公开(公告)号：US20140161785A1

公开(公告)日：2014-06-12

申请号：US14098797

申请日：2013-12-06

Applicant: Feiyan Liu ,  Ping Wu ,  Kebin Liu

Inventor： Feiyan Liu ,  Ping Wu ,  Kebin Liu

IPC: A61K31/548 ,  C12N9/99 ,  A61K45/06

CPC classification number: A61K31/548 ,  A61K45/06 ,  C12N9/1007 ,  C12Y201/01043 ,  A61K2300/00

Abstract: Verticillin A is found to be a potent inhibitor of histone methyltransferases, selective for G9a, GLP, SUV39H1, SUV39H2, MLL1, and NSD2. Methods of using Verticillin A are provided. The Verticillin A can be synthetically produced or it can be isolated from natural sources. Methods if inhibiting one or more histone methyltransferases are provided. In addition, methods are provided for treating diseases or disorders related to overexpression of one or more histone methyltransferases. Exemplary diseases and disorders to be treated include cancer, asthma, HIV, and progeria.

Abstract translation: 发现秋水仙素A是对G9a，GLP，SUV39H1，SUV39H2，MLL1和NSD2有选择性的组蛋白甲基转移酶的有效抑制剂。 提供了使用秋水仙素A的方法。 秋水仙素A可以合成生产，也可以从天然来源分离。 抑制一种或多种组蛋白甲基转移酶的方法。 此外，提供了用于治疗与一种或多种组蛋白甲基转移酶的过表达相关的疾病或病症的方法。 待治疗的示例性疾病和病症包括癌症，哮喘，HIV和progeria。

公开(公告)号：US07680884B2

公开(公告)日：2010-03-16

申请号：US10502543

申请日：2002-08-28

Applicant: Peng Zhou ,  Yue Liu ,  Kai Zhong ,  Guangxian Yang ,  Kebin Liu ,  Kuncheng Peng

Inventor： Peng Zhou ,  Yue Liu ,  Kai Zhong ,  Guangxian Yang ,  Kebin Liu ,  Kuncheng Peng

IPC: G06F15/16

CPC classification number: H04L41/0893 ,  H04L12/185 ,  H04L63/08 ,  H04L63/0892 ,  H04L63/101

Abstract: A system and method for implementing controlled multicast, wherein comprises Ethernet switch 1, multicast router 2, as well as portal server 3 and AAA server 4 that connect with the multicast router, where Ethernet switch 1 connects with each hosts of user in a downlink, in an uplink connects with multicast router 5 and implements multicast switch of layer 2; portal server 3 is used as an interface for access authentication of the user, AAA server 4 is used to store configuration of user privilege for joining in a multicast group; multicast router 2 connects with multicast router 5 of other systems in the uplink, and cooperates together with AAA server 4 to completes privilege authentication for the user when he joins in the multicast group, distributes a control command according to results of the authentication, and controls forwarding of the multicast made by Ethernet switch 1. The method according to the present invention can resolve better the authenticated authorization and controlled problem of the sender and receiver joining in the multicast, and can identify the host joining in or leaving the multicast group expediently, actively stop the user's group member identification through offline without any influence on the forwarding efficiency.

Abstract translation: 一种用于实现受控组播的系统和方法，包括以太网交换机1，组播路由器2以及与组播路由器连接的门户服务器3和AAA服务器4，其中以太网交换机1在下行链路中与用户的每个主机连接， 在上行链路上与组播路由器5连接，实现层2的组播切换; 门户网站服务器3用作用户接入认证的接口，AAA服务器4用于存储加入组播组的用户权限配置; 组播路由器2与上行其他系统的组播路由器5连接，与AAA服务器4配合，在用户加入组播组时，对用户进行特权认证，根据认证结果分配控制命令，控制 转发由以太网交换机1发起的组播。根据本发明的方法可以更好地解决发送方和接收方加入多播的认证授权和受控问题，并且可以方便地识别加入或离开组播组的主机， 通过离线主动停止用户组成员身份识别，不影响转发效率。

