公开(公告)号：US20240298913A1

公开(公告)日：2024-09-12

申请号：US18573695

申请日：2022-06-24

Applicant: PERFUSION TECH APS

Inventor： Mads Holst Aagaard Madsen ,  Morten Asp Vonsild Lund ,  Erik Bærentsen

IPC: A61B5/0275 ,  A61B5/00 ,  A61B5/026 ,  G06T7/00 ,  G06V10/25 ,  G06V10/764

CPC classification number: A61B5/0275 ,  A61B5/0071 ,  A61B5/0261 ,  A61B5/489 ,  G06T7/0014 ,  G06V10/25 ,  G06V10/764 ,  G06T2207/10064 ,  G06T2207/20092 ,  G06T2207/30101 ,  G06V2201/03

Abstract: Disclosed are systems and methods for continuously detecting, and optionally classifying, abnormal perfusion patterns in tissue by means of fluorescence imaging. A computer implemented method for detecting (and/or identifying) one or more areas having an abnormal perfusion pattern in tissue of a subject, for example during a medical procedure, includes: continuously acquiring fluorescence images of the tissue, wherein the fluorescence images are associated with a fluorescent output signal correlated with an input signal defined by a series of boluses of at least one fluorescent imaging agent, and wherein the series of boluses is administered with a predefined and/or controlled duration between subsequent boluses, analyzing the fluorescence images, identifying at least one tissue area with normal perfusion, defining a normal perfusion pattern (in an intensity domain and) in a time domain, and detecting, in the fluorescence images, possible tissue areas with abnormal (non-normal) perfusion pattern.

公开(公告)号：US12036011B2

公开(公告)日：2024-07-16

申请号：US16859842

申请日：2020-04-27

Applicant: Stryker Corporation

Inventor： Robert W. Flower ,  Robert Anthony Stead ,  Arthur E. Bailey

IPC: A61B5/026 ,  A61B5/00 ,  A61B5/0275 ,  A61B5/0295

CPC classification number: A61B5/0261 ,  A61B5/0071 ,  A61B5/0275 ,  A61B5/0295 ,  A61B5/00 ,  A61B5/6826

Abstract: A method, an apparatus, and a kit including the apparatus and a fluorescence agent are provided for measuring a time-varying change in an amount of blood in a tissue volume, and include exciting a fluorescence agent in the blood, acquiring a time-varying light intensity signal during a pulsatile flow of the blood through the tissue volume, the pulsatile flow having a systolic and a diastolic phase resembling a conventional photoplethysmogram, and processing the acquired signal by applying a modified Beer-Lambert law to obtain a measurement of the time-varying change in the amount of blood in the tissue volume. The instantaneous molar concentration of the fluorescence agent is determined by utilizing a concentration-mediated change in a fluorescence emission spectrum of the fluorescence agent. There is further provided a fluorescence agent for use in the method.

公开(公告)号：US11980735B2

公开(公告)日：2024-05-14

申请号：US16534725

申请日：2019-08-07

Applicant: Wisconsin Alumni Research Foundation

Inventor： Erick Louis Oberstar ,  Michael Antonio Speidel

IPC: A61M5/00 ,  A61B5/026 ,  A61B5/0275 ,  A61B6/00 ,  A61B6/03 ,  A61B6/50 ,  A61B8/06 ,  A61B8/08 ,  A61M5/14 ,  A61M5/145

CPC classification number: A61M5/007 ,  A61B6/481 ,  A61B6/507 ,  A61M5/1408 ,  A61M5/1452 ,  A61B5/0263 ,  A61B5/0275 ,  A61B6/032 ,  A61B8/06 ,  A61B8/481 ,  A61M2205/3334 ,  A61M2230/04

Abstract: Aspects of the disclosure are directed to methods and/or apparatuses involving modifying flow and/or concentration of an agent being injected for characterizing a vascular system. As may be implemented in accordance with one or more embodiments, a liquid including an agent is injected into a vascular system, by dynamically modulating a flow rate of the agent being injected over a range of flow rates. The vascular system is characterized based on a response of the vascular system to the dynamic modulation. In some implementations, such an approach involves using an injector that operates to separately control the rate at which an agent and other liquid such as saline are injected. These approaches can be implemented with modulation schemes using one or more of a variety of functions.

公开(公告)号：US11826137B2

公开(公告)日：2023-11-28

申请号：US17323257

申请日：2021-05-18

Applicant: Piccolo Medical Inc.

