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公开(公告)号：US08935958B2
公开(公告)日：2015-01-20
申请号：US13300399
申请日：2011-11-18
Applicant: Warren James Downing
Inventor： Warren James Downing
Abstract: Embodiments of the present technology are directed to systems and methods for measuring projectile muzzle velocity. A muzzle velocity sensor measures an acceleration as well as a set of events occurring within the barrel of the firearm upon a shot being fired. Using the measured data, a muzzle velocity is calculated. The muzzle velocity sensor is used externally to the firearm, requiring no changes to the firearm or the projectile.
Abstract translation: 本技术的实施例涉及用于测量弹丸枪口速度的系统和方法。 枪口速度传感器在射击被射击时测量加速度以及枪支枪管内发生的一系列事件。 使用测量数据，计算枪口速度。 枪口速度传感器在枪支外部使用，不需要更改枪支或射弹。
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公开(公告)号：US20100134383A1
公开(公告)日：2010-06-03
申请号：US12315031
申请日：2008-11-28
Applicant: Jeffrey Paul Mele , Gregory James Downing
Inventor： Jeffrey Paul Mele , Gregory James Downing
IPC: G09G5/12
CPC classification number: G09G3/28 , G09G2300/026
Abstract: A Plasma Video Scoreboard is an assembly of multiple plasma video display units to create one or multiple images, larger in surface area than any single plasma video display on the market, and is assembled with the intended capability to simultaneously displays live and pre-recorded video, advertising, player information, sports statistics, time clocks, and score for sports events. A Plasma Video Scoreboard is a melding of plasma video display technology with the conventional structure of a scoreboard.
Abstract translation: 等离子视频记分板是多个等离子体视频显示单元的组合，用于创建一个或多个图像，比市面上的任何一个等离子体视频显示器更大的表面积，并且具有同时显示实时和预录视频的预期能力 ，广告，玩家信息，体育统计，时钟和体育赛事得分。 等离子视频记分板是等离子视频显示技术与记分板的传统结构的融合。
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公开(公告)号：US08988582B2
公开(公告)日：2015-03-24
申请号：US13368428
申请日：2012-02-08
Applicant: Ewan Findlay , James Downing , Andrew Murray , Lindsay Grant , Adam Caley
Inventor： Ewan Findlay , James Downing , Andrew Murray , Lindsay Grant , Adam Caley
CPC classification number: H04N5/2254 , G02B3/0043 , G02B3/0056 , H04N5/3415
Abstract: An image sensor includes a pixel array and an image sensor objective optical element. The element is formed by a lenslet array. Each lenslet in the array directs incoming radiation onto a different specific pixel or sub-array of pixels in the pixel array. The lenslets in the array are shaped such that fields of view of next-but-one neighboring ones of the lenslets (i.e., two lenslets spaced from each other by another lenslet) do not overlap until a certain object distance away from the lenslet array.
Abstract translation: 图像传感器包括像素阵列和图像传感器物镜光学元件。 元件由小透镜阵列形成。 阵列中的每个小透镜将入射辐射引导到像素阵列中的不同特定像素或像素子阵列上。 阵列中的小透镜被成形为使得相邻的小透镜（即，由另一个小透镜彼此间隔开的两个小透镜）的相邻但相邻的视角的视场不重叠，直到远离微透镜阵列的某个物体距离。
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公开(公告)号：US20060142468A1
公开(公告)日：2006-06-29
申请号：US11025183
申请日：2004-12-29
Applicant: James Downing , Kenji Nagai , Makoto Nagase , Katsuhiko Nakazato
Inventor： James Downing , Kenji Nagai , Makoto Nagase , Katsuhiko Nakazato
IPC: C08L27/12
CPC classification number: C08K7/22 , Y10T428/2982 , C08L27/18
Abstract: The present invention is a composition that includes granular-grade polytetrafluoroethylene and a plurality of microspheres, where the plurality of microspheres have an average specific gravity less than about 0.9 grams per cubic centimeter.
Abstract translation: 本发明是包含粒状聚四氟乙烯和多个微球的组合物，其中多个微球的平均比重小于约0.9克/立方厘米。
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公开(公告)号：US20050204457A1
公开(公告)日：2005-09-22
申请号：US11121448
申请日：2005-05-04
Applicant: Mark Stiles , Alan Wilcox , James Downing , Samuel Tidwell , Steve Caldwell
Inventor： Mark Stiles , Alan Wilcox , James Downing , Samuel Tidwell , Steve Caldwell
CPC classification number: A42B3/0473 , A41D13/0512 , B60R22/001 , B64D10/00 , F16B21/09 , Y10T24/45597 , Y10T24/4599 , Y10T29/4984
Abstract: A post attachment device for connecting a helmet to a head and neck support. The device includes a post anchor having a base, a button, a resilient member, a post, a retainer and a catch having a slot with a larger first section connected by a channel to a smaller second section. The button is positioned in an indention in the base with the resilient member positioned therebetween. The post extends through the button, the base and the helmet. The retainer is secured on the post adjacent the inner surface of the helmet. To secure the post attachment device, the catch is orientated over the post. The button is then pressed into the base while the catch is moved backwards to move the post into the second section of the slot.
