公开(公告)号：US20100247443A1

公开(公告)日：2010-09-30

申请号：US12739173

申请日：2008-10-29

申请人： Haruhi Iwaki ,  Mariko Egawa

发明人： Haruhi Iwaki ,  Mariko Egawa

IPC分类号： A61K49/00 ,  A61P17/16 ,  G06F19/00 ,  G01J3/44

CPC分类号： G01N33/5082 ,  A61B5/0075 ,  A61B5/445 ,  G01N21/65 ,  G01N33/5088

摘要： An effectiveness evaluating method evaluates effectiveness of an external preparation for skin for protection against ultraviolet irradiation after the external preparation is applied to the skin. The method includes a measurement step of measuring an amount of urocanic acid in a horny cell layer by Raman spectroscopy both before and after the application of the external preparation and both before and after exposure to ultraviolet irradiation, an index derivation step of computing at least one index for evaluating the effectiveness of the external preparation based on results of the measurement obtained in the measurement step, and an evaluation step of evaluating the effectiveness of the external preparation by using the index obtained in the index derivation step.

摘要翻译： 有效性评估方法评估外用制剂施用于皮肤后的皮肤外用制剂的有效性以防紫外线照射。 该方法包括测量步骤，其在暴露于紫外线照射之前和之后，通过拉曼光谱法测量在外用制剂施用之前和之后以及在紫外线照射之前和之后测量角质细胞层中的尿布氨酸的量，计算至少一种 用于基于在测量步骤中获得的测量结果来评估外部制剂的有效性的指标，以及评估步骤，通过使用在指标推导步骤中获得的指数来评估外部制剂的有效性。

公开(公告)号：US20080064723A1

公开(公告)日：2008-03-13

申请号：US11665214

申请日：2005-10-13

申请人： Ritsuro Ideta ,  Yosuke Nakazawa ,  Haruhi Iwaki ,  Akihiro Ishino ,  Masahiro Tajima

发明人： Ritsuro Ideta ,  Yosuke Nakazawa ,  Haruhi Iwaki ,  Akihiro Ishino ,  Masahiro Tajima

IPC分类号： A61K31/13 ,  A61K31/195 ,  A61K31/445 ,  A61P17/00

CPC分类号： A61K8/4926 ,  A61K8/44 ,  A61K31/133 ,  A61K31/196 ,  A61K31/215 ,  A61K31/445 ,  A61K31/4465 ,  A61Q5/10

摘要： An anti-hair graying agent containing, as an active ingredient, a substance having a superior anti-hair graying action, for example, aminocyclohexane carboxylic acid, aminocyclohexane carboxylic acid esters such as aminocyclohexane carboxylic acid ethyl ester, aminocyclohexane derivatives such as aminocyclohexanol, and piperidinecarboxylic acid, piperidinecarboxylic acid esters such as piperidinecarboxylic acid ethyl ester, and piperidine derivatives such as hydroxypiperidine is provided.

摘要翻译： 作为活性成分，含有优异的防毛发作用的物质，例如氨基环己烷羧酸，氨基环己烷羧酸酯如氨基环己烷羧酸乙酯，氨基环己烷衍生物如氨基环己醇的抗头发变灰剂和 哌啶羧酸，哌啶羧酸酯如哌啶羧酸乙酯和哌啶衍生物如羟基哌啶。

公开(公告)号：US20110091387A1

公开(公告)日：2011-04-21

申请号：US12742804

申请日：2008-11-17

申请人： Sam W. Lee ,  Lakshmi Raj ,  Anna I. Mandinova ,  Haruhi Iwaki ,  Yuji Katsuta ,  Jotaro Nakanishi

发明人： Sam W. Lee ,  Lakshmi Raj ,  Anna I. Mandinova ,  Haruhi Iwaki ,  Yuji Katsuta ,  Jotaro Nakanishi

IPC分类号： A61K49/00 ,  A61K31/352 ,  A61K8/18 ,  A61K31/34 ,  A61K31/4184 ,  A61K31/12 ,  A61K31/435 ,  A61K31/44 ,  A61K31/427 ,  A61K31/135 ,  A61K31/17 ,  A61K31/165 ,  A61K31/7048 ,  A61K31/41 ,  A61K31/203 ,  G01N33/53 ,  C12Q1/68 ,  A61P17/00 ,  A61P17/16

CPC分类号： A61K31/353 ,  A61K8/498 ,  A61Q19/007 ,  A61Q19/08

摘要： The RhoE GTPase pathway has been identified as a target for screening and treatment methods for the prevention and/or reduction of short- and long-term UVB-induced skin damage, e.g., the prevention and/or reduction of UVB-induced wrinkles. The invention thus features screening and treatment methods for prevention or reduction of UVB-induced sin damage, and related compositions, e.g., cosmetic compositions.

