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31 条记录 (耗时 0.022 秒)

    PARAKERATOSIS INHIBITOR AND SKIN PREPARATION FOR EXTERNAL USE
    2.
    发明申请
    PARAKERATOSIS INHIBITOR AND SKIN PREPARATION FOR EXTERNAL USE 审中-公开
    PARAKERATOSIS抑制剂和皮肤外用品的制备

    公开(公告)号：US20120253064A1

    公开(公告)日：2012-10-04

    申请号：US13467254

    申请日：2012-05-09

    申请人： Mikiko Kaminuma ,  Masaru Suetsugu ,  Toshii Iida ,  Shinji Inomata ,  Keiko Takada ,  Yuji Katsuta

    发明人： Mikiko Kaminuma ,  Masaru Suetsugu ,  Toshii Iida ,  Shinji Inomata ,  Keiko Takada ,  Yuji Katsuta

    IPC分类号： C07C309/26

    CPC分类号： A61K8/0212 ,  A61K8/44 ,  A61K8/466 ,  A61Q1/02 ,  A61Q19/00

    摘要： To provide a parakeratosis inhibitor, pore reducing agent and skin roughness preventing/ameliorating agent that exhibit capabilities of parakeratosis inhibition, pore reduction, skin roughness prevention/amelioration, etc., and further provide a skin preparation for external use having these capabilities. There are provided a parakeratosis inhibitor, a pore reducing agent and a skin roughness preventing/ameliorating agent each comprising at least one compound selected from the group consisting of specified glycine derivatives and salts thereof and specified aminosulfuric acid derivatives and salts thereof. Still further, there are provided skin preparations for external use comprising these compounds.

    摘要翻译： 提供表现角化不全抑制，减孔，皮肤粗糙度防止/改善等的角化不全抑制剂，减孔剂和皮肤粗糙度防止/改善剂，进一步提供具有这些能力的外用皮肤制剂。 提供了一种角化不全抑制剂，减孔剂和皮肤粗糙度防止/改善剂，其各自包含至少一种选自指定的甘氨酸衍生物及其盐的化合物和指定的氨基硫酸衍生物及其盐。 此外，提供了包含这些化合物的外用皮肤制剂。

    WRINKLE-IMPROVING AGENT
    4.
    发明申请
    WRINKLE-IMPROVING AGENT 审中-公开
    缠绕剂改性剂

    公开(公告)号：US20120165409A1

    公开(公告)日：2012-06-28

    申请号：US13410612

    申请日：2012-03-02

    申请人： Mikiko Kaminuma ,  Masaru Suetsugu ,  Makoto Tsunenaga ,  Kiyotaka Hasegawa ,  Shinji Inomata

    发明人： Mikiko Kaminuma ,  Masaru Suetsugu ,  Makoto Tsunenaga ,  Kiyotaka Hasegawa ,  Shinji Inomata

    IPC分类号： A61K31/195 ,  A61P17/00

    CPC分类号： A61K8/44 ,  A61Q19/08

    摘要： A wrinkle-improving agent that has an effect of improving wrinkles, that does not entail problems of safety or pain even when applied to the skin, and that contains a very safe substance as an active component. A discovery was made that N-benzoyl-β-alanine, other specific β-alanine derivatives, and salts thereof have a wrinkle-improving effect, whereby a wrinkle-improving agent containing as an active component one, two, or more types of compounds selected from the group composed of these specific β-alanine derivatives and the salts thereof was developed.

    摘要翻译： 具有改善皱纹的效果的皱纹改善剂，即使施用于皮肤也不会引起安全性或疼痛的问题，并且含有作为活性成分的非常安全的物质。 发现N-苯甲酰基 - 丙氨酸，其他特定的β-丙氨酸衍生物及其盐具有皱纹改善效果，由此可以提供含有一种或两种以上活性成分的皱纹改善剂 的选自由这些特异性＆amp; - 丙氨酸衍生物组成的组的化合物及其盐。

    WRINKLE-IMPROVING AGENT
    5.
    发明申请
    WRINKLE-IMPROVING AGENT 审中-公开
    缠绕剂改性剂

    公开(公告)号：US20100035881A1

    公开(公告)日：2010-02-11

    申请号：US12067267

    申请日：2006-09-15

    申请人： Mikiko Kaminuma ,  Masaru Suetsugu ,  Makoto Tsunenaga ,  Kiyotaka Hasegawa ,  Shinji Inomata