Inventor： Alexey Salamini ,  Eric Yu ,  Daniel R. Burnett

IPC: A61B5/00 ,  A61B5/06 ,  A61M25/01 ,  A61B5/283 ,  A61B5/29 ,  A61B5/0275 ,  A61B5/01 ,  A61B5/028 ,  A61M25/00 ,  A61M25/09 ,  A61B7/02 ,  A61B8/12

CPC classification number: A61B5/065 ,  A61B5/0008 ,  A61B5/01 ,  A61B5/028 ,  A61B5/0275 ,  A61B5/068 ,  A61B5/283 ,  A61B5/29 ,  A61M25/0026 ,  A61M25/0102 ,  A61M25/0105 ,  A61B5/6851 ,  A61B5/6852 ,  A61B5/7239 ,  A61B7/023 ,  A61B8/12 ,  A61M2025/0166 ,  A61M2025/09175

Abstract: Devices and methods for vascular navigation, assessment and/or diagnosis are described which determine the location of the tip of a vascular catheter using the introduction of a medium with a measurable parameter (e.g., temperature, light reflection, sound reflection, etc.) and sensing and measuring the measurable parameter as the catheter is advanced. Measurements of the parameter are tracked over time, recorded and analyzed. The value of the parameter and/or the shape of the parameter value vs. time curve may be used in the analysis. For example, curve amplitude, variability, standard deviation, slope, etc. may be used in the analysis of catheter location.

公开(公告)号：US20230355121A1

公开(公告)日：2023-11-09

申请号：US18353837

申请日：2023-07-17

Applicant: Stryker European Operations Limited

Inventor： Robert W. FLOWER ,  Robert Anthony STEAD ,  Arthur E. BAILEY

IPC: A61B5/026 ,  A61B5/0275 ,  A61B5/029 ,  A61B5/00 ,  A61B5/024

CPC classification number: A61B5/0261 ,  A61B5/0275 ,  A61B5/029 ,  A61B5/0071 ,  A61B5/02416 ,  A61B5/6826

Abstract: Methods and systems for facilitating assessment of blood flow in a tissue volume of a subject are disclosed. In some variations, the method may include: after a predetermined amount of a fluorescence agent has been administered to the subject, exciting the fluorescence agent in the tissue volume such that the excited fluorescence agent emits fluorescent light, acquiring fluorescence data based on the fluorescent light emitted during blood flow through the tissue volume, estimating a molar concentration of the fluorescence agent in the blood flowing through the tissue volume, and generating an assessment of blood flow in the tissue volume based at least in part on the fluorescence data and the estimated molar concentration of the fluorescence agent. The estimated molar concentration may be based on the predetermined amount of the fluorescence agent and an estimated circulating blood volume of the subject.

公开(公告)号：US20190204402A1

公开(公告)日：2019-07-04

申请号：US16331732

申请日：2017-09-13

Applicant: INSERM (INSTITUT NATIONAL DE LA SANTE DE LA RECHERCHE MEDICALE) ,  UNIVERSITE PARIS DIDEROT - PARIS 7 ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS

Inventor： Benjamin LEPORQ ,  Jean-Luc DAIRE ,  Bernard VAN BEERS

IPC: G01R33/563 ,  A61B5/055 ,  G01R33/56 ,  A61B5/026 ,  A61B5/0275 ,  A61B5/00

CPC classification number: G01R33/56366 ,  A61B5/0263 ,  A61B5/0275 ,  A61B5/055 ,  A61B5/113 ,  A61B5/4244 ,  A61B5/7207 ,  A61B5/7289 ,  A61B2576/02 ,  G01R33/5601 ,  G01R33/5635 ,  G06T7/0016 ,  G06T2207/30056 ,  G06T2207/30104 ,  G16H30/40

Abstract: The invention relates to liver diseases. Liver diseases notably encompass chronic liver disease and liver cancer (a liver primitive cancer or metastasis). There is therefore a need to be able to extract biomarkers for subjects to suffer from this disease. As a consequence, the inventors worked on a method for post-processing images of a region of interest to obtain at least one perfusion parameter and at least one transport parameter. Such method enables to obtain a method which can be implemented on computer and provides access to relevant parameters for liver diseases in an easier and more accurate way. This method may be applied for predicting that a subject is at risk of suffering from such disease, diagnosing a disease, identifying a therapeutic or a biomarker and screening compounds useful as a medicine.

