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42 条记录 (耗时 0.028 秒)

    Parakeratosis inhibitor, pore-shrinking agent and external composition for skin
    1.
    发明授权
    Parakeratosis inhibitor, pore-shrinking agent and external composition for skin 有权
    角化不全抑制剂，孔收缩剂和皮肤外用组合物

    公开(公告)号：US08937090B2

    公开(公告)日：2015-01-20

    申请号：US11920053

    申请日：2006-04-28

    申请人： Mikiko Kaminuma ,  Masaru Suetsugu ,  Toshii Iida ,  Shinji Inomata

    发明人： Mikiko Kaminuma ,  Masaru Suetsugu ,  Toshii Iida ,  Shinji Inomata

    IPC分类号： A61K31/44 ,  A61K31/135 ,  A61K31/13 ,  A61Q19/00 ,  A61K8/02 ,  A61K8/44 ,  A61K8/49 ,  A61K31/136 ,  A61K31/137 ,  A61K31/131 ,  A61Q1/02 ,  A61Q1/12

    CPC分类号： A61Q19/00 ,  A61K8/0212 ,  A61K8/44 ,  A61K8/445 ,  A61K8/447 ,  A61K8/4926 ,  A61K31/131 ,  A61K31/136 ,  A61K31/137 ,  A61Q1/02 ,  A61Q1/12

    摘要： The invention provides a parakeratosis inhibitor, pore-shrinking agent, or rough skin preventing/ameliorating agent that has a function such as parakeratosis inhibition, pore shrinkage, or rough skin-inhibition/abatement, poses no safety problems such as sensory irritation, and is very safe, and further provides an external composition for skin to which a compound having the above-mentioned function has been added. The parakeratosis inhibitor, pore-shrinking agent, or rough skin preventing/ameliorating agent comprises one or more compounds selected from the group consisting of β-alanine derivatives and salts thereof. The external composition for skin comprises the one or more compounds selected from the group consisting of β-alanine derivatives and salts thereof as the above-mentioned parakeratosis inhibitor, pore-shrinking agent, or rough skin preventing/ameliorating agent.

    摘要翻译： 本发明提供了具有角化不全抑制，孔收缩或粗糙皮肤抑制/消瘦等功能的角化不全抑制剂，孔收缩剂或粗糙皮肤防止/改善剂，不会引起感觉刺激等安全问题，而且 非常安全，并且还提供了已经添加了具有上述功能的化合物的皮肤的外用组合物。 角化不全抑制剂，孔收缩剂或粗糙皮肤防止/改善剂包含一种或多种选自β-丙氨酸衍生物及其盐的化合物。 用于皮肤的外用组合物包含一种或多种选自上述的角化不全抑制剂，毛孔收缩剂或粗糙皮肤防止/改善剂的组合物，其组合物包括β-丙氨酸衍生物及其盐。

    Agent for alleviating wrinkles
    3.
    发明授权
    Agent for alleviating wrinkles 有权
    减轻皱纹的代理

    公开(公告)号：US08173705B2

    公开(公告)日：2012-05-08

    申请号：US12530841

    申请日：2008-03-14

    申请人： Makoto Tsunenaga ,  Mikiko Kaminuma ,  Masaru Suetsugu ,  Chika Katagiri

    发明人： Makoto Tsunenaga ,  Mikiko Kaminuma ,  Masaru Suetsugu ,  Chika Katagiri

    IPC分类号： A61K31/195

    CPC分类号： A61K8/44 ,  A61K8/466 ,  A61K31/197 ,  A61Q19/08

    摘要： The present invention provides an agent for preventing and alleviating wrinkles which has excellent effects of preventing and alleviating wrinkles formed by decreased barrier function of the skin owing to aging or photo aging, that is graphic wrinkles or linear wrinkles. The agent for preventing and alleviating wrinkles consisting of one or more compounds selected from the group consisting of gamma-aminobutyric acid derivatives represented by the following formula (1) or N,N,N-trimethyl gamma-aminobutyric acid represented by the following formula (3) and salts thereof: wherein R1 and R2 independently represent any of a hydrogen atom, an alkyl group having 1 to 3 carbon atoms, a benzyloxycarbonyl group, a cyclohexyl group, a cyclohexanemethyl group, a cyclohexanecarbonyl group, a guanidino group formed with nitrogen atom in the formula (1), an ureido group formed with nitrogen atom in the formula (1), and a group represented by following formula (2). Additionally, R1 and R2 may jointly form a piperidine ring, morpholine ring, or pyrrolidine ring. Both of R1 and R2 are not simultaneously a hydrogen atom.