    发明人： Mikiko Kaminuma ,  Masaru Suetsugu ,  Makoto Tsunenaga ,  Kiyotaka Hasegawa ,  Shinji Inomata

    IPC分类号： A61K8/36 ,  A61K8/49 ,  A61K8/42 ,  A61K8/46 ,  A61Q19/08

    CPC分类号： A61K8/44 ,  A61Q19/08

    摘要： The invention provides a novel wrinkle-improving agent that has an effect of improving wrinkles, that does not entail problems of safety or pain even when applied to the skin, and that contains a very safe substance as an active component. A discovery was made that N-benzoyl-β-alanine, other specific β-alanine derivatives, and salts thereof have a wrinkle-improving effect, whereby a wrinkle-improving agent containing as an active component one, two, or more types of compounds selected from the group composed of these specific β-alanine derivatives and the salts thereof was developed.

    摘要翻译： 本发明提供了具有改善皱纹的效果的新型皱纹改善剂，即使施用于皮肤也不会引起安全性或疼痛的问题，并且含有作为活性成分的非常安全的物质。 发现N-苯甲酰基-β-丙氨酸，其它特定β-丙氨酸衍生物及其盐具有皱纹改善效果，由此可以提供含有作为活性成分的一种或两种以上化合物的皱纹改善剂 选自由这些特异性β-丙氨酸衍生物及其盐组成的组。

    Parakeratosis inhibitor, pore-shrinking agent and skin preparation for external use
    7.
    发明申请
    Parakeratosis inhibitor, pore-shrinking agent and skin preparation for external use 审中-公开
    角化不全抑制剂，孔收缩剂和外用皮肤制剂

    公开(公告)号：US20080269304A1

    公开(公告)日：2008-10-30

    申请号：US12010373

    申请日：2008-01-24

    申请人： Yuji Katsuta ,  Shinji Inomata

    发明人： Yuji Katsuta ,  Shinji Inomata

    IPC分类号： A61K31/197 ,  A61K31/42 ,  A61P17/00

    CPC分类号： A61K8/44 ,  A61Q1/02 ,  A61Q19/00

    摘要： It is intended to provide a substance having an effect of shrinking pores by analyzing the mechanism of making pores perceptible and compositions such as a skin preparation for external use which exerts the above effect to thereby make pores imperceptible. As means for solving these problems, there are provided a parakeratosis inhibitor and a pore-shrinking agent comprising an antagonist to an excitatory cell receptor, for example, a glutamate receptor such as N-methyl-D-aspartic acid receptor or an ATP receptor such as P2X receptor, or an agonist to an inhibitory cell receptor such as a γ-aminobutyrate receptor such as bicuculline-sensitive receptor having the Cl-channel therein or glycine receptor, as well as a skin preparation for external use aiming at inhibiting parakeratosis and a skin preparation for external use aiming at shrinking pores each containing such an antagonist to an excitatory cell receptor or an agonist to an inhibitory cell receptor as described above. Owing to the effects of inhibiting parakeratosis and shrinking pores, the skin can be maintained in a healthy state without perceptible pores.

    摘要翻译： 旨在通过分析使毛孔感觉到的机理以及诸如发挥上述作用的外用皮肤制剂的组合物从而使毛孔不能察觉而提供具有收缩毛孔效果的物质。 作为解决这些问题的手段，提供了角化不全抑制剂和包含兴奋性细胞受体的拮抗剂的孔收缩剂，例如谷氨酸受体，例如N-甲基-D-天冬氨酸受体或ATP受体 作为P2X受体或对抑制性细胞受体如γ-氨基丁酸酯受体的激动剂，例如其中具有C1通道的糖基化敏感受体或甘氨酸受体，以及旨在抑制角化不全的外用皮肤制剂，以及 用于外用的皮肤制剂，其目的在于使每个含有这种拮抗剂的孔收缩成兴奋性细胞受体或如上所述的抑制性细胞受体的激动剂。 由于抑制角化不全和收缩毛孔的作用，皮肤可以维持在健康状态，无可察觉的毛孔。

    Parakeratosis Inhibitor and Skin Preparation for External use
    8.
    发明申请
    Parakeratosis Inhibitor and Skin Preparation for External use 有权
    角化不全抑制剂和外用皮肤准备

