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1.发明申请DIAGNOSIS SYSTEM FOR DETERMINING THE BIOLOGICALLY EFFECTIVE PARATHYROID HORMONE ACTIVITY IN A SAMPLE 审中-公开用于确定样品中生物有效的PARATHYROID HORMONE活性的诊断系统公开(公告)号：US20110003311A1
公开(公告)日：2011-01-06
申请号：US12830977
申请日：2010-07-06
IPC分类号： G01N33/74
CPC分类号： G01N33/78 , G01N2333/635
摘要： Diagnosis system or immunoassay for the determination of the effective parathyroid hormone activity in a sample, and for a diagnosis and treatment of calcium metabolism disturbances, osteopathies and hyper- or hypoparathyroidisms. The parathyroid hormone activity is measured with the aid of an antibody which binds to an epitope in the region of the receptor binding structure 15 to 22 of the parathyroid hormone, and an antibody which recognises whether the amino-terminal end 1 to 3 of the parathyroid hormone is intact. The assay permits the antagonistic characteristics of some parathyroid hormone fragments to be taken into account.
摘要翻译： 用于确定样品中有效甲状旁腺激素活性的诊断系统或免疫测定，以及用于诊断和治疗钙代谢紊乱，骨病和超或甲状旁腺功能减退症的诊断系统或免疫测定。 借助于与甲状旁腺激素的受体结合结构15至22的区域中的表位结合的抗体和识别甲状旁腺的氨基末端1至3的抗体来测量甲状旁腺激素活性 激素是完整的。 该测定允许考虑一些甲状旁腺激素片段的拮抗特征。
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2.发明申请公开(公告)号：US20060211054A1
公开(公告)日：2006-09-21
申请号：US10473975
申请日：2002-04-03
CPC分类号： G01N33/74 , G01N2333/635
摘要： Method for determining the active parathyroid hormone content in a sample, wherein the component of parathyroid hormone polypeptide chains which are oxidized at one or more sites near the PTH receptor binding structure having the amino acids 15 to 22 are specifically excluded from the content determination. Oxidation of the parathyroid hormone occurs in particular in dialysis patients, their blood plasma being exposed to an oxidation stress in the dialysis. The invention is based on the use of antibodies which bind specific conformation epitopes of the oxidised or reduced parathyroid hormone and its fragments. Further, there is provided a test system for the quantitative determination of parathyroid hormone and active fragments hereof in a sample.
摘要翻译： 用于测定样品中活性甲状旁腺激素含量的方法，其中在具有氨基酸15至22的PTH受体结合结构附近的一个或多个位点处氧化的甲状旁腺激素多肽链的组分被特异性排除在内容确定之外。 甲状旁腺激素的氧化特别是在透析患者中发生，其血浆在透析中暴露于氧化应激。 本发明基于使用结合氧化或还原的甲状旁腺激素及其片段的特异性构象表位的抗体。 此外，提供了用于在样品中定量测定甲状旁腺激素及其活性片段的测试系统。
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3.发明授权Method for determining the biologically effective parathyroid hormone activity in a sample 有权确定样品中生物学有效的甲状旁腺激素活性的方法公开(公告)号：US07851163B2
公开(公告)日：2010-12-14
申请号：US10168185
申请日：2000-12-18
IPC分类号： G01N33/53
CPC分类号： G01N33/78 , G01N2333/635
摘要： Immunoassay for the determination of parathyroid hormone activity in a sample, and for the diagnosis, etiology and treatment of calcium metabolism disturbances, osteopathies and hyper- or hypoparathyroidisms. The parathyroid hormone activity is measured with the aid of an antibody which binds to an epitope in the region of the receptor binding structure 15 to 22 of the parathyroid hormone, and an antibody which recognizes whether the amino-terminal end 1 to 3 of the parathyroid hormone is intact. The assay permits the antagonistic characteristics of some parathyroid hormone fragments to be taken into account.
摘要翻译： 用于测定样品中甲状旁腺激素活性的免疫测定，以及钙代谢紊乱，骨病和超或甲状旁腺功能亢进症的诊断，病因和治疗。 借助于与甲状旁腺激素的受体结合结构15至22的区域中的表位结合的抗体和识别甲状旁腺的氨基末端1至3的抗体来测量甲状旁腺激素活性 激素是完整的。 该测定允许考虑一些甲状旁腺激素片段的拮抗特征。
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4.发明授权公开(公告)号：US07790398B2
公开(公告)日：2010-09-07
申请号：US10473975
申请日：2002-04-03
IPC分类号： G01N33/53
CPC分类号： G01N33/74 , G01N2333/635
摘要： Method for determining the active parathyroid hormone content in a sample, wherein the component of parathyroid hormone polypeptide chains which are oxidized at one or more sites near the PTH receptor binding structure having the amino acids 15 to 22 are specifically excluded from the content determination. Oxidation of the parathyroid hormone occurs in particular in dialysis patients, their blood plasma being exposed to an oxidation stress in the dialysis. The invention is based on the use of antibodies which bind specific conformation epitopes of the oxidised or reduced parathyroid hormone and its fragments. Further, there is provided a test system for the quantitative determination of parathyroid hormone and active fragments hereof in a sample.
摘要翻译： 用于测定样品中活性甲状旁腺激素含量的方法，其中在具有氨基酸15至22的PTH受体结合结构附近的一个或多个位点处氧化的甲状旁腺激素多肽链的组分被特异性排除在内容确定之外。 甲状旁腺激素的氧化特别是在透析患者中发生，其血浆在透析中暴露于氧化应激。 本发明基于使用结合氧化或还原的甲状旁腺激素及其片段的特异性构象表位的抗体。 此外，提供了用于在样品中定量测定甲状旁腺激素及其活性片段的测试系统。
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