利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

5 条记录 (耗时 0.01 秒)

    Sulfoxide compounds and acetone complexes, and a process for producing the same
    1.
    发明授权
    Sulfoxide compounds and acetone complexes, and a process for producing the same 有权
    亚砜化合物和丙酮络合物及其制备方法

    公开(公告)号：US06180652B2

    公开(公告)日：2001-01-30

    申请号：US09433786

    申请日：1999-11-03

    申请人： Masahiko Tsujii ,  Nobuo Niikawa ,  Keizo Takayanagi ,  Shigeharu Nochi

    发明人： Masahiko Tsujii ,  Nobuo Niikawa ,  Keizo Takayanagi ,  Shigeharu Nochi

    IPC分类号： A61K3144

    CPC分类号： C07D401/12

    摘要： The present invention provides acetone complexes of sulfoxide compounds, useful as medicines such as inhibitors of gastric acid secretion and anti-ulcer agents or as intermediates for production of medicines, a process for producing the same and a purification method of using the same. Namely, it is the acetone complexes of sulfoxide compounds or of pharmaceutically acceptable salts thereof represented by the following formula: (wherein R1 represents a hydrogen atom, a methoxy group or a difluoromethoxy group, R2 represents a methyl group or a methoxy group, R3 represents a 3-methoxypropoxy group, a methoxy group or a 2,2,2-trifluoroethoxy group, R4 represents a hydrogen atom or a methyl group, n and m independently represent an integer of 1 to 4, and B represents a hydrogen atom, an alkali metal atom or ½ alkaline earth metal atom), which are obtained by treating the sulfoxide compounds or pharmaceutically acceptable salts thereof with acetone.

    摘要翻译： 本发明提供了可用作胃酸分泌抑制剂和抗溃疡剂等药物的亚砜化合物的丙酮配合物，或作为制造药物的中间体的方法及其使用方法。名义上， 它是由下式表示的亚砜化合物或其药学上可接受的盐的丙酮络合物：其中R1表示氢原子，甲氧基或二氟甲氧基，R2表示甲基或甲氧基，R3表示3 - 甲氧基丙氧基，甲氧基或2,2,2-三氟乙氧基，R4表示氢原子或甲基，n和m独立地表示1〜4的整数，B表示氢原子，碱金属 原子或½碱土金属原子），其通过用丙酮处理亚砜化合物或其药学上可接受的盐而获得。

    Sulfoxide compounds and acetone complexes, and a process for producing the same
    3.
    发明授权
    Sulfoxide compounds and acetone complexes, and a process for producing the same 有权
    亚砜化合物和丙酮络合物及其制备方法

    公开(公告)号：US06545024B1

    公开(公告)日：2003-04-08

    申请号：US09688810

    申请日：2000-10-17

    申请人： Masahiko Tsujii ,  Nobuo Niikawa ,  Keizo Takayanagi ,  Shigeharu Nochi

    发明人： Masahiko Tsujii ,  Nobuo Niikawa ,  Keizo Takayanagi ,  Shigeharu Nochi

    IPC分类号： A61K3144

    CPC分类号： C07D401/12

    摘要： The present invention provides acetone complexes of sulfoxide compounds, useful as medicines such as inhibitors of gastric acid secretion and anti-ulcer agents or as intermediates for production of medicines, a process for producing the same and a purification method of using the same. Namely, it is the acetone complexes of sulfoxide compounds or of pharmaceutically acceptable salts thereof represented by the following formula: (wherein R1 represents a hydrogen atom, a methoxy group or a difluoromethoxy group, R2 represents a methyl group or a methoxy group, R3 represents a 3-methoxypropoxy group, a methoxy group or a 2,2,2-trifluoroethoxy group, R4represents a hydrogen atom or a methyl group, n and m independently represent an integer of 1 to 4, and B represents a hydrogen atom, an alkali metal atom or ½ alkaline earth metal atom), which are obtained by treating the sulfoxide compounds or pharmaceutically acceptable salts thereof with acetone.

    摘要翻译： 本发明提供了可用作胃酸分泌抑制剂和抗溃疡剂等药物的亚砜化合物的丙酮配合物，或作为制造药物的中间体的方法及其使用方法。名义上， 它是由下式表示的亚砜化合物或其药学上可接受的盐的丙酮络合物：其中R1表示氢原子，甲氧基或二氟甲氧基，R2表示甲基或甲氧基，R3表示3 甲氧基丙氧基，甲氧基或2,2,2-三氟乙氧基，R 4表示氢原子或甲基，n和m分别表示1〜4的整数，B表示氢原子，碱金属原子 或1/2碱土金属原子），其通过用丙酮处理亚砜化合物或其药学上可接受的盐而获得。

    4-cyanopiperidine derivatives
    5.
    发明授权
    4-cyanopiperidine derivatives 失效
    4-氰基哌啶衍生物

    公开(公告)号：US4721788A

    公开(公告)日：1988-01-26

    申请号：US883697

    申请日：1986-07-08

    申请人： Hiroshi Yamauchi ,  Seiichiro Nomoto ,  Isao Sugiyama ,  Yuuki Komatu ,  Takeo Kanai ,  Keizo Takayanagi ,  Yasuhide Tanaka ,  Atsushi Koiwa ,  Shinichi Endoh

    发明人： Hiroshi Yamauchi ,  Seiichiro Nomoto ,  Isao Sugiyama ,  Yuuki Komatu ,  Takeo Kanai ,  Keizo Takayanagi ,  Yasuhide Tanaka ,  Atsushi Koiwa ,  Shinichi Endoh

    IPC分类号： C07D211/62 ,  C07D453/02 ,  C07D211/26

    CPC分类号： C07D453/02 ,  C07D211/62

    摘要： A novel 4-cyanopiperidine derivative, which is represented by the following general formula (I): ##STR1## wherein X means a halogen atom, or an acid addition salt thereof, is prepared by reacting N-(2-hydroxyethyl)-4-carbamoylpiperidine or an acid addition salt thereof with a dehydrating and halogenating agent; or by reacting 4-cyanopiperidine or a salt thereof with a compound represented by the following general formula (IV):X--CH.sub.2 CH.sub.2 --Y (IV)wherein X has the same meaning as defined above and Y denotes the same halogen atom as X or another halogen atom. The derivative is useful as intermediate for synthesis of quinuclidine derivative which is in turn useful as intermediate for the production of medicines, chemicals, etc.

    摘要翻译： 由下列通式（I）表示的新颖的4-氰基哌啶衍生物：其中X表示卤素原子或其酸加成盐的方法是通过使N-（2-羟基乙基） -4-氨基甲酰基哌啶或其酸加成盐与脱水和卤化剂反应; 或通过使4-氰基哌啶或其盐与下述通式（IV）表示的化合物反应：X-CH 2 CH 2 -Y（IV）其中X具有与上述相同的含义，Y表示与X相同的卤素原子或 另一个卤素原子。 该衍生物可用作合成奎宁环衍生物的中间体，其可用作药物，化学品等的生产中间体。