公开(公告)号：US20180220907A1

公开(公告)日：2018-08-09

申请号：US15947221

申请日：2018-04-06

Applicant: Novadaq Technologies ULC

Inventor： Peter DVORSKY ,  David Mark Henri GOYETTE ,  T. Bruce FERGUSON, JR. ,  Cheng CHEN

IPC: A61B5/0275 ,  G06T7/00 ,  G06T7/246 ,  G06T7/90 ,  A61B5/00 ,  A61B6/00 ,  A61B5/026 ,  A61M5/00 ,  G06T7/12

CPC classification number: A61B5/0275 ,  A61B5/0059 ,  A61B5/0261 ,  A61B5/489 ,  A61B5/7225 ,  A61B6/503 ,  A61B6/504 ,  A61B6/507 ,  A61B2576/02 ,  A61M5/007 ,  G06T7/0012 ,  G06T7/12 ,  G06T7/248 ,  G06T7/90 ,  G06T2207/10064 ,  G06T2207/30104

Abstract: Vessel perfusion and myocardial blush are determined by analyzing fluorescence signals obtained in a static region-of-interest (ROI) in a collection of fluorescence images of myocardial tissue. The blush value is determined from the total intensity of the intensity values of image elements located within the smallest contiguous range of image intensity values containing a predefined fraction of a total measured image intensity of all image elements within the ROI. Vessel (arterial) peak intensity is determined from image elements located within the ROI that have the smallest contiguous range of highest measured image intensity values and contain a predefined fraction of a total measured image intensity of all image elements within the ROI. Cardiac function can be established by comparing the time differential between the time of peak intensity in a blood vessel and that in a region of neighboring myocardial tissue both pre and post procedure.

公开(公告)号：US20180071452A1

公开(公告)日：2018-03-15

申请号：US15690472

申请日：2017-08-30

Applicant: Siemens Healthcare GmbH

Inventor： Puneet Sharma ,  Lucian Mihai Itu

IPC: A61M5/00 ,  A61B5/026 ,  A61B6/00 ,  A61B8/08 ,  A61B5/00 ,  A61B8/00

CPC classification number: A61M5/007 ,  A61B5/0035 ,  A61B5/0077 ,  A61B5/0263 ,  A61B5/0275 ,  A61B5/7267 ,  A61B5/7285 ,  A61B5/748 ,  A61B6/469 ,  A61B6/481 ,  A61B6/507 ,  A61B6/541 ,  A61B6/545 ,  A61B8/469 ,  A61B8/481 ,  A61B8/543 ,  A61B2560/029 ,  A61B2576/02 ,  A61M2205/50 ,  A61M2230/04 ,  G16H30/40 ,  G16H40/60 ,  G16H50/50

Abstract: Systems and methods are provided for imaging a patient. Target imaging parameters for imaging a region of interest of a patient are determined based on desired attributes of images to be generated for the region of interest. Administration parameters for administering a contrast agent are determined based on the target imaging parameters using a computational model of blood flow and contrast agent circulation. A trigger time for imaging the region of interest is determined based on the administration parameters using the computational model of blood flow and contrast agent circulation. The region of interest of the patient is caused to be imaged based on the administration parameters and the trigger time.

公开(公告)号：US20170147778A1

公开(公告)日：2017-05-25

申请号：US14947004

申请日：2015-11-20

Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION

Inventor： Darcy Beurle ,  Colin Compas ,  Stephen Moore ,  Christine Schieber ,  Sergiy Zhuk

IPC: G06F19/00 ,  G06F17/50 ,  G06F17/11 ,  A61B5/0275 ,  A61B6/00

CPC classification number: A61B6/563 ,  A61B5/02007 ,  A61B5/0275 ,  A61B6/467 ,  A61B6/481 ,  A61B6/504 ,  A61B6/5211 ,  G16H50/50

Abstract: A system for estimating fractional flow reserve (FFR) includes a front end application to receive image frames from an imaging system to develop a model of a vasculature system based on an observed concentration time profile at locations within the model using contrast dye in the vasculature system and movement of the vasculature system. A graphics processing unit is configured to represent a computed concentration time profile in the vasculature system using a Lattice-Boltzmann Method (LBM) to generate a representation of the vasculature system. A dynamic controller tunes a velocity field based on a mismatch between the observed concentration time profile and the computed concentration time profile at the locations within the model to obtain a best estimate of the velocity field to perform a FFR measurement.

公开(公告)号：US20170084024A1

公开(公告)日：2017-03-23

申请号：US15224088

申请日：2016-07-29

Applicant: Novadaq Technologies Inc.

Inventor： Lina GUREVICH

IPC: G06T7/00

CPC classification number: A61B5/0071 ,  A61B5/0261 ,  A61B5/0275 ,  A61B5/445 ,  A61B2576/02

Abstract: Methods and systems for assessing tissue of a subject include receiving a time series of signal intensity data capturing the transit of an imaging agent through tissue over a period of time, wherein the tissue comprises a plurality of calculation regions and wherein signal intensity in each calculation region over the period of time may be approximated by a time-intensity curve corresponding to the calculation region; determining, for each calculation region, a coefficient value that is related to at least a portion of the time-intensity curve corresponding to the calculation region; and converting the coefficient values across the plurality of calculation regions into a coefficient-derived image map.