公开(公告)号：US20120219568A1

公开(公告)日：2012-08-30

申请号：US13404503

申请日：2012-02-24

Applicant: Feiyan Liu ,  Kebin Liu ,  Ping Wu

Inventor： Feiyan Liu ,  Kebin Liu ,  Ping Wu

IPC: A61K39/395 ,  A61P35/00 ,  C12N5/09 ,  A61K31/548 ,  C07D513/22 ,  A61K38/19

CPC classification number: A61K31/549 ,  A61K31/282 ,  A61K31/513 ,  A61K31/704 ,  A61K31/7048 ,  A61K33/24 ,  A61K2300/00

Abstract: Compositions containing epidithiodioxopiprazines and methods of their use are provided. Epidithiodioxopiprazines can be isolated from natural resources or synthesized de novo. Moreover, epidithiodioxopiprazines, including Verticillin A, are shown to effectively sensitize multiple types of tumor cells to TRAIL-induced apoptosis. In addition, epidithiodioxopiprazines, including Verticillin A, are shown to effectively overcome cancer cell resistance to existing drugs (i.e. Etoposide, Cisplatin, 5-FU and Doxorubicin). Therefore, compositions and methods are provided for use in sensitizing target cancer cells to death receptor- and other anticancer drugs-induced apoptosis. Methods of treating cancer in a subject in need thereof are also provided.

Abstract translation: 提供了含有二硫代哌嗪的组合物及其使用方法。 可以从天然资源中分离出来，从而重新合成二硫代哌嗪。 此外，包括秋水仙素A在内的外周碘碘草啶显示有效地使多种类型的肿瘤细胞对TRAIL诱导的细胞凋亡敏感。 另外，包括露青霉素A在内的周围二氧代哌嗪有效地克服了癌细胞对现有药物（即依托泊苷，顺铂，5-FU和多柔比星）的耐药性。 因此，提供组合物和方法用于使靶癌细胞对死亡受体和其他抗癌药物诱导的细胞凋亡敏感。 还提供了在有需要的受试者中治疗癌症的方法。

公开(公告)号：US20050091313A1

公开(公告)日：2005-04-28

申请号：US10502543

申请日：2002-08-28

Applicant: Peng Zhou ,  Yue Liu ,  Kai Zhong ,  Guangxian Yang ,  Kebin Liu ,  Kuncheng Peng

Inventor： Peng Zhou ,  Yue Liu ,  Kai Zhong ,  Guangxian Yang ,  Kebin Liu ,  Kuncheng Peng

IPC: H04L12/70 ,  H04L12/18 ,  H04L12/24 ,  H04L12/44 ,  H04L12/66 ,  H04L12/723 ,  H04L29/06 ,  G06F15/16

CPC classification number: H04L41/0893 ,  H04L12/185 ,  H04L63/08 ,  H04L63/0892 ,  H04L63/101

Abstract: A system and method for implementing controlled multicast, wherein comprises Ethernet switch 1, multicast router 2, as well as portal server 3 and AAA server 4 that connect with the multicast router, where Ethernet switch 1 connects with each hosts of user in a downlink, in an uplink connects with multicast router 5 and implements multicast switch of layer 2; portal server 3 is used as an interface for access authentication of the user, AAA server 4 is used to store configuration of user privilege for joining in a multicast group; multicast router 2 connects with multicast router 5 of other systems in the uplink, and cooperates together with AAA server 4 to completes privilege authentication for the user when he joins in the multicast group, distributes a control command according to results of the authentication, and controls forwarding of the multicast made by Ethernet switch 1. The method according to the present invention can resolve better the authenticated authorization and controlled problem of the sender and receiver joining in the multicast, and can identify the host joining in or leaving the multicast group expediently, actively stop the user's group member identification through offline without any influence on the forwarding efficiency.

Abstract translation: 一种用于实现受控组播的系统和方法，包括以太网交换机1，组播路由器2以及与组播路由器连接的门户服务器3和AAA服务器4，其中以太网交换机1在下行链路中与用户的每个主机连接， 在上行链路上与组播路由器5连接，实现层2的组播切换; 门户网站服务器3用作用户接入认证的接口，AAA服务器4用于存储加入组播组的用户权限配置; 组播路由器2与上行其他系统的组播路由器5连接，并与AAA服务器4配合，在用户加入组播组时完成用户的特权认证，根据认证结果分配控制命令，控制 以太网交换机1转发组播。 根据本发明的方法可以更好地解决发送方和接收方加入多播的认证授权和受控问题，并且可以方便地识别加入或离开组播组的主机，通过离线主动停止用户组成员身份识别，而不用 对转发效率的影响。