立地表示氢原子或饱和或不饱和的取代或未取代的支链或非支链或环状烃基。

公开(公告)号：US20060106065A1

公开(公告)日：2006-05-18

申请号：US11300463

申请日：2005-12-15

Applicant: Gary Jacob ,  Timothy Block ,  Raymond Dwek

Inventor： Gary Jacob ,  Timothy Block ,  Raymond Dwek

IPC: A61K31/445

CPC classification number: C07D211/46 ,  A61K31/445 ,  A61K45/06

Abstract: Provided are methods and compositions for treating hepatitis virus infections in mammals, especially humans. The methods comprise (1) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds in combination with nucleoside antiviral agents, nucleotide antiviral agents, mixtures thereof, or immunomodulating/immunostimulating agents, or (2) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds in combination with nucleoside antiviral agents, nucleotide antiviral agents, or mixtures thereof, and immunomodulating/immunostimulating agents.

Abstract translation: 提供用于治疗哺乳动物，特别是人类的肝炎病毒感染的方法和组合物。 方法包括（1）与核苷抗病毒剂，核苷酸抗病毒剂，其混合物或免疫调节/免疫刺激剂组合施用N-取代的-1,5-二脱氧-1,5-亚氨基-D-葡萄糖醇化合物，或（2 ）与核苷抗病毒剂，核苷酸抗病毒剂或其混合物以及免疫调节/免疫刺激剂组合施用N-取代的-1,5-二脱氧-1,5-亚氨基-D-葡萄糖醇化合物。

公开(公告)号：US20050250801A1

公开(公告)日：2005-11-10

申请号：US10796292

申请日：2004-03-10

Applicant: Kunwar Shailubhai ,  Gary Jacob ,  Donald Picker ,  Geoffrey Henson ,  Simon Fricker

Inventor： Kunwar Shailubhai ,  Gary Jacob ,  Donald Picker ,  Geoffrey Henson ,  Simon Fricker

IPC: A61K20060101 ,  A61K31/403 ,  A61K31/438 ,  A61K31/454 ,  A61K31/4747 ,  A61K38/00 ,  A61K45/06

CPC classification number: A61K31/403 ,  A61K31/438 ,  A61K31/454 ,  A61K31/4747 ,  A61K45/06 ,  A61K2300/00

Abstract: A method of treating cancer by administering a therapeutically effective amount of a compound represented by the following Formula (I), or salt, hydrate, or solvate thereof: wherein: n represents a number from 3 to 7; m represents a number from 1 to 2; R1 and R2 independently represent a hydrogen atom or are a substituted or unsubstituted, branched or unbranched or cyclic, alkyl provided that the total number of carbon atoms represented by R1 and R2 when taken together is no less than 5 and no greater than 10; or R1 and R2 together independently represent a cyclic alkyl group having no less than 3 or no more than 7 carbon atoms; R3 and R4 independently represent a hydrogen atom or a saturated or unsaturated, substituted or unsubstituted, branched or unbranched or cyclic, hydrocarbyl radical.

Abstract translation: 通过给予治疗有效量的由下式（I）表示的化合物或其盐，水合物或溶剂合物来治疗癌症的方法：其中：n表示3至7的数; m表示1〜2的数; R 1和R 2独立地表示氢原子，或者是取代或未取代的，支链或非支链或环状烷基，条件是由R 1表示的碳原子总数， 当共在一起时，SUB> 1和R 2 2不小于5且不大于10; 或R 1和R 2共同独立地表示具有不少于3个或不超过7个碳原子的环状烷基; R 3和R 4独立地表示氢原子或饱和或不饱和的取代或未取代的支链或非支链或环状烃基。

公开(公告)号：US20050267153A1

公开(公告)日：2005-12-01

申请号：US10910197

申请日：2004-08-03

Applicant: Richard Mueller ,  Martin Bryant ,  Richard Partis ,  Gary Jacob ,  Timothy Block ,  Raymond Dwek

Inventor： Richard Mueller ,  Martin Bryant ,  Richard Partis ,  Gary Jacob ,  Timothy Block ,  Raymond Dwek

IPC: A61K31/445 ,  A61K31/7042 ,  A61K31/7052 ,  A61K31/7064 ,  A61K31/7068 ,  A61K45/06 ,  A61P1/16 ,  A61P31/20 ,  C07D211/46 ,  C07H19/10

CPC classification number: C07D211/46 ,  A61K31/445 ,  A61K45/06

Abstract: Provided are methods and compositions for treating hepatitis virus infections in mammals, especially humans. The methods comprise (1) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds alone or in combination with nucleoside antiviral agents, nucleotide antiviral agents, mixtures thereof, or immunomodulating/immunostimulating agents, or (2) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds alone or in combination with nucleoside antiviral agents, nucleotide antiviral agents, or mixtures thereof, and immunomodulating/immuno-stimulating agents.

Abstract translation: 提供用于治疗哺乳动物，特别是人类的肝炎病毒感染的方法和组合物。 方法包括（1）单独或与核苷抗病毒剂，核苷酸抗病毒剂，其混合物或免疫调节/免疫刺激剂单独或组合施用N-取代的-1,5-二脱氧-1,5-亚氨基-D-葡萄糖醇化合物，或 （2）单独或与核苷抗病毒剂，核苷酸抗病毒剂或其混合物以及免疫调节/免疫刺激剂组合施用N-取代-1,5-二脱氧-1,5-亚氨基-D-葡萄糖醇化合物。

公开(公告)号：US5776083A

公开(公告)日：1998-07-07

申请号：US343350

申请日：1994-11-22

Applicant: Gary Jacob ,  Charles J. Aplin, III

Inventor： Gary Jacob ,  Charles J. Aplin, III

IPC: A63B23/00 ,  A61H1/00

CPC classification number: A63B23/00 ,  A63B2023/003 ,  A63B2023/006 ,  Y10S482/907

Abstract: The present invention provides an exercise bar for use in rehabilitative therapy of joint structures, especially those of an impaired limb of a user. The exercise bar preferably comprises an elongated shaft having a longitudinal axis and two ends, a loop member comprising a loop attached to a first end of the shaft, and a handle member attached to a second end of the shaft at an angle to both the longitudinal axis of the shaft and the plane defined by the loop of the loop member. The loop preferably is in the shape of an isosceles triangle with the angles forming arcuated notches for receiving a portion of the user's impaired limb. Once the user's limb is seated within one of the notches, the shaft may be rotated about it axis to enable rotational, resistive stretching of a first joint complex or may be reciprocated along its axis to enable the performance of various exercises.