    公开(公告)号：US20070225380A1

    公开(公告)日：2007-09-27

    申请号：US10580471

    申请日：2004-11-22

    申请人： Mikiko Kaminuma ,  Masaru Suetsugu ,  Toshii Iida ,  Shinji Inomata ,  Keiko Takada ,  Yuji Katsuta

    发明人： Mikiko Kaminuma ,  Masaru Suetsugu ,  Toshii Iida ,  Shinji Inomata ,  Keiko Takada ,  Yuji Katsuta

    IPC分类号： A61K47/12

    CPC分类号： A61K8/0212 ,  A61K8/44 ,  A61K8/466 ,  A61Q1/02 ,  A61Q19/00

    摘要： To provide a parakeratosis inhibitor, pore reducing agent and skin roughness preventing/ameliorating agent that exhibit capabilities of parakeratosis inhibition, pore reduction, skin roughness prevention/amelioration, etc., and further provide a skin preparation for external use having these capabilities. There are provide a parakeratosis inhibitor and a pore reducing agent each comprising at least one compound selected from the group consisting of a glycine derivative, an aminodicarboxylic acid derivative, an acylaminodicarboxylic acid derivative, a pyrrolidinecarboxylic acid derivative, a piperidinecarboxylic acid derivative, a hexamethyleneiminecarboxylic acid, a beta-alanine derivative and salts of these derivatives. Further, there are provided a parakeratosis inhibitor, a pore reducing agent and a skin roughness preventing/ameliorating agent each comprising at least one compound selected from the group consisting of specified glycine derivatives and salts thereof and specified aminosulfuric acid derivatives and salts thereof. Still further, there are provided skin preparations for external use comprising these compounds.

    摘要翻译： 提供表现角化不全抑制，减孔，皮肤粗糙度防止/改善等的角化不全抑制剂，减孔剂和皮肤粗糙度防止/改善剂，进一步提供具有这些能力的外用皮肤制剂。 提供了角化不全抑制剂和孔还原剂，其各自包含至少一种选自甘氨酸衍生物，氨基二羧酸衍生物，酰氨基二羧酸衍生物，吡咯烷羧酸衍生物，哌啶羧酸衍生物，六亚甲基亚氨基羧酸 ，β-丙氨酸衍生物和这些衍生物的盐。 此外，提供了分别含有选自特定的甘氨酸衍生物及其盐的化合物和规定的氨基硫酸衍生物及其盐中的至少一种化合物的角化不全抑制剂，减孔剂和皮肤粗糙度防止改善剂。 此外，提供了包含这些化合物的外用皮肤制剂。

    Anti-aging composition and collagen production promoting composition
    9.
    发明申请
    Anti-aging composition and collagen production promoting composition 审中-公开
    抗衰老组合物和胶原蛋白生成促进作用

    公开(公告)号：US20070134265A1

    公开(公告)日：2007-06-14

    申请号：US10588780

    申请日：2004-05-18

    申请人： Keiko Takada ,  Rikako Suzuki ,  Miki Guentert ,  Shinji Inomata ,  Chika Hamada ,  Takayuki Sakiguchi

    发明人： Keiko Takada ,  Rikako Suzuki ,  Miki Guentert ,  Shinji Inomata ,  Chika Hamada ,  Takayuki Sakiguchi

    IPC分类号： A61K36/06 ,  A61K31/737

    CPC分类号： A61K8/99 ,  A61Q19/08

    摘要： There are provided an anti-aging composition, a collagen production promoting composition, a collagen gel contraction promoting composition, and an integrin production promoting composition for promoting integrin production in fibroblasts/epidermal cell, which have improved collagen production promotion effect and are effective for preventing or reducing wrinkle and/or sagging caused by aging. These anti-aging composition and promoting composition comprise, as an active ingredient, a hydrogen peroxide-treated yeast hydrolysate.

    摘要翻译： 提供抗老化组合物，胶原蛋白生成促进组合物，胶原凝胶收缩促进组合物和用于促进成纤维细胞/表皮细胞中整联蛋白产生的整联蛋白生产促进组合物，其具有改善的胶原蛋白生产促进作用并且有效预防 或减少由老化引起的皱纹和/或松弛。 这些抗衰老组合物和促进组合物包含作为活性成分的过氧化氢处理的酵母水解物。