    摘要翻译： 本发明提供一种防止和减轻皱纹的试剂，其具有优异的防止和减轻由于老化或照片老化导致的皮肤屏障功能形成的皱纹，即图形皱纹或线状皱纹的效果。 用于预防和减轻由一种或多种选自由下式（1）表示的γ-氨基丁酸衍生物或由下式（N）表示的N，N，N-三甲基γ-氨基丁酸组成的组中的化合物组成的皱纹的试剂 3）及其盐：其中R 1和R 2独立地表示氢原子，具有1至3个碳原子的烷基，苄氧基羰基，环己基，环己烷甲基，环己烷羰基，与氮形成的胍基 式（1）中的原子，式（1）中由氮原子形成的脲基和由下式（2）表示的基团。 此外，R 1和R 2可以共同形成哌啶环，吗啉环或吡咯烷环。 R1和R2两者不同时为氢原子。

    Pyridazine derivatives, manufacturing method and related composition
    6.
    发明授权
    Pyridazine derivatives, manufacturing method and related composition 有权
    哒嗪衍生物，制备方法及相关组成

    公开(公告)号：US06395896B2

    公开(公告)日：2002-05-28

    申请号：US09736256

    申请日：2000-12-15

    申请人： Masaru Suetsugu ,  Eijiro Hara ,  Yuji Matsushita ,  Haruhiko Inoue ,  Haruo Ogawa ,  Keiko Sakai ,  Shigeru Mugikura

    发明人： Masaru Suetsugu ,  Eijiro Hara ,  Yuji Matsushita ,  Haruhiko Inoue ,  Haruo Ogawa ,  Keiko Sakai ,  Shigeru Mugikura

    IPC分类号： C07D41314

    CPC分类号： C07D237/22 ,  A61K8/49 ,  A61K2800/52 ,  A61Q1/02 ,  A61Q1/06 ,  A61Q1/10 ,  A61Q5/00 ,  A61Q5/02 ,  A61Q17/04 ,  Y10S514/844 ,  Y10S514/845 ,  Y10S514/937

    摘要： Ultraviolet absorbents and photostabilizers have an excellent absorption ability in a wide range of ultraviolet rays, and also have high stability and high safety. The ultraviolet absorbent and photostabilizer include a pyridazine derivative of the formula (1): or salts thereof. Also, described are methods for manufacturing said pyridazine derivative and/or this salts thereof comprising the process of reacting at least 10 wt % of 4,5-dichloro-3-hydroxypyridazine or 4,5-dibromo-3-hydroxypyridazine or mixtures thereof with at least 20 vol % of morpholine in reaction solution at 70° C. or higher. The ultraviolet absorbents photostabilizers include said pyridazine derivative and/or salts thereof as effective ingredient. An ultraviolet ray absorption composition and an external preparation for skin are also included.

    摘要翻译： 紫外线吸收剂和光稳定剂在广泛的紫外线中具有优异的吸收能力，并且还具有高稳定性和高安全性。 紫外线吸收剂和光稳定剂包括式（1）的哒嗪衍生物：或其盐。 还描述了制备所述哒嗪衍生物和/或其盐的方法，其包括使至少10重量％的4,5-二氯-3-羟基哒嗪或4,5-二溴-3-羟基哒嗪或其混合物与 在70℃或更高的反应溶液中至少20体积％的吗啉。 紫外线吸收剂光稳定剂包括所述哒嗪衍生物和/或其盐作为有效成分。 还包括紫外线吸收组合物和皮肤外用剂。

