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1.发明申请Delivery of drugs from sustained release devices implanted in myocardial tissue or in the pericardial space 审中-公开从植入心肌组织或心包空间的持续释放装置递送药物公开(公告)号：US20080095824A1
公开(公告)日：2008-04-24
申请号：US11975181
申请日：2007-10-17
IPC分类号： A61K9/00 , A61K31/56 , A61P9/00 , A61K31/573
CPC分类号： A61K9/0024 , A61B2017/00247 , A61B2018/00392 , A61F2/2493 , A61F2210/0004 , A61K9/0019 , A61K9/0092 , A61K9/12 , A61K9/1647 , A61K9/7015 , A61K47/14 , A61K47/26 , A61K47/34 , A61M1/10 , A61M31/002 , A61M2205/04 , A61M2210/122
摘要： The present invention provides delivery of drugs to the heart or cardiac vasculature using fully implanted sustained-release dosage forms.
摘要翻译： 本发明使用完全植入的缓释剂型将药物递送至心脏或心脏血管。
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2.发明授权System, apparatus, and method for reproducible and comparable flow acquisitions 有权用于可重复和可比较的流量采集的系统，装置和方法公开(公告)号：US08340744B2
公开(公告)日：2012-12-25
申请号：US12096995
申请日：2006-12-08
申请人： Joerg Bredno , Alexandra Groth , Juergen Weese , Antonius Johannes Cornelius Bruijns , Peter Maria Johannes Rongen , Ronaldus Petrus Johannes Hermans , Heidrun Steinhauser
发明人： Joerg Bredno , Alexandra Groth , Juergen Weese , Antonius Johannes Cornelius Bruijns , Peter Maria Johannes Rongen , Ronaldus Petrus Johannes Hermans , Heidrun Steinhauser
CPC分类号： G01R33/5635 , A61B5/0275 , A61B5/0456 , A61B6/481 , A61B6/504 , A61B6/507 , A61B8/06 , A61M5/007 , A61M5/1723 , A61M2230/04 , G01R33/281 , G01R33/5601 , G06T7/0012 , G06T7/20 , G06T2207/30101
摘要： A system, apparatus and method are provided for measuring and removing the influence of pulsatility on contrast agent flow in a region of interest of a vascular system of a patient. Once the change of blood speed over the cardiac cycle is known (pulsatility), this influence is removed from acquired image sequence for outcome control such that “quasi-stationary”, regular flow acquisition is passed on to subsequent visualization and analysis processes. A contrast agent injector is also provided that simultaneously measures and uses ECG to inject a known contrast agent at a fixed point over the cardiac cycle or such that a known amount of contrast agent will arrive at a known time at a region of interest in the vasculature of a patient, thus controlling one of the main unwanted variables in an acquisition of blood flow sequences.
摘要翻译： 提供了一种系统，装置和方法，用于测量和消除脉搏对患者血管系统感兴趣区域中造影剂流动的影响。 一旦知道了心脏周期的血液速度变化（脉动），这种影响就从获得的结果控制图像序列中消除，从而使准静态，常规流动获取传递到随后的可视化和分析过程。 还提供造影剂注射器，其同时测量并使用ECG在心脏周期上的固定点注入已知的造影剂，或使已知量的造影剂在脉管系统中的感兴趣区域的已知时间到达 因此在获取血流序列时控制主要不需要的变量之一。
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公开(公告)号：US20120321156A1
公开(公告)日：2012-12-20
申请号：US13582124
申请日：2011-03-04
IPC分类号： G06K9/00
CPC分类号： G06T7/2053 , A61B6/4441 , A61B6/4464 , A61B6/503 , A61B6/504 , A61B6/5235 , A61B6/5288 , G06T7/254 , G06T2207/10121 , G06T2207/30048 , G06T2207/30101
摘要： A method and an apparatus for motion visualization of a moving object in angiographic images are described. In a preferred embodiment of the method, first a mask image of the object of interest is acquired and a sequence of angiographic images of the object in different phases of motion of the object is acquired. Then, a first angiographic subtraction image and at least a second angiographic subtraction image are generated by subtracting the angiographic images from the mask image. Subsequently, a twice subtracted image is generated by subtracting the first angiographic subtraction image from the second angiographic subtraction image. In this way a double subtraction, i.e. a twice subtracted angiography is performed, to facilitate the assessment of the motion.