Abstract translation: 一种用于将头盔连接到头颈部支撑件的后附接装置。 该装置包括具有底座，按钮，弹性构件，柱，保持器和具有狭槽的支柱锚，该槽具有较大的第一部分，该第一部分通过通道连接到较小的第二部分。 该按钮位于基座中的一个凹口中，其中弹性构件位于它们之间。 该柱延伸穿过按钮，基座和头盔。 保持器固定在邻近头盔内表面的柱上。 为了固定柱附件装置，捕获物定向在柱上。 然后将按钮压入基座，同时将卡扣向后移动以将柱移动到槽的第二部分中。
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Patent Agency Ranking
公开(公告)号：US20060090311A1
公开(公告)日：2006-05-04
申请号：US11311492
申请日：2005-12-19
Applicant: James Downing , Samuel Tidwell , Steve Caldwell
Inventor： James Downing , Samuel Tidwell , Steve Caldwell
IPC: A44B11/25
CPC classification number: A42B3/0473 , A41D13/0512 , F16B21/09 , Y10T24/2536 , Y10T24/45597 , Y10T24/4599 , Y10T29/49716 , Y10T29/4984 , Y10T29/49947 , Y10T29/49948 , Y10T29/49963 , Y10T29/49995
Abstract: A post attachment device for connecting a helmet to a head and neck support. The device includes a post anchor having a base, a button, a resilient member, a post, a retainer and a catch having a slot with a larger first section connected by a channel to a smaller second section. The button is positioned in an indention in the base with the resilient member positioned therebetween. The post extends through the button, the base and the helmet. The retainer is secured on the post adjacent the inner surface of the helmet. To secure the post attachment device, the catch is orientated over the post. The button is then depressed into the base while the catch is moved backwards to move the post into the second section of the slot.
Abstract translation: 一种用于将头盔连接到头颈部支撑件的后附接装置。 该装置包括具有底座，按钮，弹性构件，柱，保持器和具有狭槽的支柱锚，该槽具有较大的第一部分，该第一部分通过通道连接到较小的第二部分。 该按钮位于基座中的一个凹口中，其中弹性构件位于它们之间。 该柱延伸穿过按钮，基座和头盔。 保持器固定在邻近头盔内表面的柱上。 为了固定柱附件装置，捕获物定向在柱上。 然后将按钮压入基座，同时将卡扣向后移动以将柱移动到槽的第二部分中。
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7.发明申请METHODS AND COMPOSITIONS FOR THE DIAGNOSIS AND TREATMENT OF ACUTE LYMPHOBLASTIC LEUKEMIA 审中-公开急性淋巴细胞白血病诊断和治疗方法与组合公开(公告)号：US20110047634A1
公开(公告)日：2011-02-24
申请号：US12866511
申请日：2009-02-04
Applicant: James Downing , Charles Mullighan
Inventor： James Downing , Charles Mullighan
CPC classification number: C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/178 , G01N33/5011 , G01N33/57426
Abstract: Compositions and methods for the identification, prognosis, classification, diagnosis, and treatment of leukemia or a genetic predisposition to leukemia are provided. The present invention is based on the discovery of a novel intragenic deletion in the v-ets erythroblastosis virus E26 oncogene homolog (ERG) allele which is shown herein to be associated with a novel subtype of B-progenitor acute lymphoblastic leukemia (ALL). In one embodiment, the intragenic deletion in ERG results in the expression of C-terminal domain deletion forms of the ERG polypeptide which lacks the DNA-binding PNT domain and CAE domain of the ERG polypeptide and have dominant negative ERG activity. In other embodiments, the intragenic deletions results in a loss of expression of the native ERG polypeptide. Such nucleotide sequences and amino acid sequences of ERG find use in methods and compositions useful in the identification and/or the prognosis and/or predisposition and/or treatment of ALL, more particularly, the novel subtype of B-progenitor AL.