摘要翻译： 已经将RhoE GTPase途径鉴定为用于预防和/或减少短期和长期UVB诱导的皮肤损伤的筛选和治疗方法的目标，例如预防和/或减少UVB诱导的皱纹。 因此，本发明具有用于预防或减少UVB诱导的sin损伤的筛选和治疗方法以及相关组合物，例如化妆品组合物。

公开(公告)号：US20110065794A1

公开(公告)日：2011-03-17

申请号：US12926351

申请日：2010-11-12

申请人： Makoto Tsunenaga ,  Haruhi Iwaki ,  Toshii Iida ,  Mikiko Kaminuma ,  Masaru Suetsugu ,  Keiko Takada ,  Shinji Inomata

发明人： Makoto Tsunenaga ,  Haruhi Iwaki ,  Toshii Iida ,  Mikiko Kaminuma ,  Masaru Suetsugu ,  Keiko Takada ,  Shinji Inomata

IPC分类号： A61K31/197 ,  A61Q19/08

CPC分类号： A61K8/44 ,  A61K8/445 ,  A61Q19/08

摘要： A wrinkle-preventing and -improving composition comprising one or more than one compound selected from the group consisting of α-amino acid derivatives represented by the following general formula (1) and salts thereof: wherein, R1 represents hydrogen atom, CH3 group or CH2OH group, R2 and R3 each independently represent hydrogen atom, alkyl group having 1 to 4 carbons, provided that R2 and R3 cannot be hydrogen atom at the same time, or R2 and R3 together with N atom to which they are bound may form a ring structure having a total carbon number of 4 to 6, in which case said ring structure may optionally contain an oxygen atom as a heteroatom, R4 represents hydrogen atom, alkyl group having 1 to 18 carbons, wherein when R1 and R4 are hydrogen atom, it cannot be that one of R2 and R3 is benzyloxycarbonyl group and the other is hydrogen atom.

摘要翻译： 一种防皱和改善组合物，其包含一种或多于一种选自下列通式（1）表示的α-氨基酸衍生物及其盐的化合物：其中，R 1表示氢原子，CH 3基或CH 2 OH 基团，R 2和R 3各自独立地表示氢原子，具有1至4个碳的烷基，条件是R 2和R 3不能同时为氢原子，或者R 2和R 3与它们所连接的N原子可以形成环 总碳数为4〜6的结构，在这种情况下，所述环结构可任选地含有氧原子作为杂原子，R4表示氢原子，具有1至18个碳原子的烷基，其中当R 1和R 4为氢原子时， 不能是R2和R3之一是苄氧基羰基，另一个是氢原子。

公开(公告)号：US20100168468A1

公开(公告)日：2010-07-01

申请号：US11996851

申请日：2006-07-26

申请人： Makoto TSUNENAGA ,  Haruhi IWAKI ,  Toshii IDIDA ,  Mikiko KAMINUMA ,  Masaru SUETSUGU ,  Keiko TAKADA ,  Shinji INOMATA

发明人： Makoto TSUNENAGA ,  Haruhi IWAKI ,  Toshii IDIDA ,  Mikiko KAMINUMA ,  Masaru SUETSUGU ,  Keiko TAKADA ,  Shinji INOMATA

IPC分类号： C07C229/34 ,  C07C229/12

CPC分类号： A61K8/44 ,  A61K8/445 ,  A61Q19/08

摘要： A wrinkle-preventing and -improving composition comprising one or more than one compound selected from the group consisting of α-amino acid derivatives represented by the following general formula (1) and salts thereof: wherein, R1 represents hydrogen atom, CH3 group or CH2OH group, R2 and R3 each independently represent hydrogen atom, alkyl group having 1 to 4 carbons, provided that R2 and R3 cannot be hydrogen atom at the same time, or R2 and R3 together with N atom to which they are bound may form a ring structure having a total carbon number of 4 to 6, in which case said ring structure may optionally contain an oxygen atom as a heteroatom, R4 represents hydrogen atom, alkyl group having 1 to 18 carbons, wherein when R1 and R4 are hydrogen atom, it cannot be that one of R2 and R3 is benzyloxycarbonyl group and the other is hydrogen atom.

摘要翻译： 一种防皱和改善组合物，其包含一种或多于一种选自下列通式（1）表示的α-氨基酸衍生物及其盐的化合物：其中，R 1表示氢原子，CH 3基或CH 2 OH 基团，R 2和R 3各自独立地表示氢原子，具有1至4个碳的烷基，条件是R 2和R 3不能同时为氢原子，或者R 2和R 3与它们所连接的N原子可以形成环 总碳数为4〜6的结构，在这种情况下，所述环结构可任选地含有氧原子作为杂原子，R4表示氢原子，具有1至18个碳原子的烷基，其中当R 1和R 4为氢原子时， 不能是R2和R3之一是苄氧基羰基，另一个是氢原子。