摘要翻译： 描述了用于血管造影图像中的移动物体的运动可视化的方法和装置。 在该方法的优选实施例中，首先获取感兴趣对象的掩模图像，并且获取对象在运动对象的不同阶段中的血管造影图像序列。 然后，通过从掩模图像中减去血管造影图像来生成第一血管造影减影图像和至少第二血管造影减影图像。 随后，通过从第二血管造影减影图像中减去第一血管造影减影图像来产生两倍的减影图像。 以这种方式，执行双减法，即进行两次减去的血管造影术，以便于评估运动。
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4.发明授权System and method for predicting physical properties of an aneurysm from a three-dimensional model thereof 有权用于从其三维模型预测动脉瘤的物理性质的系统和方法公开(公告)号：US07865001B2
公开(公告)日：2011-01-04
申请号：US11721386
申请日：2005-12-14
IPC分类号： G06K9/00
CPC分类号： A61B6/504 , A61B5/02014 , A61B5/1076 , A61B6/466 , G16H50/50
摘要： A three-dimensional rotational angiography (3DRA) system, in which a finite element method (FEM) package is incorporated which can read in surface meshes (20b) of a reconstructed 3DRA image of an aneurysm to generate FEM meshes (20a) which are closely approximated to the observed aneurysm (20b) in an iterative process by changing the material properties of the aneurysm used in generating the simulated representations (20a) thereof. Thus, the material properties of the closely approximated simulated representation (20a) can be used in subsequent analysis of the physical properties of the aneurysm under consideration.
摘要翻译： 一种三维旋转血管造影（3DRA）系统，其中结合有限元法（FEM）包，其可以在动脉瘤的重建的3DRA图像的表面网格（20b）中读取以产生紧密的FEM网格（20a） 通过改变在生成其模拟表示（20a）中使用的动脉瘤的材料特性，在迭代过程中近似于观察到的动脉瘤（20b）。 因此，近似模拟表示（20a）的材料性质可用于随后分析所考虑的动脉瘤的物理性质。
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公开(公告)号：USD549091S1
公开(公告)日：2007-08-21
申请号：US29232774
申请日：2005-06-24
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公开(公告)号：US09025840B2
公开(公告)日：2015-05-05
申请号：US13582124
申请日：2011-03-04
CPC分类号： G06T7/2053 , A61B6/4441 , A61B6/4464 , A61B6/503 , A61B6/504 , A61B6/5235 , A61B6/5288 , G06T7/254 , G06T2207/10121 , G06T2207/30048 , G06T2207/30101
摘要： A method and an apparatus for motion visualization of a moving object in angiographic images are described. In a preferred embodiment of the method, first a mask image of the object of interest is acquired and a sequence of angiographic images of the object in different phases of motion of the object is acquired. Then, a first angiographic subtraction image and at least a second angiographic subtraction image are generated by subtracting the angiographic images from the mask image. Subsequently, a twice subtracted image is generated by subtracting the first angiographic subtraction image from the second angiographic subtraction image. In this way a double subtraction, i.e. a twice subtracted angiography is performed, to facilitate the assessment of the motion.