Abstract translation: 本发明提供一种用于关节结构的康复治疗的运动杆，特别是使用者的受损肢体的康复治疗。 运动杆优选地包括具有纵向轴线和两个端部的细长轴，环形构件，包括附接到轴的第一端的环，以及手柄构件，其以与纵向轴线成两个角度的角度附接到轴的第二端 轴和由环构件的环限定的平面。 该环优选为等腰三角形的形状，其中角度形成弧形切口，用于接收使用者受损肢体的一部分。 一旦使用者的肢体位于其中一个切口内，则轴可围绕其轴线旋转，以使得第一关节复合体能够旋转，阻力拉伸，或者可以沿着其轴线往复运动以使得能够进行各种锻炼。

公开(公告)号：US20060154868A1

公开(公告)日：2006-07-13

申请号：US11347115

申请日：2006-02-02

Applicant: Kunwar Shailubhai ,  Gregory Nikiforovich ,  Gary Jacob

Inventor： Kunwar Shailubhai ,  Gregory Nikiforovich ,  Gary Jacob

IPC: A61K38/17 ,  A61K38/10 ,  C07K14/705 ,  C07K7/08

CPC classification number: C07K7/64 ,  A61K38/00 ,  A61K38/10 ,  A61K38/12 ,  A61K45/06 ,  A61K47/60 ,  C07K7/08 ,  C07K7/50 ,  C07K2299/00 ,  Y02A50/473

Abstract: A method of treatment of inflamed, pre-cancerous or cancerous tissue or polyps in a mammalian subject is disclosed. The treatment involves administration of a composition of at least one peptide agonist of a guanylate cyclase receptor and/or other small molecules that enhance intracellular production of cGMP. The at least one peptide agonist of a guanylate cyclase receptor may be administered either alone or in combination with an inhibitor of cGMP-dependent phosphodiesterase. The inhibitor may be a small molecule, peptide, protein or other compound that inhibits the degradation of cGMP. Without requiring a particular mechanism of action, this treatment may restore a healthy balance between proliferation and apoptosis in the subject's population of epithelial cells, and also suppress carcinogenesis. Thus, the method may be used to treat, inter alia, inflammation, including gastrointestinal inflammatory disorders, general organ inflammation and asthma, and carcinogenesis of the lung, gastrointestinal tract, bladder, testis, prostate and pancreas, or polyps.

公开(公告)号：US07043063B1

公开(公告)日：2006-05-09

申请号：US10069291

申请日：2000-07-19

Applicant: Julia Alison Noble ,  Gary Jacob

Inventor： Julia Alison Noble ,  Gary Jacob

IPC: G06K9/00

CPC classification number: G06T7/0016 ,  A61B6/508 ,  G06T7/246 ,  G06T7/251 ,  G06T2207/10132 ,  G06T2207/30048

Abstract: A method of analysing a sequence of images of a deformable object in non-rigid motion involves modeling the boundary using a non-rigid contour. A representation of movement of the contour through the sequence of images is calculated using a tracking space shape. The calculated movement representation is decomposed using an interpretational space shape that is different than the tracking space shape.

Abstract translation: 在非刚性运动中分析可变形物体的图像序列的方法涉及使用非刚性轮廓对边界进行建模。 使用跟踪空间形状计算通过图像序列的轮廓的移动的表示。 使用与跟踪空间形状不同的解释空间形状来分解计算的运动表示。

公开(公告)号：USD376507S

公开(公告)日：1996-12-17

申请号：US32813

申请日：1994-12-29

Applicant: Gary Jacob

Designer： Gary Jacob

公开(公告)号：US5577620A

公开(公告)日：1996-11-26

申请号：US365694

申请日：1994-12-29

Applicant: Gary Jacob

Inventor： Gary Jacob

IPC: A47B81/06 ,  G11B23/023 ,  G11B33/04 ,  A47F7/00

CPC classification number: A47B81/068 ,  G11B23/0236 ,  G11B33/0483

Abstract: A storage rack for storing compact disc, cassette and videotape cases in a vertical stack. The storage rack consists of a base having a tower support with a top surface set at a predetermined oblique angle. Modular components are stacked on top of the base to form a storage tower. The modular components and the corresponding storage slots are also oriented at the predetermined oblique angle. The stored cases disposed in the slots display their title at an upwardly turned angle which makes them easy to view. The base may be equipped with several tower supports to support several storage towers facing in similar or different directions.

Abstract translation: 用于在垂直堆叠中存储光盘，盒和录像带的存储架。 存储架由具有顶部表面设置为预定倾斜角度的塔架支撑的基座构成。 模块化部件堆叠在基座的顶部以形成储存塔。 模块化部件和对应的存储槽也以预定的倾斜角定向。 设置在槽中的存储的盒子以向上的转角显示它们的标题，这使得它们容易观看。 基座可以配备有几个塔架支撑件以支撑面向相似或不同方向的几个储存塔。