    External preparation for skin
    7.
    发明授权
    External preparation for skin 失效
    外用皮肤准备

    公开(公告)号：US5700784A

    公开(公告)日：1997-12-23

    申请号：US328066

    申请日：1994-10-24

    申请人： Satoshi Shinojima ,  Masaru Suetsugu ,  Yoshihiro Morikawa ,  Yuki Shibata ,  Rumiko Kaku

    发明人： Satoshi Shinojima ,  Masaru Suetsugu ,  Yoshihiro Morikawa ,  Yuki Shibata ,  Rumiko Kaku

    IPC分类号： A61K8/60 ,  A61K31/70 ,  A61Q19/00 ,  A61Q19/02 ,  A61K31/60 ,  A61K31/62

    CPC分类号： A61Q19/00 ,  A61K31/70 ,  A61K8/602 ,  A61Q17/04 ,  A61Q19/02

    摘要： An external preparation for the skin comprising at least one of the glycosides or hydroxysaliyclic acid and/or the glycosides of aliphatic esters of hydroxysalicylic acid represented by the following formula 1: ##STR1## wherein R.sub.1 represents one selected from the group consisting of saturated hydrocarbon group and an unsaturated hydrocarbon group which have 1 to 20 carbon atoms and which may be either a straight-chain or a branched chain, and one of R.sub.2 and R.sub.3 represents a sugar residue and the other hydrogen. The external preparation for the skin has an excellent whitening effect and/or an excellent skin care effect.

    摘要翻译： 用于皮肤的外用制剂，其包含由下式1表示的羟基水杨酸的脂肪酸酯的糖苷或羟基亚油酸和/或糖苷中的至少一种：其中R 1表示选自以下的一种： 饱和烃基和具有1至20个碳原子的不饱和烃基，其可以是直链或支链，R2和R3之一表示糖残基和另一个氢。 皮肤的外用制剂具有优异的美白效果和/或优异的护肤效果。

    PARAKERATOSIS INHIBITOR AND SKIN PREPARATION FOR EXTERNAL USE
    9.
    发明申请
    PARAKERATOSIS INHIBITOR AND SKIN PREPARATION FOR EXTERNAL USE 审中-公开
    PARAKERATOSIS抑制剂和皮肤外用品的制备

    公开(公告)号：US20120253064A1

    公开(公告)日：2012-10-04

    申请号：US13467254

    申请日：2012-05-09

    申请人： Mikiko Kaminuma ,  Masaru Suetsugu ,  Toshii Iida ,  Shinji Inomata ,  Keiko Takada ,  Yuji Katsuta

    发明人： Mikiko Kaminuma ,  Masaru Suetsugu ,  Toshii Iida ,  Shinji Inomata ,  Keiko Takada ,  Yuji Katsuta

    IPC分类号： C07C309/26

    CPC分类号： A61K8/0212 ,  A61K8/44 ,  A61K8/466 ,  A61Q1/02 ,  A61Q19/00

    摘要： To provide a parakeratosis inhibitor, pore reducing agent and skin roughness preventing/ameliorating agent that exhibit capabilities of parakeratosis inhibition, pore reduction, skin roughness prevention/amelioration, etc., and further provide a skin preparation for external use having these capabilities. There are provided a parakeratosis inhibitor, a pore reducing agent and a skin roughness preventing/ameliorating agent each comprising at least one compound selected from the group consisting of specified glycine derivatives and salts thereof and specified aminosulfuric acid derivatives and salts thereof. Still further, there are provided skin preparations for external use comprising these compounds.

    摘要翻译： 提供表现角化不全抑制，减孔，皮肤粗糙度防止/改善等的角化不全抑制剂，减孔剂和皮肤粗糙度防止/改善剂，进一步提供具有这些能力的外用皮肤制剂。 提供了一种角化不全抑制剂，减孔剂和皮肤粗糙度防止/改善剂，其各自包含至少一种选自指定的甘氨酸衍生物及其盐的化合物和指定的氨基硫酸衍生物及其盐。 此外，提供了包含这些化合物的外用皮肤制剂。