Abstract translation: 提供了鉴定，预后，分类，诊断和治疗白血病或白血病遗传倾向的组合物和方法。 本发明基于在本文显示与B-祖细胞急性淋巴细胞白血病（ALL）的新亚型相关的v-ets成红细胞增生病毒E26致癌基因同源物（ERG）等位基因中发现新的基因缺失。 在一个实施方案中，ERG中的基因内缺失导致缺少ERG多肽的DNA结合PNT结构域和CAE结构域并且具有显性负ERG活性的ERG多肽的C末端结构域缺失形式的表达。 在其他实施方案中，基因内缺失导致天然ERG多肽的表达丧失。 ERG的这种核苷酸序列和氨基酸序列可用于鉴定和/或预测和/或倾向和/或治疗ALL，尤其是B型祖细胞AL的新亚型的方法和组合物。
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8.发明申请METHODS AND COMPOSITIONS FOR THE DIAGNOSIS AND TREATMENT OF CHRONIC MYELOID LEUKEMIA AND ACUTE LYMPHOBLASTIC LEUKEMIA 审中-公开慢性髓性白血病和急性淋巴细胞白血病诊断和治疗的方法和组合公开(公告)号：US20100240057A1
公开(公告)日：2010-09-23
申请号：US12738759
申请日：2008-11-06
Applicant: James Downing , Charles Mullighan
Inventor： James Downing , Charles Mullighan
IPC: C12Q1/68
CPC classification number: C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136
Abstract: Compositions and methods for the identification, prognosis, classification, treatment, and diagnosis of leukemia or a genetic predisposition to leukemia are provided. The present invention is based on the discovery of various genomic abnormalities of the IKZFl gene which are shown herein to be associated with acute lymphoblastic leukemia (ALL), more particularly, associated with BCR-ABL1 positive ALL and/or shown to be associated with chronic myeloid leukemia (CML), more particularly, associated with blast crisis chronic myeloid leukemia (BC-CML) and/or the likelihood of progression into blastic transformation of CML. These various genomic abnormalities of the IKZFl gene can further be used as prognostic markers to identify a subgroup of ALL having very poor outcomes. Such genomic abnormalities of IKZFl find use in methods and compositions useful in the identification and/or prognosis and/or predisposition and/or treatment of ALL, more particularly, BCR-ABL1 positive ALL and/or in the identification and/or prognosis and/or predisposition and/or treatment of CML, more particularly, of BC-CML and/or the likelihood of progression into blastic transformation of CML and/or as prognostic markers to identify a subgroup of ALL having very poor outcomes.
Abstract translation: 提供了用于鉴定，预后，分类，治疗和诊断白血病或白血病遗传倾向的组合物和方法。 本发明基于IKZF1基因的各种基因组异常的发现，本文显示与急性成淋巴细胞白血病（ALL）相关，特别是与BCR-ABL1阳性ALL相关和/或显示与慢性淋巴细胞白血病 骨髓性白血病（CML），更特别是与爆发性危机慢性骨髓性白血病（BC-CML）相关和/或进展为CML变性的可能性。 IKZF1基因的这些各种基因组异常可进一步用作预后标记，以鉴定具有非常差的结果的ALL亚组。 IKZF1的这种基因组异常发现可用于鉴定和/或预后和/或倾向和/或治疗ALL，特别是BCR-ABL1阳性ALL和/或鉴定和/或预后和/ 或倾向和/或治疗CML，更特别是BC-CML和/或进展为CML和/或作为预后标志物的急性转化的可能性以鉴定具有非常差的结果的ALL亚组。
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公开(公告)号：US20120206620A1
公开(公告)日：2012-08-16
申请号：US13368428
申请日：2012-02-08
Applicant: Ewan Findlay , James Downing , Andrew Murray , Lindsay Grant , Adam Caley
Inventor： Ewan Findlay , James Downing , Andrew Murray , Lindsay Grant , Adam Caley
CPC classification number: H04N5/2254 , G02B3/0043 , G02B3/0056 , H04N5/3415
Abstract: An image sensor includes a pixel array and an image sensor objective optical element. The element is formed by a lenslet array. Each lenslet in the array directs incoming radiation onto a different specific pixel or sub-array of pixels in the pixel array. The lenslets in the array are shaped such that fields of view of next-but-one neighboring ones of the lenslets (i.e., two lenslets spaced from each other by another lenslet) do not overlap until a certain object distance away from the lenslet array.
Abstract translation: 图像传感器包括像素阵列和图像传感器物镜光学元件。 元件由小透镜阵列形成。 阵列中的每个小透镜将入射辐射引导到像素阵列中的不同特定像素或像素子阵列上。 阵列中的小透镜被成形为使得相邻的小透镜（即，由另一个小透镜彼此间隔开的两个小透镜）的相邻但相邻的视角的视场不重叠，直到远离微透镜阵列的某个物体距离。
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公开(公告)号：US20120125092A1
公开(公告)日：2012-05-24
申请号：US13300399
申请日：2011-11-18
Applicant: Warren James Downing
Inventor： Warren James Downing
IPC: G01L5/14
Abstract: Embodiments of the present technology are directed to systems and methods for measuring projectile muzzle velocity. A muzzle velocity sensor measures an acceleration as well as a set of events occurring within the barrel of the firearm upon a shot being fired. Using the measured data, a muzzle velocity is calculated. The muzzle velocity sensor is used externally to the firearm, requiring no changes to the firearm or the projectile.
Abstract translation: 本技术的实施例涉及用于测量弹丸枪口速度的系统和方法。 枪口速度传感器在射击被射击时测量加速度以及枪支枪管内发生的一系列事件。 使用测量数据，计算枪口速度。 枪口速度传感器在枪支外部使用，不需要更改枪支或射弹。
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