摘要翻译： 描述了用于血管造影图像中的移动物体的运动可视化的方法和装置。 在该方法的优选实施例中，首先获取感兴趣对象的掩模图像，并且获取对象在运动对象的不同阶段中的血管造影图像序列。 然后，通过从掩模图像中减去血管造影图像来生成第一血管造影减影图像和至少第二血管造影减影图像。 随后，通过从第二血管造影减影图像中减去第一血管造影减影图像来产生两倍的减影图像。 以这种方式，执行双减法，即进行两次减去的血管造影术，以便于评估运动。
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7.发明申请SYSTEM AND METHOD FOR PREDICTING PHYSICAL PROPERTIES OF AN ANEURYSM FROM A THREE-DIMENSIONAL MODEL THEREOF 有权用于预测其三维模型的ANEURYSM的物理特性的系统和方法公开(公告)号：US20090238420A1
公开(公告)日：2009-09-24
申请号：US11721386
申请日：2005-12-14
IPC分类号： G06K9/00
CPC分类号： A61B6/504 , A61B5/02014 , A61B5/1076 , A61B6/466 , G16H50/50
摘要： A three-dimensional rotational angiography (3DRA) system, in which a finite element method (FEM) package is incorporated which can read in surface meshes (20b) of a reconstructed 3DRA image of an aneurysm to generate FEM meshes (20a) which are closely approximated to the observed aneurysm (20b) in an iterative process by changing the material properties of the aneurysm used in generating the simulated representations (20a) thereof. Thus, the material properties of the closely approximated simulated representation (20a) can be used in subsequent analysis of the physical properties of the aneurysm under consideration.
摘要翻译： 一种三维旋转血管造影（3DRA）系统，其中结合有限元法（FEM）包，其可以在动脉瘤的重建的3DRA图像的表面网格（20b）中读取以产生紧密的FEM网格（20a） 通过改变在生成其模拟表示（20a）中使用的动脉瘤的材料特性，在迭代过程中近似于观察到的动脉瘤（20b）。 因此，近似模拟表示（20a）的材料性质可用于随后分析所考虑的动脉瘤的物理性质。
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公开(公告)号：US20080310932A1
公开(公告)日：2008-12-18
申请号：US11794097
申请日：2005-12-21
申请人： Dale Michael McIntyre , James Malcolm Buchanan , Shane Robert Reckin , Henricus Jacobus Johannes Hermans
发明人： Dale Michael McIntyre , James Malcolm Buchanan , Shane Robert Reckin , Henricus Jacobus Johannes Hermans
IPC分类号： F16B39/24
CPC分类号： B29C70/80 , F16B43/001
摘要： A washer adapted to minimise contamination by avoiding in use inappropriate crevices. metal annular disc having an annular rebate on at least one face to its outer periphery, and a unitary formation of a flexible medium (e.g. of a food grade rubber) (A) preferably more than filling the or each rebate and (B) surrounding the outer periphery of the disc.
摘要翻译： 适用于通过避免使用不当裂缝来最大限度减少污染的洗衣机。 金属环形盘在其至少一个外表面上具有环形凹槽，以及柔性介质（例如食品级橡胶）（A）的整体形成（A）优选地不是填充或每个回扣，而且（B）围绕 盘的外围。
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公开(公告)号：US20060079383A1
公开(公告)日：2006-04-13
申请号：US11262457
申请日：2005-10-28
申请人： Johannes Hermans
发明人： Johannes Hermans
CPC分类号： A63B21/0603 , A63B21/072 , A63B2071/0625 , F16B7/0433
摘要： A training tool comprising an elongate hollow space enclosed by a holder, which hollow space is partly filled with an amount of freely movable particles, the particles being configured to provide a reactive impact when the particles collide during acceleration and deceleration.
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公开(公告)号：US5429838A
公开(公告)日：1995-07-04
申请号：US131851
申请日：1993-10-05
申请人： Per Mansson , Johannes Hermans
发明人： Per Mansson , Johannes Hermans
CPC分类号： B29D11/00865 , B29L2011/0016
摘要： In a method for producing intraocular lenses with improved optical properties, applying to the optical part of the lens a coating to protect the surface during one or more processing steps which are carried out under conditions so that the protective coating is essentially insoluble and remains adhered to the lens, and removing the coating by changing the conditions which make the coating adhere to the lens.
摘要翻译： 在用于生产具有改善的光学性质的眼内透镜的制造方法中，在一个或多个加工步骤期间，将镜片的光学部件涂覆到一个或多个加工步骤中以保护表面的涂层，所述加工步骤在保护涂层基本上不溶和保持粘附的条件下进行 透镜，并通过改变使涂层粘附到透镜上的条件来去除涂层。
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